Comparative analyses of aging-related genes in long-lived mammals provide insights into natural longevity

作     者：Zhenpeng Yu Inge Seim Mengxin Yin Ran Tian Di Sun Wenhua Ren Guang Yang Shixia Xu 

作者机构：Jiangsu Key Laboratory for Biodiversity and BiotechnologyCollege of Life SciencesNanjing Normal UniversityNanjing 210023China Integrative Biology LaboratoryCollege of Life SciencesNanjing Normal UniversityNanjing 210023China School of Biology and Environmental ScienceFaculty of Science and EngineeringQueensland University of TechnologyBrisbaneQLDAustralia 

出 版 物：《The Innovation》 (创新（英文）)

年 卷 期：2021年第2卷第2期

页      面：31-39页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by the National Natural Science Foundation of China(NSFC,grant nos.32070409,31772448 to S.X.,31872219 to W.R.) the Key Project of the NSFC(grant nos.32030011,31630071 to G.Y.) National Key Programme of Research and Development of China,Ministry of Science and Technology(grant no.2016YFC0503200 to G.Y.and S.X.) the Priority Academic Program Development of Jiangsu Higher Education Institutions to G.Y.and S.X.,and the Qinglan project of Jiangsu Province to S.X.These funding bodies played no role in study design,data collection,analysis,interpretation of data,and writing the manuscript.We are particularly grateful to Dr.Yan-bo Sun(Yunnan University,Kunming,Yunnan,China)for the suggestion of data analysis.Many thanks are also given to Zepeng Zhang,Simin Chai,Yuan Mu,and Weijian Guo for support and discussions 

主　　题：mammals longevity positive selection IIS pathway immune response cancer resistance 

摘      要：Extreme longevity has evolved multiple times during the evolution of mammals,yet its underlying molecular mechanisms remain largely ***,we compared the evolution of 115 aging-related genes in 11 long-lived species and 25 mammals with non-increased lifespan(control group)in the hopes of better understanding the common molecular mechanisms behind *** identified 16 unique positively selected genes and 23 rapidly evolving genes in long-lived species,which included nine genes involved in regulating lifespan through the insulin/IGF-1 signaling(IIS)pathway and 11 genes highly enriched in immune-response-related pathways,suggesting that the IIS pathway and immune response play a particularly important role in exceptional mammalian ***,11 genes related to cancer progression,including four positively selected genes and seven genes with convergent amino acid changes,were shared by two or more long-lived lineages,indicating that long-lived mammals might have evolved convergent or similar mechanisms of cancer resistance that extended their *** suggestion was further corroborated by our identifi-cation of 12 robust candidates for longevity-related genes closely related to cancer.