Injectable Self‑Healing Adhesive pH‑Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

作     者：Jiahui He Zixi Zhang Yutong Yang Fenggang Ren Jipeng Li Shaojun Zhu Feng Ma Rongqian Wu Yi Lv Gang He Baolin Guo Dake Chu Jiahui He;Zixi Zhang;Yutong Yang;Fenggang Ren;Jipeng Li;Shaojun Zhu;Feng Ma;Rongqian Wu;Yi Lv;Gang He;Baolin Guo;Dake Chu

作者机构：Department of GastroenterologyThe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anPeople’s Republic of China Frontier Institute of Science and Technologyand State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of StomatologyXi’an Jiaotong UniversityXi’an 710049People’s Republic of China Department of DermatologyThe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi ProvinceFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’anPeople’s Republic of China Department of Experimental SurgeryXijing HospitalFourth Military Medical UniversityXi’anPeople’s Republic of China Department of PathologyTangdu HospitalFourth Military Medical UniversityXi’anPeople’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2021年第13卷第5期

页      面：118-134页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was jointly supported by the National Natural Science Foundation of China(grant Nos.:51973172,51673155,81201927,82002957 and 81672460) the National Key Research and Development Plan of China(No.2018YFC0115300) the State Key Laboratory for Mechanical Behavior of Materials,the World-Class Universities(Disciplines) the Characteristic Development Guidance Funds for the Central Universities,the Natural Science Foundation of Shaanxi Province(No.2020JC-03 and 2019TD-020) the Innovation Talent Promotion Plan of Shaanxi(No.2017KJXX-07) the Key Research and Development Program of Shaanxi Province(No.2019SF-012) the Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University(No.2019LHM-KFKT008) Fundamental Research Funds for the Central Universities of China(No.xjj2018090) 

主　　题：Injectable self-healing hydrogel Adhesive hydrogel Gastric hemostasis Gastric wound healing Endoscopic treatment 

摘      要：Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)are well-established therapeutics for gastrointestinal neoplasias,but complications after EMR/ESD,including bleeding and perforation,result in additional treatment morbidity and even threaten the lives of ***,designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a ***,a series of injectable pH-responsive selfhealing adhesive hydrogels based on acryloyl-6-aminocaproic acid(AA)and AA-g-N-hydroxysuccinimide(AA-NHS)were developed,and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound *** hydrogels showed a suitable gelation time,an autonomous and efficient self-healing capacity,hemostatic properties,and good *** the introduction of AA-NHS as a micro-cross-linker,the hydrogels exhibited enhanced adhesive strength.A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding.A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition,α-SMA expression,and blood vessel *** injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.