Duffy blood group genotypes among malaria Plasmodium vivax patients of Baoulch population in southeastern Iran

作     者：Ebrahim Miri-Moghaddam Zakaria Bameri Mehdi Mohamadi 

作者机构：Genetics of Non-Communicable Disease Research CentreZahedan University of Medical Sciences Department of GeneticsZahedan University of Medical Sciences Infections and Tropical Research CenterZahedan University of Medical Sciences Health Promotion Research CenterZahedan University of Medical Sciences 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2014年第7卷第3期

页      面：202-206页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

主　　题：Malaria Vivax Duffy Blood group Genotype Allele Balouch Iran Plasmodium vivax 

摘      要：Objective:To determine the distribution of Duffy blood group genotypes in Balouch population as a major ethnic group that living in a sub-tropical area in south East of ***:In this study,the Duffy blood group FY phenolypes were determined using indireet anti-globulin technique and also genotype by PCR-RFLP in 160 vivax malaria patients and 160 control ***:The results showed that the most common Duffy geitolype was FYA/FYB(46.6%)followed by FYA/FYA(15.3%),FYA/FYO(14.4%),FYB/FYO(11.9%,),FYB/FYB(10%)and FYO/FYO(1.9%).In case individuals,frequency of FY *** and FYO alleles were 0.471,0.431and 0.097,respectively compaired to 0.444,0.353 and 0.203,respectively in control(non-infected)***:This data provide evidence that individuals with the FYA/FYB genotype have higher susceptibility to malaria and there are significant associations between Duffy blood group variants and susceptibility or resistance to vivax malaria.