Preparation of Chitosan-based Microspheres for Rapid Hemostasis

作     者：Yan Fang Peiyuan Li Weikang Zhou Yan Fang;Peiyuan Li;Weikang Zhou

作者机构：Fujian Provincial Key Laboratory of Polymer MaterialsCollege of Chemistry and Materials ScienceFujian Normal UniversityFuzhouFujian Province350007China 

出 版 物：《Paper And Biomaterials》 (造纸与生物质材料（英文）)

年 卷 期：2021年第6卷第1期

页      面：41-49页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 

基　　金：the Natural Science Foundation of Fujian Province(2019J05059) the Social Development of Instructive Program of Fujian Province(2017Y0025) 

主　　题：chitosan microspheres hemostasis wet-tissue adhesion 

摘      要：Rapid control of heavy hemorrhaging is critical to save the life of injured ***,we developed a novel hemostat employing chitosan-based microspheres,which was prepared by sequential microemulsion of chitosan solution,sol-gel phase transition,and surface modification by 3,4-dihydroxyhydrocinnamic acid(HCA).HCA-modified chitosan microspheres(CSMS-HCA)displayed a porous structure,with a high specific surface area(~211.3 m^(2)/g),accelerating their rapid absorption of blood and concentrating red cells and *** CSMS-HCA exhibited much better in vitro and in vivo hemostatic efficacy than porous chitosan microspheres *** a rapid hemostat in the form of microspheres is highly effective in treating deep and irregular wounds,owing to easy accessibility to injured sites.