Microfluidic interface boosted synthesis of covalent organic polymer capsule

作     者：Yun Zhao Min Zhang Xin Wen Zhonghua Xiang Yun Zhao;Min Zhang;Xin Wen;Zhonghua Xiang

作者机构：State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing100029PR China 

出 版 物：《Green Chemical Engineering》 (绿色化学工程（英文）)

年 卷 期：2020年第1卷第1期

页      面：63-69页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the National Key Research and Development Program of China(2019YFA0210300) NSF of China(21676020,21922802) the Beijing Natural Science Foundation(JQ19007) the Young Elite Scientists Sponsorship Program by CAST(2017QNRC001) Talent cultivation and open project(OIC-201801007)of State Key Laboratory of Organic-Inorganic Composites “Double-First-Class”construction projects(XK180301,XK1804-02) Distinguished Scientist Program at BUCT(buctylkxj02) 

主　　题：Covalent organic polymers Microcapsules Interfacial synthesis Microfluidic system High throughput 

摘      要：Microcapsules have been widely used in drug carriers,nano/microreactors,artificial organelles for their empty space and functional *** synthesized from spherical liquid-liquid interface show ultrathin shell and large ***,spherical liquid-liquid interfaces generated by stirring or sonicating are difficult in controlling the droplet size and preventing their coalescence,which results in inhomogeneous ***,we demonstrate a microfluidic interfacial synthetic method to produce microcapsules using the hot covalent organic polymers(COPs)coupled with Schiff-base reaction.A very high throughput of uniform and individual microdroplets about~1400 min^(-1)was generated under high flow rate for COP capsules *** catalyst promoted amine and aldehyde condensation that reacted less than 1 s assured the polymerization occurred at the liquid-liquid interface regardless of the diffusion intensification in microfluidic *** capsules with shell thickness around 50 nm were flexible enough to response to slight interior capillary force and exterior filtration force to form origami structure and sealed flat membrane,*** of the interfacial synthesized capsule expressed large capacity by encapsulating 1.41×10^(-2)μg SiO_(2)nanoparticles as theoretically ***,these properties make the COP capsules promising in,but not limited to,fast drug delivery and microreactors.