Arylalkalamine N-acetyltransferase-1 functions on cuticle pigmentation in the yellow fever mosquito,Aedes aegypti
作者机构：Laboratory of Tropical Veterinary Medicine and Vector BiologySchool of Life and Pharmaceutical SciencesHainan UniversityHaikou570228China
出 版 物：《Insect Science》 (昆虫科学（英文版）)
年 卷 期：2021年第28卷第6期
页 面：1591-1600页
核心收录：
学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 09[农学] 0904[农学-植物保护] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 0713[理学-生态学]
基 金：supported by National Natural Science Foundation of China(31860702 31960703) Postgraduate Innovation Research Project of General Higher Education in Hainan Province,China(Hyb2018-08)
主 题：arylalkylamine Aedes aegypti CRISPR-Cas9 cuticle pigmentation gene expression N-acetyltransferase
摘 要：Arylalkylamine N-acetyltransferase(aaNAT)catalyzes the acetylation of dopamine,5-hydroxy-tryptamine,tryptamine,octopamine,norepinephrine and other ary-lalkylamines to form respective *** on the products formed,aaNATs are involved in a variety of physiological *** the yellow fever mosquito,Aedes aegypti,a number of aaNATs and aaNAT-like proteins have been ***,the primary function of each individual aaNAT is yet to be *** this study we investigated the function of *** aaNAT 1(Ae-aaNATl)in cuticle pigmentation and development of ***-aaNAT1 transcripts were detected at all stages of development with highest expressions after pupation and right before adult ***-aaNATl mutant mosquitoes generated using clustered regularly interspaced palindromic repeats(CRISPR)-CRISPR-associated protein 9 had no obvious effect on larval and pupal ***,the mutant mosquitoes exhibited a roughened ex-oskeletal surface,darker cuticles,and color pattern changes suggesting that Ae-aaNAT1 plays a role in development of the morphology and pigmentation of *** adult *** mutant also showed less blood feeding efficiency and lower fecundity when compared with the *** mutation of Ae-aaNAT1 influenced expression of genes involved in cuticle *** summary,Ae-aaNAT1 mainly functions on cuticular pigmentation and also affects blood feeding efficiency and fecundity.
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