Ultrasmall green-emitting carbon nanodots with 80%photoluminescence quantum yield for lysosome imaging

作     者：Xiaokai Chen Xiaodong Zhang Fu-Gen Wu Xiaokai Chen;Xiaodong Zhang;Fu-Gen Wu

作者机构：State Key Laboratory of BioelectronicsSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第10期

页      面：3048-3052页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 070205[理学-凝聚态物理] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 070302[理学-分析化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(No.21673037) 

主　　题：Carbon dots Carbon-based nanomaterials Lysosomal tracking Cell imaging Fluorescent probes 

摘      要：Carbon-based fluorescent nanomaterials have gained much attention in recent *** this work,greenphotoluminescent carbon nanodots(CNDs;also termed carbon dots,CDs)with amine termination were synthesized via the hydrothermal treatment of amine-containing spermine and rose bengal(RB)*** CNDs have an ultrasmall size of~2.2 nm and present bright photoluminescence with a high quantum yield of~80%which is possibly attributed to the loss of halogen atoms(Cl and I)during the hydrothermal *** from most CNDs which have multicolor fluorescence emission,the asprepared CNDs possess excitation-independent emission property,which can avoid fluorescence overlap with other fluorescent ***,the weakly basic amine-terminated surface endows the CNDs with the acidotropic *** a result,the CNDs can accumulate in the acidic lysosomes after cellular internalization and can serve as a favorable agent for lysosome ***,the CNDs have a negligible impact on the lysosomal morphology even after 48 h incubation and exhibit excellent biocompatibility in the used cell models.