Effects of leukemia inhibitory factor on endogenous neural stem cell proliferation and glycoprotein-130 expression in a mouse model of cerebral infarction

作     者：Yufeng Lin Yadan Li Dawei Zang 

作者机构：Graduate School of Tianjin Medical University Tianjin 300070 China Department of Neurology Tianjin First Center Hospital Tianjin 300192 China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第19期

页      面：1452-1456页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071006[理学-神经生物学] 

基　　金：the Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education, No. 1108 the Key Program of Tianjin Health Bureau, No. 06KG05 

主　　题：Leukemia inhibitory factor endogenous neural stem cell glycoprotein-130 cerebral infarction proliferation neural regeneration 

摘      要：Leukemia inhibitory factor （LIF） has been shown to promote proliferation of endogenous neural stem cells. In this study, we treated mice with cerebral infarction using LIF to investigate whether the LIF receptor subunit glycoprotein （gp）130 is involved in neuroprotection. After LIF treatment, the motor function of model mice was significantly improved. Immunofluorescence histochemistry showed increased numbers of endogenous neural stem cells surrounding the infarct foci. Western blot analysis revealed that gp130 expression was significantly decreased surrounding the infarcted foci. Results demonstrated that LIF promoted the proliferation of endogenous neural stem cells by inhibiting gp130 protein expression.