Missing for partnership: understanding nucleosomal de novo DNA cytosine methylation by a spliced DNMT3 complex
作者机构：MOE Key Laboratory of Protein SciencesBeijing Advanced Innovation Center for Structural BiologyTsinghua-Peking Center for Life SciencesSchool of MedicineTsinghua UniversityBeijingChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2021年第6卷第2期
页 面：209-210页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the China National Fund for Distinguished Young Scholars(Grant No.31725014)
主 题：al. somal chromosomal
摘 要：In a recent paper published in Nature,Xu et *** a cryo-EM structure of a,spliced,de novo DNA methyltransferase complex,DNMT3A2-DNMT3B3,bound to a mono-nucleosome with extended linker DNA.1 Reinforced by biochemical assays and genomic studies,this structure reveals the molecular mechanism underlying de novo cytosine methylation on nucleosomal ***,the catalytically inactive DNMT3B3 occupies the nucleosome core and orients the active DNMT3A2 to target the linker DNA as its substrate,suggesting the necessity of chromosomal remodeler in the deposition of DNA methylation on nucleosomes.
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