Cohort study of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis in China:evaluation of risk models and new predictor of pulmonary consolidation on computed tomography

作     者：Yanhong Shou Lu Yang Yongsheng Yang Xiaohua Zhu Feng Li Bo Yin Yingyan Zheng Jinhua Xu Yanhong Shou;Lu Yang;Yongsheng Yang;Xiaohua Zhu;Feng Li;Bo Yin;Yingyan Zheng;Jinhua Xu

作者机构：Department of DermatologyHuashan HospitalFudan UniversityShanghai 200040China Department of RadiologyHuashan HospitalFudan UniversityShanghai 200040China Shanghai Institute of DermatologyShanghai 200040China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2021年第15卷第4期

页      面：585-593页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100206[医学-皮肤病与性病学] 10[医学] 

基　　金：This research was supported by a grant from the National Natural Science Foundation of China(No.81673060) 

主　　题：Stevens-Johnson syndrome toxic epidermal necrolysis auxiliary score ABCD-10 pulmonary consolidation 

摘      要：Stevens-Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)are rare but severe *** study aimed to validate the predictive ability of risk models in patients with SJS/TEN and propose possible refinement in *** in the Department of Dermatology of Huashan Hospital from January 2008 to January 2019 were *** showed that the severity-of-illness score for TEN(SCORTEN)had a good discrimination(area under the receiver operating characteristic curve(AUC),0.78),and it was superior to auxiliary score(AS)and ABCD-10,which indicates age,bicarbonate level,cancer,dialysis,and 10%involved body surface area(AUC,0.69 and 0.68,respectively).The calibration of SCORTEN(Hosmer-Lemeshow goodness-of-fit test,P=0.69)was also better than that of AS(P=0.25)and ABCD-10(P=0.55).SCORTEN and ABCD-10 were similar(Brier score(BS),0.04 and 0.04)in terms of accuracy of *** addition,the imaging appearance of pulmonary consolidation on computed tomography was associated with high *** models were formed using the variables and this imaging *** refined AS and ABCD-10 models were similar in discrimination compared with the original SCORTEN(0.74 vs.0.78,P=0.23;0.74 vs.0.78,P=0.30,respectively).Therefore,SCORTEN showed good discrimination performance,calibration,and accuracy,and refined AS or ABCD-10 model may be an option when SCORTEN variables are not available.