Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation
作者机构：State Key Laboratory of AgrobiotechnologyCollege of Biological SciencesChina Agricultural UniversityBeijingChina'2 Fujian Provincial Key Laboratory of Reproductive Health ResearchSchool of MedicineXiamen UniversityXiamenChina'3 Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese MedicineFuzhouChina'4 Department of Obstetrics and GynecologyThe First Affiliated Hospital of Xiamen UniversityXiamenChina'5 Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western ChinaCollege of Life ScienceNingXia UniversityYinchuanChina
出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)
年 卷 期：2021年第13卷第9期
页 面：646-661页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学]
基 金：supported by the National Key R&D Program of China(2017YFC1001402 to H.W 2018YFC1004401 to S.K.) the National Natural Science Foundation of China(81830045 and 82030040 to H.W.,81971388 to S.K.) Institution of Higher Education Projects of Building First-class Discipline Construction in Ningxia Region(NXYLXK2017B05 to G.X.)
主 题：IGF1R IGF1 IGF2 uterine epithelium implantation blastocyst
摘 要：Embryo implantation in both humans and rodents is initiated by the attachment of a blastocyst to the uterine *** blastocyst attachment,the uterine epithelium needs to transform at both the structural and molecular levels first,and then initiate the interaction with *** perturbation during this process will result in implantation failure or long-term adverse pregnancy *** steroid hormones,which function through nuclear receptors,combine with the local molecules produced by the uteri or embryo to facilitate *** insulin-like growth factor(IGF)signaling has been reported to play a vital role during ***,its physiological function during implantation remains *** study revealed that mice with conditional deletion of Igflr gene in uteri suffered from subfertility,mainly due to the disturbed uterine receptivity and abnormal embryo ***,we uncovered that in response to the nidatory estrogen on D4 of pregnancy,the epithelial IGF1R,stimulated by the stromal cell-produced IGF1,facilitated epithelial STAT3 activation to modulate the epithelial ***,embryonic derived IGF2 could activate both the epithelial ERK1/2 and STAT3 signaling through IGF1R,which was critical for the transcription of Cox2 and normal attachment *** brief,our data revealed that epithelial IGF1R was sequentially activated by the uterine stromal IGF1 and embryonic IGF2 to guarantee normal epithelium differentiation during the implantation process.
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