Oligodendroglial GABAergic Signaling:More Than Inhibition!
Oligodendroglial GABAergic 发信号: 多于抑制！作者机构：Molecular PhysiologyCenter for Integrative Physiology and Molecular Medicine(CIPMM)University of Saarland66421 HomburgGermany
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2021年第37卷第7期
页 面：1039-1050页
核心收录：
基 金：The authors’research received support from Deutsche Forschungsgemeinschaft(SFB 894 SPP 1757,FOR2289) EraNet-Neuron BrIE,and the HOMFORexzellent2017 program of the University of Saarland Medical School
主 题：GABA GABAA receptor GABAB receptor OPC Oligodendrocyte lineage
摘 要：GABA is the main inhibitory neurotransmitter in the CNS acting at two distinct types of receptor:ligand-gated ionotropic GABAA receptors and G protein-coupled metabotropic GABAB receptors,thus mediating fast and slow inhibition of excitability at central *** signal transmission has been intensively studied in neurons in contrast to oligodendrocytes and their precursors(OPCs),although the latter express both types of GABA *** studies focusing on interneuron myelination and interneuron-OPC synapses have shed light on the importance of GABA signaling in the oligodendrocyte *** this review,we start with a short summary on GABA itself and neuronal GABAergic ***,we elaborate on the physiological role of GABA receptors within the oligodendrocyte lineage and conclude with a description of these receptors as putative targets in treatments of CNS diseases.
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