The regulation of protein translation and its implications for cancer
作者机构：Department of Medical OncologyCancer Institute of Zhejiang UniversitySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Hepatobiliary and Pancreatic SurgeryFirst Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Key Lab of Biotherapy in ZhejiangSir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiangChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2021年第6卷第3期
页 面：734-742页
核心收录：
学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术]
基 金：supported by National Natural Science Foundation of China(91740106 81772944 81672723 81672360)
主 题：translation such summarized
摘 要：In addition to the deregulation of gene transcriptions and post-translational protein modifications,the aberrant translation from,mRNAs to proteins plays an important role in the pathogenesis of various *** mRNA translation are expected to become potential approaches for anticancer *** translation is affected by many factors including translation initiation factors and RNA-binding ***,modifications of mRNAs mainly N6-methyladenine(m6A)modification and noncoding RNAs,such as microRNAs and long noncoding RNAs are *** this review,we generally summarized the recent advances on the regulation of protein translation by the interplay between mRNA modifications and *** doing so,we hope this review could offer some hints for the development of novel approaches in precision therapy of human cancers.
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