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vivax malaria:a rare cause of thalamic bleed

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 665-666页

作者： Jaydeep Sarkar Biku Naik Atul Gawande Atul Goel Department of Internal Medicine Lady Hardinge Medical CollegePGIMERand Dr.RML HospitalNew DelhiIndia

Most common cause of thalamic bleed is hypertension;other causes are arteriovenous malformation,aneurysm,bleeding thathesis,drugs,amyloid angiopathy,tumor *** present a case of Plasmodium vivax(***) malaria with unusual site of bleeding *** thalamus of *** the best of our knowledge,this is the first reported case of thalamic bleed caused by vivax malaria in absence of severe thrombocytopenia/disseminated intravascular coagulation (DIC).

关键词： Malaria Plasmodium vivax Bleed Thalamus Rapid malaria test

The genetic polymorphism of Plasmodium vivax genes in endemic regions of Thailand

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Asian Pacific Journal of Tropical Medicine 2011年第12期4卷 931-936页

作者： Varakorn Kosaisavee Ian Hastings Alister Craig Usa Lek-Uthai Department of Parasitology and Entomology Faculty of Public HealthMahidol UniversityBangkokThailand Faculty of Graduate Studies Mahidol University.NakornpathomThailand Department of Molecular and Biochemical Parasitology.Liverpool School of Tropical Medicine Pembroke PlaceLiverpoolUK

Objective:To investigate the genetic polymorphism of Plasmodium vivax(***) PvCSP and PvMSP1 genes from field isolates at four endemic regions(North,East,West and South) of ***:The 152 *** injected cases from dried blood spots were DMA extracted and confirmed by species-specific primer sets using multiplex PCR *** fragments F2 and F3:PvCSP were gcnotvped using RFLP-PCR ***:Totally amplified DNA which was multiple genotypes for PvMSP1 F2 and PvMSP1 F3 were 12.50%and 8.55%.respectively while PvCSP was 3.95%.The overall frequency of multiple genotypes was 25%.There were 12 allele tvpes of PvMSP1 F2 using AluI enzyme digestion and 8 size variations were found in P\MSP1 *** isolates from western region was highly genetic diverse when compare among all *** predominant variant type of PvCSP gene was \ K2I0 ***:The niulliple genotypes are common found in Thailand and it might hide the real *** does not have extensive genetic diversity in this *** marker due to multiple genotypes is difficult In be *** multiple genotypes findings might stem from population migration and vector species findings.

关键词： Genetic polymorphism Plasmodium vivax PvMSP1 PvCSP

Higher-Dose Primaquine to Prevent Relapse of Plasmodium vivax Malaria

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四川生理科学杂志 2022年第2期44卷 347-347页

作者： Nathália N Chamma-Siqueira From Instituto Evandro Chagas Ministério da Saúde do Brasil Ananindeua (N.N.C-.S. S.P.S. G.M.R.V.) Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários (N.N.C.-S. E.J.M.S. F.P.C. G.M.R.V.) and Laboratório de Genética de Doenças Complexas (E.J.M.S. F.P.C.) Instituto de Ciências Biológicas and Laboratório de Farmacocinética de Drogas Antimaláricas Instituto de Ciências da Saúde (L.W.P.S. A.G.N.C.-M.) Universidade Federal do Pará Belém Secretaria de Saúde do Estado do Acre Cruzeiro do Sul (S.C.N. S.F.) and Grupo Técnico da Malária Coordenação-Geral de Vigilância de Zoonoses e Doenças de Transmissão Vetorial Departamento de Imunização e Doenças Transmissíveis Secretaria de Vigilância em Saúde Ministério da Saúde (P.B.M.) and Diretoria de Vigilância Epidemiológica Subsecretaria de Vigilância em Saúde Secretaria Estadual de Saúde do Distrito Federal (C.R.L.P.) Brasília - all in Brazil Epidemic Intelligence Service Center for Surveillance Epidemiology and Laboratory Services (S.-B.B.) and the Malaria Branch Division of Parasitic Diseases and Malaria Center for Global Health Centers for Disease Control and Prevention (S.-B.B. A.M.O.) - both in Atlanta and Instituto de Investigaciones en Ciencias Biomedicas Universidad Ricardo Palma Lima and Instituto de Enfermedades Tropicales Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas Chachapoyas (S.M.C.) - both in Peru.

Background:In most of the Americas,the recommended treatment to prevent relapse of Plasmodium vivax malaria is primaquine at a total dose of 3.5 mg per kilogram of body weight,despite evidence of only moderate ***:In this trial conducted in Brazil,we evaluated three primaquine regimens to prevent relapse of *** malaria in children at least 5 years of age and in adults with microscopy-confirmed *** *** the patients received directly observed chloroquine for 3 days(total dose,25 mg per kilogram).Group 1 received a total primaquine dose of 3.5 mg per kilogram(0.5 mg per kilogram per day)over 7 days with unobserved administration;group 2 received the same regimen as group 1 but with observed administration;and group 3 received a total primaquine dose of 7.0 mg per kilogram over 14 days(also 0.5 mg per kilogram per day)with observed *** monitored the patients for 168 days.

