Circular RNA AKT3 governs malignant behaviors of esophageal cancer cells by sponging miR-17-5p
作者机构：Department of Hepatobiliary and Pancreatic SurgeryChina-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Colorectal SurgeryChina-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of HematologyJilin Province Blood CenterChangchun 130000Jilin ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第3期
页 面：240-254页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Esophageal cancer Circular RNA AKT3 miR-17-5p Proliferation Migration Invasion
摘 要：BACKGROUND Recent studies have demonstrated that circular RNA AKT3(circAKT3)plays a crucial role in regulating the malignant phenotypes of tumor ***,the potential effects of circAKT3 on esophageal cancer have not been *** To illuminate the role of circAKT3 in malignant behaviors of esophageal cancer cells and its underlying *** Clinical samples were collected to detect the expression of *** role of circAKT3 in proliferation,migration,invasion,and apoptosis of esophageal cancer cells was evaluated using Cell Counting Kit-8,wound healing assays,Transwell assays,and fluorescence analysis,*** target of circAKT3 was screened and identified using an online database and luciferase reporter assay.A xenograft nude mouse model was established to investigate the role of circAKT3 in *** In vitro assays showed that proliferative,migratory,and invasive capacities of esophageal cancer cells were significantly enhanced by circAKT3 ***,miR-17-5p was screened as the target of circAKT3,and miR-17-5p antagonized the effects of circAKT3 on esophageal cancer ***,we identified RHOC and STAT3 as the direct target molecules of miR-17-5p,and circAKT3 facilitated expression of RHOC and STAT3 by inhibiting *** vivo assays showed circAKT3 knockdown inhibited growth of esophageal *** CircAKT3 contributed to the malignant behaviors of esophageal cancer in vitro and in vivo by sponging miR-17-5p thus providing a potential target for treatment of esophageal cancer.
维普期刊数据库