Histopathologic Profile of Miscarriages during First Trimester of Pregnancy in Teaching Hospital of Grand Yoff in Dakar (Senegal)

作     者：Mama Sy Diallo Chérif Mohamed Dial Henriette Poaty Oumar Faye 

作者机构：Histology-Embryology and Cytogenetics Laboratory Faculty of Medicine Cheikh Anta Diop University Dakar Senegal Service of Pathology Teaching Universitary Hospital of Grand Yoff Dakar Senegal Histology-Embryology and Genetics Unit Faculty of Health Sciences of Brazzaville Brazzaville Congo National Research Institute on Health Sciences Brazzaville Congo 

出 版 物：《Open Journal of Pathology》 (病理学期刊（英文）)

年 卷 期：2020年第10卷第1期

页      面：56-65页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：Histopathologic Miscarriage Hydatidiform Mole Ectopic Pregnancy 

摘      要：Background: Mainly for economic reasons, histopathologic analysis is not a systematic practice in medical structures in Senegal, and the utility of this exam is being questioned by many authors. The purpose of this paper is to report the results of this exam, in our medical practice and try to determine if this exam should be systematic of kept only for individualized cases. Material and Methods: It was a retrospective study from January 2010 to December 2018, carried out in the Laboratory of Pathology of the Teaching Hospital of Grand Yoff in Dakar. The data were collected from the register of pathologic examinations of the laboratory. Results: We registered 543 results of histopathologic examination of products of conception from the first trimester abortion. The women mean age was 22.4 years ± 6.2 with extremes of 17 and 46 years. The routine histopathologic assessment of products of first- trimester miscarriages highlighted in our study three pathologies: hydatidiform mole (24.7%), infection (4.6%) and ectopic pregnancy (0.09%). Only 11.7% of cases of Hydatidiform mole (HM) were suspected before the histopathologic assessment. In our sample, molar pregnancy seems to be higher in anembryonic conception with a prevalence of 45%. The prevalence of Complete Hydatidiform Mole (CHM) was higher than the one of Partial Hydatidiform Mole (PHM) (14.8% vs. 9.9% of miscarriages). Indeed, both require follow up to prevent or manage at time the occurrence of choriocarcinoma. Conclusion: The results of the histologic analysis after abortion in the first trimester of pregnancy show that this exam should be practiced systematically in routine in our context because of high prevalence of hydatidiform mole.