关键词： vivax Malaria regimen

Multiple splenic infarcts in acute Plasmodium vivax malaria:A rare case report

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Asian Pacific Journal of Tropical Medicine 2013年第5期6卷 416-418页

作者： Hari Krishan Aggarwal Deepak Jain Vipin Kaverappa Promil Jain Ashwani Kumar Sachin Yadav Department of Medicine Pt.B.D.Sharma University of Health SciencesRohtak-124001HaryanaIndia Department of Pathology Pt.B.D.Sharma University of Health SciencesRohtak-124001HaryanaIndia

In tropical countries like India,malaria has been one of the most common parasitic illnesses leading to frequent hospitalization and causing major economic burden among the masses. Although Plasmodium vivax infection is considered to be benign,in contrast to Plasmodium, falciparum infection which is notorious for its severe splenic complications can occur frequently. Splenomegaly tends not to receive special attention,as it is not usually accompanied by any symptoms and can be gradually resolved via standard antimalarial *** infarction, although rarely attributable to malaria in an endemic region with high parasitemia,can be a rare presentation of this disease entity.

关键词： Malaria Splenic infarcts Plasmodium vivax

Conserved regions of Plasmodium vivax potential vaccine candidate antigens in Sri Lanka:Conscious in silico analysis of prospective conformational epitope regions

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Asian Pacific Journal of Tropical Medicine 2014年第10期7卷 832-840页

作者： Shanika Amarasinghe Hashendra Kathriarachchi Preethi Udagama Department of Plant Sciences Faculty of ScienceUniversity of ColomboCumarathungaMunidasaMawatha Department of Zoology Faculty of ScienceUniversity of ColomboCumarathungaMunidasaMawatha

Objective:To do mapping and modeling of conformational B cell epitope regions of highly conserved and protective regions of three merozoitecandidate vaccine proteins of Plasmodium vivax(***),*** purface protein-1(PvMSP-1),apical membrane antigen-1 domainⅡ(PvAMA1-DⅡ)and regionⅡof the Duffy binding protein(PvDBPⅡ).and to analyze the immunogenie properties of these predicted ***:3-D structures of amino acid haplotypes from Sri Lanka(available in GeneBank)of PvMSP-1_(19)(n=27),PvAMA1-DⅡ(n=21)and PvDBPⅡ(n=33)were ***,selected as the best online server was used for conformational epitope predictions,while prediction and moodeling of protein structuve and properties related to immunogenicity was carried out with Geno3D *** Protein Server,NetSurfP Server and standaloneroftware,Genious ***:SEPPA revealed that regions of predicted conformational epitopes formed 4 clusters in PvMSP-I_(19),and 3 clusters each in PvAMA1-DⅡand PvDBPⅡ,all of which displayed a high degree of hydrophilicity,contained solveut exposed residues,displayed high probability of antigenicity and showed positive antigenic propensity values,that indicated high degree of ***:Findings of this study revealed and confirmed that different parts of the sequences of each of the conserved regions of the three selected potential vaccine candidate antigens of *** are important with regard to conformational epitope prediction that warrants further laboratory experimental invertigations in in vivo animal models.

关键词： Plasmodium vivax PvMSP-119 PvAMA1-DⅡ PvDBPⅡ Conserved regions Conformational epitopes Immunogenicity

A study on the clinical profile of complicated Plasmodium vivax mono-infections

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Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 560-562页

作者： Peter George Lobo Manuel Alexander Department of Medicine Yenepoya Medical CollegeUniversity RoadDeralakateMangaloreKamataka StateS India 575018 Department of Medicine Fr Muller Medical CollegeFr Muller RoadMangaloreKarnataka StateS India 575002

Objective:To identify cases of severe Plasmodium vivax(***) mono-infections among ***:In this retrospective study,30 adult patients admitted to medical wards of a tertiary hospital in a malaria endemic urban area from March 2010 to April 2010 were included. The diagnosis of *** malaria was established by peripheral blood film(PBF) examination, and severe malaria was categorized as per World Health Organization ***: Complications observed were thrombocytopenia in 28(93.3%),hepatic dysfunction and jaundice in 13(433%),renal dysfunction in 8(26.7%),severe anaemia in 3(10.0%),cerebral malaria in 2 (6.7%),and acute respiratory distress syndrome(ARDS) in 1(3.3%) of 30 ***:P. vivax malaria with severe complications is common in the investigated area,and an intensive and large-scale study of the disease is necessary.

