Raman spectroscopy as process analytical tool in downstream processing of biotechnology

作     者：Yu Kiat Lin Hui Yi Leong Tau Chuan Ling Dong-Qiang Lin Shan-Jing Yao Yu Kiat Lin;Hui Yi Leong;Tau Chuan Ling;Dong-Qiang Lin;Shan-Jing Yao

作者机构：Key Laboratory of Biomass Chemical Engineering of Ministry of EducationCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Institute of Biological SciencesFaculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2021年第34卷第2期

页      面：204-211页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 0817[工学-化学工程与技术] 08[工学] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：This work was supported by the National Natural Science Foundation of China(No.21878263 22078286) 

主　　题：Raman spectroscopy Process analytical technology Downstream bioprocessing Biotechnology 

摘      要：Downstream processing or product recovery plays a vital role in the development of *** improve the bioprocess efficiency,some unconventional methods are much *** continuous manufacturing in downstream processing makes the Process Analytical Technologies(PATs)as an important *** and controlling bioprocess are an essential factor for the principles of PAT and quality by *** methods can apply to monitor multiple analytes in real-time with less sample processing with significant *** spectroscopy is an extensively used technique as an analytical and research tool owing to its modest process form,non-destructive,non-invasive optical molecular spectroscopic imaging with computer-based ***,its application is essential for the analysis and characterization of biological samples,and it is easy to operate with minimal *** innovation on various types of enhanced Raman spectroscopy was designed to enhance the Raman analytical *** spectroscopy could couple with chemometrics to provide reliable alternative analysis method of downstream process ***,this review aims to provide useful insight on the application of Raman spectroscopy for PAT in downstream processing of biotechnology and Raman data analysis in biological fields.