An intriguing electrochemical impedance aptasensor based on a porous organic framework supported silver nanoparticles for ultrasensitively detecting theophylline

作     者：Zhang-Ye Han Hong-Kai Li Qian-Qian Zhu Rongrong Yuan Hongming He Zhang-Ye Han;Hong-Kai Li;Qian-Qian Zhu;Rongrong Yuan;Hongming He

作者机构：Tianjin Key Laboratory of Structure and Performance for Functional MoleculesCollege of ChemistryTianjin Normal UniversityTianjin 300387China Department of Materials Science and EngineeringJilin Jianzhu UniversityChangchun 130118China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第9期

页      面：2865-2868页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 081704[工学-应用化学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 070302[理学-分析化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：financially supported by the National Natural Science Foundation of China(No.21801187) 

主　　题：Ag@POF composite Aptamer Electrochemical aptasensor Theophylline Sensitive detection 

摘      要：Porous organic frameworks(POFs)are excellently stable porous materials,which can be employed as host platforms to support metal nanoparticles as functional composites for various ***,a novel POF is successfully prepared via Friedel-Crafts *** nanoparticles(AgNPs)are embedded in the prepared POF to generate an Ag@POF composite,which not only possesses high surface area,outstanding physicochemical stability and outstretchedπ-conjugation skeleton,but also exhibits preferable electrochemical stability and *** composite is able to immobilize a mass of aptamer strands to fabricate an intriguing electrochemical *** impedance spectroscopy(EIS)is a commonly used technology to analyze the electrochemical signal *** Ag@POF-based biosensor shows the excellent electrochemical detection behavior through analyzing *** instance theophylline as a research mode,the Ag@POF based electrochemical aptasensor reveals ultra-sensitiveness,high selectivity,remarkable stability,good repeatability and simple operability even in various real ***,this aptasensor has the sensitive detection performance with the limit of detection of 0.191 pg/m L(1.06 pmol/L)in a wide concentration range of 5.0×10^(-4)–5.0 ng/m L(2.78×10^(-3)–27.8 nmol/L).