Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence

作     者：Yingying Zhang Tiange Wang Yu Tian Chaonan Zhang Kun Ge Jinchao Zhang Jin Chang Hanjie Wang Yingying Zhang;Tiange Wang;Yu Tian;Chaonan Zhang;Kun Ge;Jinchao Zhang;Jin Chang;Hanjie Wang

作者机构：School of Life SciencesTianjin UniversityTianjin 300072China Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment TechnologyTianjin Key Laboratory of Function and Application of Biological Macromolecular StructuresTianjin 300072China College of Chemistry&Environmental ScienceKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationChemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding 071002China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第7期

页      面：1978-1992页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：sponsored by National Key Research and Development Program of China(2017YFA0205104 and 2019YFA0906500) National Natural Science Foundation of China(51873150,31971300 and 817719709) Tianjin Natural Science Foundation(19JCYBJC28800) Young Elite Scientists Sponsorship Program by Tianjin the Key project of Tianjin Foundational Research(Jing Jin Ji)Program,China(19JCZDJC64100) 

主　　题：Synergistic immunotherapy Post-surgical tumor recurrence Theranostics Gold nanorods Phototherapy Lung metastasis Fluorescence resonance energy transfer Carcinoembryonic antigen 

摘      要：Tumor recurrence after surgery is the main cause of treatment ***,the initial stage of recurrence is not easy to detect,and it is difficult to cure in the late *** order to improve the life quality of postoperative patients,an efficient synergistic immunotherapy was developed to achieve early diagnosis and treatment of post-surgical tumor recurrence,*** this paper,two kinds of theranostic agents based on gold nanorods(AuNRs)platform were *** and quantum dots(QDs)in one agent was used for the detection of carcinoembryonic antigen(CEA),using fluorescence resonance energy transfer(FRET)technology to indicate the occurrence of in situ recurrence,while AuNRs in the other agent was used for photothermal therapy(PTT),together with antiPDL1 mediated immunotherapy to alleviate the process of tumor metastasis.A series of assays indicated that this synergistic immunotherapy could induce tumor cell death and the increased generation of CD3;/CD4;T-lymphocytes and CD3+;CD8;***,more immune factors(IL-2,IL-6,and IFN-γ)produced by synergistic immunotherapy were secreted than *** cooperative immunotherapy strategy could be utilized for diagnosis and treatment of postoperative tumor recurrence at the same time,providing a new perspective for basic and clinical research.