Self-adhesive lubricated coating for enhanced bacterial resistance
作者机构：State Key Laboratory of TribologyDepartment of Mechanical EngineeringTsinghua UniversityBeijing100084China Central LaboratoryPeking University School and Hospital of StomatologyBeijing100081China Beijing Research Institute of Automation for Machinery Industry Co.LtdBeijing100120China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2021年第6卷第8期
页 面：2535-2545页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：supported by National Natural Science Foundation of China(52022043) Tsinghua University Initiative Scientific Research Program(20197050026) Precision Medicine Foundation,Tsinghua University,China(10001020120) Capital’s Funds for Health Improvement and Research(2020-2Z-40810) Research Fund of State Key Laboratory of Tribology,Tsinghua University,China(SKLT2020C11)
主 题：Dopamine Lubrication Biomimetic coating Bacterial resistance Self-adhesive
摘 要：Limited surface lubrication and bacterial biofilm formation pose great challenges to biomedical *** hydrophilic lubricated coatings and bacterial resistance coatings have been reported,the harsh and tedious synthesis greatly compromises their application,and more importantly,the bacterial resistance property has seldom been investigated in combination with the lubrication *** this study,bioinspired by the performances of mussel and articular cartilage,we successfully synthesized self-adhesive lubricated coating and simultaneously achieved optimal lubrication and bacterial resistance ***,we reported the mechanism of bacterial resistance on the nanoscale by studying the adhesion interactions between biomimetic coating and hydrophilic/hydrophobic tip or living bacteria via atomic force *** summary,the self-adhesive lubricated coating can effectively enhance lubrication and bacterial resistance performances based on hydration lubrication and hydration repulsion,and represent a universal and facial strategy for surface functionalization of biomedical implants.
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