Healing Effect and Underlying Mechanism of Silver Nanoparticles Prepared Using Carboxymethyl Chitosan under Solar Irradiation

作     者：Yi Long Chunling Zhang Lan Chen Tietao Di Lu Chen Lisha Tang Kaizhong Luo Yu Yan Pingzhen Tong Jie Xiang 

作者机构：College of PharmacyGuizhou University of Traditional Chinese MedicineGuiyang550025China Second Affiliated HospitalGuizhou University of Traditional Chinese MedicineGuiyang550002China Department of Environmental MonitoringChangsha Environmental Protection CollegeChangsha410004China Guizhou Provincial Center for Disease Control and PreventionGuiyang550004China 

出 版 物：《Journal of Renewable Materials》 (可再生材料杂志（英文）)

年 卷 期：2021年第9卷第6期

页      面：1075-1085页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This research was funded by the Science and Technology Fund of Guizhou Province,Grant No.(2016)7125 the National Natural Science Foundation of China,Grant No.81660710 the Natural Science Research Fund of Guizhou Education Department,Grant No.(2017)042 

主　　题：Silver nanoparticle carboxymethyl chitosan low toxicity healing free radical 

摘      要：In our previous study,silver nanoparticles were prepared using AgNO_(3) and carboxymethyl chitosan(CMCS)which is commercially available with solar *** this study,the efficacy and safety of silver nanoparticles prepared by this method were evaluated for healing wounds in rats with *** also attempted to determine the underlying mechanism and influencing factors of the silver nanomaterial preparation *** with growth factors,silver nanoparticles exhibit better healing effects for rats with *** remnant silver ions were detected in the major organs of these rats after the application of silver *** nanoparticles prepared using CMCS are less toxic than those prepared from the conventional method,promote the proliferation of skin fibroblasts,and are promising as a topical medication for infected *** obvious breakage process of the particles is observed during the growth of nanocrystalline silver in *** this study,we also attempted to determine whether this method is suitable for synthesizing silver nanoparticles using N-trimethyl chitosan chloride and sodium alginate were used in this particular *** characteristic UV-vis absorbance peak of silver nanoparticles was found only in the reaction mixture containing N-trimethyl chitosan *** study demonstrates that free radicals are the key factor in this silver nanoparticle preparation method.