Brain gliomas Biological characteristics and correlation with the status of adjacent corticospinal tracts

作     者：Chaoshi Niu Xiaorui Fei Changxin Wang Jiaming Mei Ying Liu Min Ding 

作者机构：Department of NeurosurgeryAnhui Provincial HospitalAnhui Medical UniversityHefei 230001Anhui ProvinceChina Molecular Neurobiology & Neural Regeneration and Repairing LaboratoryAnhui Provincial Stereotactic Neurosurgical InstituteHefei 230001Anhui ProvineChina Department of RadiologyAnhui Provincial Hospital Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of PathologyAnhui Provincial HospitalAnhui Medical UniversityHefei 230001Anhui ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2010年第5卷第17期

页      面：1347-1352页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 071002[理学-动物学] 

基　　金：Anhui Prov-ince Grant of Tackle Key Problems in Science and Technology  No. 07010302202 

主　　题：brain gliomas corticospinal tracts diffusion tensor imaging fiber tract pathology biology 

摘      要：Malignant behaviors of brain gliomas include proliferation and infiltration.It remains unclear which behavior influences the status of adjacent corticospinal tracts.Diffusion tensor imaging can show the status of brain white matter fiber tracts.Ki-67 and CD44/matrix metalloproteinase 9 are sensitive markers for reflecting the proliferation and infiltration of tumor cells.The present study analyzed pre-operative diffusion tensor images of 24 patients with pathologically confirmed World Health Organization glioma（Ⅰ-Ⅳ）.We observed lapse,infiltration and destruction of the peri-tumor corticospinal tract following reconstruction,and simultaneously detected the expression of Ki-67,CD44/matrix metalloproteinase 9 in samples.Expression of CD44 and matrix metalloproteinase 9was not significantly correlated to the status of the peri-tumor corticospinal tract（r = 1.597,4.859;P = 0.450,0.088）,while Ki-67 expression significantly correlated to its status（r= 6.590,P = 0.037）.These findings demonstrate that highly proliferative gliomas result in damage to the peripheral corticospinal tract.