Serum microtubule-associated protein light chain 3 typeⅡlevels correlate with aggravation and multi-organ dysfunction in septic patients

作     者：Wei Huang Da-Wei Liu Guang-Jian Wang Hong-Min Zhang Gao-Sheng Zhou Jing-Jing Liu Xiao-Ting Wang Huang Wei;Liu Da-Wei;Wang Guang-Jian;Zhang Hong-Min;Zhou Gao-Sheng;Liu Jing-Jing;Wang Xiao-Ting

作者机构：Department of Critical Care MedicinePeking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第14期

页      面：1732-1734页

核心收录：

学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：the Chinese National Natural Science Foundation(No.81671878) the Key Project of Central Health Care Scientific Research(No.2020ZD08) 

主　　题：patients protective Serum 

摘      要：Sepsis involves the early activation of both pro-and antiinflammatory responses,but is also accompanied by major changes in nonimmunologic pathways.[1]Autophagy is the lysosome-dependent process of removing damaged proteins and organelles.[2]Accumulating evidence from in vitro and in vivo studies reveals that autophagy may have a protective effect on sepsis,and the late-stage suppression of autophagy is associated with a poor outcome.[3]Thus,reversal of late-stage autophagy may be a good therapeutic strategy for ***,the identification of biomarker,which could inform the clinical diagnosis of autophagic impairment,will be essential for guiding the management of septic patients.