Thin films of binary amorphous Zn-Zr alloys developed by magnetron co-sputtering for the production of degradable coronary stents:A preliminary study
作者机构：Laboratoire de Science des Materiaux et des ProcedesUPR CNRS 3407Universite Paris 13Sorbonne-Paris-CiteInstitut Galilee99 av J.B.Clement93430VilletaneuseFrance Laboratory for Vascular Translational ScienceInserm U1148Universite Paris 13Universite Paris-DiderotSorbonne-Paris-CiteInstitut Galilee99 av J.B.Clement93430VilletaneuseFrance Institut des Materiaux Jean Rouxel(IMN)UMR CNRS 6502Universite de Nantes2rue de la HoussiniereB.P.3222944322Nantes Cedex 3France
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2018年第3卷第4期
页 面：385-388页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程]
摘 要：1.Introduction Vascular stents are endo-prostheses that allow the restoration of blood flow in case of obstruction of a vessel.A stent usually consists of a corrosion-resistant metal such as Nitinol,316L steel or a CoCr alloy[1].Many studies have been undertaken for the production of polymer degradable stents[2,3]or metallic stents[4,5]and,among these,devices made of pure zinc or crystallized alloy based on zinc obtained by molding and extrusion are promising in terms of biodegradability,biocompatibility and mechanical properties[6],but also concerning the degradation rate of the stent which should to be effective until arterial remodeling and tissue healing are complete[5].The objective of this preliminary study is the comparison of the degradation in simulated biological medium and the endothelial cytotoxicity of amorphous and crystallized thin ZnZr films according to their composition and structure.In this work,the thin layers were deposited on silicon substrates by magnetron co-sputtering.This technology is already used to make metal stents[7,8].
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