1例皮肤Rosai-Dorfman病发生结晶沉积

作     者：Motta L. McMenamin M.E. Thomas M.A. Calonje E. 惠海英 

作者机构：Dr. Department of Histopathology St. John' s Institute of Dermatology St. Thomas' Hospital LondonUnited Kingdom 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2005年第1卷第12期

页      面：29-30页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：组织细胞 中性粒细胞浸润 炎性细胞 淋巴结外 免疫染色 播散性 轻链 共生现象 

摘      要：Rosai- Dorfman Disease (RDD) is an idiopathic reactive proliferation of distinctive histiocytes that have abundant cytoplasm and commonly exhibit intracytoplasmic ingestion of inflammatory cells (emperipolesis). The histiocytes are immunopositive for S100 protein and are typically associated with an infiltrate of lymphocytes, plasma cells, and neutrophils. The classic clinical presentation is massive enlargement of (usually) cervical lymph nodes with a histologic appearance that mimics exaggerated sinus histiocytosis. RDD can also involve extranodal sites and skin involvement is common either as part of disseminated disease or as a result of primary disease. We report an exceptional case of cutaneous RDD with crystal deposition in a young male presenting with skin nodules. Skin biopsy showed classic features of cutaneous RDD with the additional feature of conspicuous rhomboidal and needle- shaped crystals within the cytoplasm of many lesional plasma cells, histiocytes, and also in an extracellular location. The plasma cells were polyclonal by light chain immunostaining. Crystal deposition has not been reported to date in RDD and is likely a result of the reactive plasma cell proliferation.