CRISPR base editor treats premature-aging syndrome

作     者：Ping Lin Jianxin Jiang Min Wu Ping Lin;Jianxin Jiang;Min Wu

作者机构：Wound Trauma Medical CenterState Key Laboratory of TraumaBurns and Combined InjuryDaping HospitalArmy Medical UniversityChongqingChina Department of Biomedical SciencesSchool of Medicine and Health SciencesUniversity of North DakotaGrand ForksNDUSA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第5期

页      面：1410-1412页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学] 

基　　金：This work is supported by National Nature Science Foundation of China Grants 32000033,82020108021 and 81530063 this work is also supported by National Institutes of Health Grants R01 All09317-01A1 and R01 AI138203 this work is also supported by The American Association of Immunologists through a Careers in Immunology Fellowship 

主　　题：CRISPR editor base 

摘      要：A recent paper published in Nature by Koblan et *** the use of CRISPR-mediated adenine base editor(ABE)to repair mutations of the Hutchinson-Gilford progeria syndrome(HGPS or progeria),attenuate symptoms,and extend lifespan of mice(Fig.1),representing a major advance in design of treatments for human accelerated-ageing disorders and potentially other genetic diseases.