Effects of Copper-Containing Intrauterine Devices on the Endometrium

作     者：Jia-Hui Che Xiao-Ying Yao 

作者机构：Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China 

出 版 物：《Reproductive and Developmental Medicine》 (生殖与发育医学（英文版）)

年 卷 期：2021年第5卷第1期

页      面：38-43页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100404[医学-儿少卫生与妇幼保健学] 10[医学] 

主　　题：Contraception Copper Endometrium Intrauterine Contraception Intrauterine Device 

摘      要：The use of copper-containing intrauterine devices(Cu-IUDs)is a safe,effective,and long-term contraceptive ***,we review the effects of Cu-IUDs on subsequent pregnancy and the morphology,local coagulation function,sensitivity to estrogen and progesterone,cell proliferation,and immune response of the *** on the morphology of endometrium indicate that the use of Cu-IUDs can affect the number and binding capacity of estrogen and progesterone receptors in the endometrium and reduce the response of the endometrium to estrogen and *** use of Cu-IUDs can also affect the proliferation of endometrial cells,suggesting that the aseptic inflammation caused by Cu-IUDs may differ from chronic infectious or noninfectious inflammation;this highlights that the use of Cu-IUDs provides protection against endometrial proliferative *** use of Cu-IUDs increases local endometrial angiogenesis,bleeding tendency,and fibrinolytic activity,which can result in prolonged menstruation or abnormal uterine ***,the use of Cu-IUDs can cause the infiltration of numerous lymphocytes,monocytes,macrophages,and other inflammatory cells around the endometrial gland and changes in endometrial immune function,immune cell function,and the number and type of immune ***-IUD-induced decidual injury significantly increases the invasiveness of trophoblasts,further affecting the aberrant expression of their growth-,angiogenesis-,and invasion-related factors and improving the formation of the ***,the endometrial damage caused by Cu-IUD placement before embryo transfer can improve both clinical pregnancy and live birth rates;however,specific changes in the immune system after Cu-IUD use as well as its effects on future pregnancies require further investigation.