Treatment of chronic hepatitis delta virus with peg-interferon and factors that predict sustained viral response

作     者：Shaikh Samiullah Devrajani Bikharam Nasreen 

作者机构：Department of MedicineLiaquat University of Medical and Health SciencesJamshoro/Hyderabad 71000Pakistan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第40期

页      面：5793-5798页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Hepatitis Prevention and Control Program Sindh Pakistan Chief Minister's initiative a government organization provided peg-interferon treatment to patients for 48 wk free of cost 

主　　题：肝炎病毒 干扰素 治疗 应答 预测 生化反应 谷丙转氨酶 慢性 

摘      要：AIM:To observe the efficacy of peg-interferon in the treatment of hepatitis delta virus(HDV) and to identify the factors that would be predictive of the sustained viral response(SVR).METHODS:This prospective study was conducted in Medical Unit Ⅳ of the Liaquat University of Medical and Health Sciences Hospital Jamshoro from June 2008 to September *** study cohort included all patients of either sex who presented during this time with hepatitis B surface antigen positivity,hepatitis B virus DNA 20 000 IU/mL,serum glutamic pyruvic transaminase(SGPT) 2(upper limit of normal),HDV-RNA positivity with fibrosis stage ≥ *** consent was obtained from each of these *** were diagnosed with hepatitis D on the basis of detectable viral antibodies and the presence of HDV-RNA in their serum.A liver biopsy was performed in all cases and fibrosis staging was performed in accordance with the METAVIR scoring *** eligible patients were administered peg-interferon at a weekly dosage of 1.5 g/kg body weight for 48 ***-RNA was assayed at the end of this treatment period and again at 24 wk later.A biochemical response was determined by a normalization of SGPT at the end of the treatment or during follow *** end of treatment response was defined by a HDV-RNA negative status.A sustained virological response was defined by undetectable serum HDV-RNA at six months after the end of ***:Among the 277 patients enrolled in our present study,238 completed a course of peg-interferon therapy of which 180(75.6%) were male and 58(24.4%) *** responses were achieved in 122/238(51.3%) *** of treatment responses were achieved in 71/238(29.8%) cases.A SVR was achieved in 70 of these patients(29.4%).A strong association was found between the SVR and the end of treatment responses(P = 0.001),biochemical responses(P = 0.001) and the degree of fibrosis(P = 0.002).CONCLUSION:Peg-interferon therapy can induce remission in nearly