Mechanical regulation of bone regeneration during distraction osteogenesis
作者机构:Department of Biomedical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijingChina
出 版 物:《Medicine in Novel Technology and Devices》 (医学中新技术与新装备(英文))
年 卷 期:2021年第11卷第3期
页 面:85-93页
学科分类:08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程(可授工学、理学学位)]
基 金:This study was supported by the National Natural Science Foundation of China[grant numbers 11702008,11832003] the Beijing Natural Science Foundation[grant numbers 7202003] the Beijing Municipal Education Commission Research Program[grant numbers KM202010005035]
主 题:Bone regeneration Computational modeling Distraction osteogenesis Mechanical loading Tissue differentiation
摘 要:Distraction osteogenesis(DO)is a mechanobiological process of regenerating bone tissue by tension *** is used clinically to lengthen bones or to treat critical size bone *** DO provides satisfactory results in many cases,the prolonged period of treatment remains a major challenge that needs to be *** attempts have been devoted to accelerating bone regeneration during *** common approach is manipulation of the applied mechanical loading by altering distraction *** this article,we reviewed relevant in vivo animal studies exploring the effects of changing mechanical environments,by varying distraction parameters(e.g.,rate and frequency)or adding compression loading,on bone regeneration in *** further presented how the mechanically-regulated bone regeneration process during DO could be simulated by in silico models incorporating mechano-regulatory tissue differentiation rules.A comprehensive review of those in vivo and in silico studies may not solely provide important references for development of improved DO protocols in clinic,but also promote a deeper understanding of the mechanobiological mechanism of bone regeneration.