The Comparative Study of Gelatin/CNT-contained Mg-Ca-P Bone Cement with the Plain and CNT-reinforced Ones

作     者：Mohammad Hossein Esnaashary Masoud Karfarma Hamid Reza Rezaie Alireza Khavandi Jafar Javadpour Mohammad Hossein Esnaashary;Masoud Karfarma;Hamid Reza Rezaie;Alireza Khavandi;Jafar Javadpour

作者机构：School of Metallurgical and Materials EngineeringIran University of Science and TechnologyNarmakTehran16844Iran 

出 版 物：《Journal of Bionic Engineering》 (仿生工程学报（英文版）)

年 卷 期：2021年第18卷第3期

页      面：623-636页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

主　　题：magnesium phosphate cement gelatin carbon nanotube bone mimicking cell response bone cement biomaterials 

摘      要：Mimicking compositional and constructional features of the extracellular matrix(ECM)is an effective parameter in improving the biological response of *** this regard,carbon nanotube(CNT)and gelatin were added to magnesium-calcium phosphate cement(CNG)to mimic fibrillar construction and organic composition of ECM,respectively,besides the CNG performance was compared with the plain and CNT-reinforced *** behavior of the cements was investigated by evaluating their setting time,cement composition variation during setting,and viscosity ***,compressive strength,degradation,and cell response of the cements were *** 5 wt.%gelatin reduced setting time about 60%,because of gel formation,not due to struvite ***,the gelatin decreased compressive strength by about 20%.Although gelatin decreased compressive strength,the strength remained in the range attributed to trabecular *** the types of cement indicated shear thinning behavior that made their injectability *** to other types of cement,CNG enhanced proliferation and differentiation of mesenchymal stem cells besides faster degradation,nontoxicity and suitable cell ***,mimicking features of CNG enhanced osteoconductivity and osteoinductivity of the cement compared to the plain one.