The relation between HLA-DQA1 genes and genetic susceptibility to duodenal ulcer in Wuhan Hans

作     者：Du YP Deng CS Lu DY Huang MF Guo SF Hou W 

作者机构：Department of Gastroenterologythe Second Affiliated HospitalHubei Medical UniversityWuhan 430071Hubei ProvinceChina Department of Clinical CancerInstitute of Virus Research of Basic MedicineHubei Medical UniversityWuhan 430071Hubei ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2000年第6卷第1期

页      面：107-110页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Subject headings duodenal ulcer HLA-DQA1 gene polymerase chain reaction restricted fragment length polymorphism genetic susceptibility 

摘      要：AIM To study the genetic susceptibility of HLA-DQA1 alleles to duodenal ulcer in Wuhan *** Seventy patients with duodenalulcer and fifty healthy controls were examinedfor HLA-DQA1 ***-DQA1 typing wascarried out by digesting the locus specificpolymerase chain reaction amplified productswith alleles specific restriction enzymes(PCR-RFLP),i.e.,Apal Ⅰ,Bsaj Ⅰ,Hph Ⅰ,Fok Ⅰ,Mbo Ⅱ and Mnl Ⅰ.RESULTS The allele frequencies of DQA1 * 0301and DQA1 * 0102 in patients with duodenal ulcerwere significantly higher and lower respectivelythan those in healthy controls(0.40 vs 0.20,P = 0.003,mcorret = 0.024)and(0.05 vs 0.14,P = 0.012,but Pcorret0.05),*** DQA1 * 0301 is a susceptiblegene for duodenal ulcer in Wuhan Hans,andthere are immunogenetic differences in HLA-DQA1 locus between duodenal ulcer patients andhealthy controls.