Mechanical regulation of bone regeneration during distraction osteogenesis

作     者：Ruisen Fu Yili Feng Youjun Liu Haisheng Yang 

作者机构：Department of Biomedical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijingChina 

出 版 物：《Medicine in Novel Technology and Devices》 (医学中新技术与新装备（英文）)

年 卷 期：2021年第11卷第3期

页      面：85-93页

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：This study was supported by the National Natural Science Foundation of China[grant numbers 11702008,11832003] the Beijing Natural Science Foundation[grant numbers 7202003] the Beijing Municipal Education Commission Research Program[grant numbers KM202010005035] 

主　　题：Bone regeneration Computational modeling Distraction osteogenesis Mechanical loading Tissue differentiation 

摘      要：Distraction osteogenesis(DO)is a mechanobiological process of regenerating bone tissue by tension *** is used clinically to lengthen bones or to treat critical size bone *** DO provides satisfactory results in many cases,the prolonged period of treatment remains a major challenge that needs to be *** attempts have been devoted to accelerating bone regeneration during *** common approach is manipulation of the applied mechanical loading by altering distraction *** this article,we reviewed relevant in vivo animal studies exploring the effects of changing mechanical environments,by varying distraction parameters(e.g.,rate and frequency)or adding compression loading,on bone regeneration in *** further presented how the mechanically-regulated bone regeneration process during DO could be simulated by in silico models incorporating mechano-regulatory tissue differentiation rules.A comprehensive review of those in vivo and in silico studies may not solely provide important references for development of improved DO protocols in clinic,but also promote a deeper understanding of the mechanobiological mechanism of bone regeneration.