A Novel Technique to Validate Dosimetry for Single-Isocenter Multiple-Target VMAT Stereotactic Radiosurgery

作     者：Yulin Song Miao Zhang Laszlo Voros Xiaoli Tang Ziad Saleh Weixing Cai Jeho Jeong Boris Mueller Borys Mychalczak Yulin Song;Miao Zhang;Laszlo Voros;Xiaoli Tang;Ziad Saleh;Weixing Cai;Jeho Jeong;Boris Mueller;Borys Mychalczak

作者机构：Department of Medical Physics Memorial Sloan Kettering Cancer Center New York USA Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York USA 

出 版 物：《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 (医学物理学、临床工程、放射肿瘤学（英文）)

年 卷 期：2021年第10卷第2期

页      面：59-68页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Brain Metastasis VMAT SRS WBRT Film Dosimetry 

摘      要： Each year, 170,000 cancer patients in the United States develop brain metastases. Many of them present with multiple small lesions. Historically, Linac-based stereotactic radiosurgery (SRS) was used to treat single solitary brain metastasis with a diameter of less than 3.0 cm, while whole brain radiation therapy (WBRT) was used to treat multiple brain metastases mainly as palliative therapy. Evidence-based practices reveal that WBRT results in poor treatment outcomes, with high local recurrence rates, decreased cognitive function, and even the onset of dementia. Recently, volumetric modulated arc therapy (VMAT) SRS has been tested as an alternative treatment to WBRT. Owing to its inherent complexity and high risk, it is imperative to perform rigorous testing prior to its clinical implementation. In this paper, we present a novel technique for dosimetry validation of VMAT SRS.