Tensile mechanical analysis of anisotropy and velocity dependence of the spinal cord white matter:a biomechanical study

作     者：Norihiro Nishida Itsuo Sakuramoto Yoshihiro Fujii Rudolf Yoga Hutama Fei Jiang Junji Ohgi Yasuaki Imajo Hidenori Suzuki Masahiro Funaba Xian Chen Takashi Sakai Norihiro Nishida;Itsuo Sakuramoto;Yoshihiro Fujii;Rudolf Yoga Hutama;Fei Jiang;Junji Ohgi;Yasuaki Imajo;Hidenori Suzuki;Masahiro Funaba;Xian Chen;Takashi Sakai

作者机构：Department of Orthopedic SurgeryYamaguchi University Graduate School of MedicineMinami-KogushiUbeYamaguchiJapan Department of Mechanical and Electrical EngineeringNational Institute of Technology Tokuyama CollegeGakuendaiShunanYamaguchiJapan Faculty of EngineeringYamaguchi UniversityTokiwadai UbeYamaguchiJapan 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第12期

页      面：2557-2562页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 1010[医学-医学技术（可授医学、理学学位）] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：This work was supported by the Japan Society for the Promotion of Science(KARENHI grant number JP 15K20002) by the Yamaguchi University Hospital(a translational promotion grant) 

主　　题：anisotropy dependence external force mechanistic analysis spinal cord injury straining rate stress velocity dependence white matter 

摘      要：In spinal cord injuries,external forces from various directions occur at various ***,it is important to physically evaluate whether the spinal cord is susceptible to damage and an increase in internal stress for external *** hypothesized that the spinal cord has mechanical features that vary under stress depending on the direction and velocity of ***,it is difficult to perform experiment because the spinal cord is very *** are no reports on the effects of multiple external *** this study,we used bovine spinal cord white matter to test and analyze the anisotropy and velocity dependence of the spinal ***-vertical,tensile-parallel,shear-vertical,and shear-parallel tests were performed on the white matter in the fibrous direction(cranial to caudal).Strain rate in the experiment was 0.1,1,10,and 100/*** calculated the Young’s modulus of the spinal *** of the tensile and shear tests revealed that stress tended to increase when external forces were applied parallel to the direction of axon fibers,such as in tensile-vertical and shear-vertical ***,external forces those tear against the fibrous direction and vertically,such as in tensile-parallel and shear-parallel tests,were less likely to increase stress even with increased *** found that the spinal cord was prone to external forces,especially in the direction of the fibers,and to be under increased stress levels when the velocity of external forces *** these results,we confirmed that the spinal cord has velocity dependence and *** Institutional Animal Care and Use Committee of Yamaguchi University waived the requirement for ethical approval.