Expressions of β_3 Integrin and Fibronectin in Salpingitis
Expressions of β_3 Integrin and Fibronectin in Salpingitis作者机构：Institute of Reproductive Immunology College of Life Science and Technology Jinan University Guangzhou510632 China Department of Pathophysiology Medical College Jinan University Guangzhou 510632 China
出 版 物：《Journal of Reproduction and Contraception》 (生殖与避孕（英文版）)
年 卷 期：2011年第22卷第4期
页 面：211-216页
学科分类：090603[农学-临床兽医学] 0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0906[农学-兽医学]
主 题：β3 integrin fibronectin salpingitis
摘 要：Objective To investigate the association between β3 integrin-fibronectin signaling and salpingitis. Methods Thirteen chronically inflamed tubal samples were included in the case group, while 29 normal fallopian tube samples were set as the controls. Immunohistochemistry was used to determine the distribution patterns and expressions of β3 integrin and fibronectin in the fallopian tube samples. Results β3 integrin was presented in the ciliated cells within the whole length of the normal fallopian tube, but no staining was detected in the tubal epithelium of salpingitis. A similar distribution pattern offibronectin was revealed between the cases and the controls, with exclusive staining in the tubal mucosal matrix and the basement membranes of the tubal epithelium and mucosal vessels, whereas no staining was detected in the tubal epithelial cells. Fibronectin in the samples of salpingitis showed a remarkably stronger-staining than that of the normal controls （P〈0.01）. Conclusion Salpingitis could reduce β3 integrin expression and raise fibronectin expression in the fallopian tube epithelium, concomitantly changed concentrations of β3 integrin and fibronectin seem to have impacts on the onset of salpingitis.
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