关键词： Plasmodium vivax malaria Mono-infection Complication

Spectrum of complications associated with Plasmodium vivax infection in a tertiary hospital in South-Western India

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Asian Pacific Journal of Tropical Medicine 2012年第1期5卷 79-82页

作者： Kushal Naha Sowjanya Dasari Mukhyaprana Prabhu Department of Medicine Kasturba HospitalManipal-576 104KarnatakaIndia

Objective:To determine the range and incidence of complications associated with Plasmodium vivax[***) ***:A retrospective analysis was performed of all patients of *** malaria admitted in kasturba Medical *** between January and December,*** with mixed malarial infection were excluded by appropriate tests. Clinical presentation and laboratory parameters were ***:Medical records of 213 individuals who satisfied the inclusion criteria were *** was seen in 65 (30.5%),leucopenia in 38(17.8%]and thrombocytopenia in 184(86.4%l *** and alanine aminotransferases were elevated in 86(40.4%).and 89(41.9%) patients respectively. Hypoalbuminemia was observed in 157(73.6%) *** serum creatinine was noted in in 59(27.5%) *** kinase was elevated in 30 nut of 59 patients(50.8%).Overall.107 (50.2%) patients fulfilled WHO criteria for sever=e *** of the patients succumbed to the ***:*** malaria is a potentially severe disease,and the term ’ benign" tertian malaria is a *** significant morbidity,with timely and appropriate treatment *** malaria has an excellent outcome.

关键词： Plasmodium vivax malaria Complications Benign tertian malaria

Plasmodium vivax cerebral malaria complicated with venous sinus thrombosis in Colombia

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Asian Pacific Journal of Tropical Medicine 2013年第5期6卷 413-415页

作者： Miguel A Pinzon Juan C Pineda Fernando Rosso Masaru Shinchi Fabio Bonilla-Abadia Department of Infectious Diseases Hospital San Vicente de PaulMedellinColombia Department of Internal Medicine Fundacion Clinica Valle del LiliICESI UniversityCaliColombia Department of Infectious Diseases Fundacion Clinica Valle del LiliCaliColombia Department of Neurology Fundacion Clinica Valle del LiliCuliColombia Department of Rheumatology Fundacion Clinica Valle del LiliICESI UniversityCaliColombia

Complicated malaria is usually due to Plasmodium ***,Plasmodium vivax is infrequently related with life-threatening *** cases have been reported of severe Plasmodium vivax infection,and most of them from Southeast Asia and *** report the first case of cerebral malaria due to Plasmodium vivax in Latin America,complicated with sagittal sinus thrombosis and confirmed by a molecular method.

关键词： Cerebral malaria vivax malaria Plasmodium vivax Intracranial sinus thrombosis

Assessment of in vitro sensitivity of Plasmodium vivax fresh isolates

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 49-53页

作者： Poonuch Muhamad Wanna Chacharoenkul Kanchana Rungsihirunrat Ronnatrai Ruengweerayut Kesara NaBangchang Pharmacology and Toxicology Unit Graduate Program in Biomedical SciencesThammasat University College of Public Health Chulalongkorn University Mae-Sot General Hospital

Objective:To compare the applicability of the SYBK Grcen-Ⅰ assay with the standard schizont maturalion assay,for determination of sensitivity of Plasmodium vivax(***) to chloroquine and a new antifolale WR ***:The study was conducted at Mae Tao Clinic for migrant workers,Tak Province during April 2009 to July 2010.A total of 64 blood samples(1 mL blood collected into sodium heparinized plastic tube) were collected from patients with monoinfection with *** malaria prior to treatment with standard regimen of a 3-day chloroquine. In vitro sensitivity of *** isolates was evaluated by schizont maturation inhibition and SYBR Green-Ⅰ ***:A total of 30 out of 64 blood samples collected from patients with *** malaria were successfully analyzed using both the microscopic schizont maturation inhibition and SYBR Green-I *** failure rates of the schizont maturation inhibition assay(50%) and the SYBR Green-I assay(54%) were similar(P=0.51).The median IC_(10)s,IC_(50)s and IC_(90)s of both chloroquine and WR99210 were not significantly different from the clinical isolates of *** *** on the cut-off of 100 nM,the prevalences of chloroquine resistance determined by schizont maturation inhibition and SYBR Green-I assays were 19 and 11 isolates,*** strength of agreement between the two methods was very poor for both chloroquine and ***:On the basis of this condition and its superior sensitivity,the microscopic method appears better than the SYUK Green-I Green assay for assessing in vitro sensitivity of fresh *** isolates to antimalarial drugs.

关键词： Plasmodium vivax Chloroquine In vitro sensitivity Schizont maturation inhibition assay SYBR Green-Ⅰassay Fresh isolate Antifolate Malaria Antimalarial drug Standard regimen