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A unified fractional flow framework for predicting the liquid holdup in two-phase pipe flows

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Petroleum Science 2024年第4期21卷 2614-2624页

作者： Fuqiao Bai Yingda Lu Mukul M.Sharma Hildebrand Department of Petroleum and Geosystems Engineering The University of Texas at Austin

Two-phase pipe flow occurs frequently in oil & gas industry, nuclear power plants, and CCUS. Reliable calculations of gas void fraction(or liquid holdup) play a central role in two-phase pipe flow models. In this paper we apply the fractional flow theory to multiphase flow in pipes and present a unified modeling framework for predicting the fluid phase volume fractions over a broad range of pipe flow conditions. Compared to existing methods and correlations, this new framework provides a simple,approximate, and efficient way to estimate the phase volume fraction in two-phase pipe flow without invoking flow patterns. Notably, existing correlations for estimating phase volume fraction can be transformed and expressed under this modeling framework. Different fractional flow models are applicable to different flow conditions, and they demonstrate good agreement against experimental data within 5% errors when compared with an experimental database comprising of 2754 data groups from 14literature sources, covering various pipe geometries, flow patterns, fluid properties and flow *** gas void fraction predicted by the framework developed in this work can be used as inputs to reliably model the hydraulic and thermal behaviors of two-phase pipe flows.

关键词： Pipe fractional flow Liquid holdup Multiphase pipe flow Gas void fraction

An inverse analysis of fluid flow through granular media using differentiable lattice Boltzmann method

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2077-2090页

作者： Qiuyu Wang Krishna Kumar Department of Civil Architectural and Environmental EngineeringUniversity of Texas at AustinAustin78712-2100USA

This study presents a method for the inverse analysis of fluid flow *** focus is put on accurately determining boundary conditions and characterizing the physical properties of granular media,such as permeability,and fluid components,like *** primary aim is to deduce either constant pressure head or pressure profiles,given the known velocity field at a steady-state flow through a conduit containing obstacles,including walls,spheres,and *** lattice Boltzmann method(LBM)combined with automatic differentiation(AD)(AD-LBM)is employed,with the help of the GPU-capable Taichi programming language.A lightweight tape is used to generate gradients for the entire LBM simulation,enabling end-to-end *** AD-LBM approach accurately estimates the boundary conditions for complex flow paths in porous media,leading to observed steady-state velocity fields and deriving macro-scale permeability and fluid *** method demonstrates significant advantages in terms of prediction accuracy and computational efficiency,making it a powerful tool for solving inverse fluid flow problems in various applications.

关键词： Inverse problem Fluid flow Granular media Automatic differentiation(AD) Lattice Boltzmann method(LBM)

Design and synthesis of synthetic promoters for consistency of gene expression across growth phases and scale in ***

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Synthetic and Systems Biotechnology 2024年第2期9卷 330-339页

作者： Kristin V.Presnell Omar Melhem Sarah M.Coleman Nicholas J.Morse Hal S.Alper McKetta Department of Chemical Engineering The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX78712USA Institute for Cellular and Molecular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX78712USA

Metabolic engineering and synthetic biology endeavors benefit from promoters that perform consistently(or robustly)with respect to cellular growth phase(exponential and stationary)and fermentation scale(microtiter plates,tubes,flasks,and bioreactors).However,nearly all endogenous promoters(especially in Saccharomyces cerevisiae)do not perform in this *** this work,a hybrid promoter engineering strategy is leveraged to create novel synthetic promoters with robustness across these *** a multi-dimensional RNA-seq dataset,promoters with specific phase dependencies were *** enriched with functional transcription factors were identified using MEME *** motif-containing fragments could impart activity dependence in the opposing ***,we obtain two new promoters with high and consistent expression across both phases by increasing the exponential phase activity of the starting stationary-phase scaffold by 38 and 23-fold ***,we show that these promoters function consistently across various laboratory growth scales over time in a microtiter plate and in ***,this work presents and validates a new strategy for engineering promoters in *** with high levels of expression that are robust to cellular growth phase and the scale of the culture.

关键词： endogenous synthetic stationary

Silicon-photonics-enabled chip-based 3D printer

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Light(Science & Applications) 2024年第7期13卷 1320-1330页

作者： Sabrina Corsetti Milica Notaros Tal Sneh Alex Stafford Zachariah A.Page Jelena Notaros Research Laboratory of Electronics Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Chemistry The University of Texas at AustinAustinTX 78712USA

Imagine if it were possible to create 3D objects in the palm of your hand within seconds using only a single photonic *** 3D printing has revolutionized the way we create in nearly every aspect of modern society,current 3D printers rely on large and complex mechanical systems to enable layer-by-layer addition of *** limits print speed,resolution,portability,form factor,and material *** there have been recent efforts in developing novel photocuring-based 3D printers that utilize light to transform matter from liquid resins to solid objects using advanced methods,they remain reliant on bulky and complex mechanical *** address these limitations,we combine the fields of silicon photonics and photochemistry to propose the first chip-based 3D *** proposed system consists of only a single millimeter-scale photonic chip without any moving parts that emits reconfigurable visible-light holograms up into a simple stationary resin well to enable non-mechanical 3D ***,we experimentally demonstrate a stereolithography-inspired proof-of-concept version of the chip-based 3D printer using a visible-light beam-steering integrated optical phased array and visible-light-curable resin,showing 3D printing using a chip-based system for the first *** work demonstrates the first steps towards a highlycompact,portable,and low-cost solution for the next generation of 3D printers.

关键词： printer printing visible

New complex physiological findings evolve hypothesized mechanisms of Dravet syndrome

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Neural Regeneration Research 2024年第9期19卷 1867-1868页

作者： MacKenzie A.Howard Department of Neurology Dell Medical SchoolAustinTXUSA Center for Learning and Memory and Department of Neuroscience University of Texas at AustinAustinTXUSA

Developmental and epileptic encephalopathies(DEEs)are neurological disorders generally involving medically intractable seizures and a diverse array of comorbid neuropsychiatric delays and deficits that may severely affect cognition,mood,sleep,social behavior,movement control,learning,and/or *** syndrome(DS),also known as Severe Myoclonic Epilepsy of Infancy.

关键词： sized finding seizures

Accuracy comparison and improvement for state of health estimation of lithium-ion battery based on random partial recharges and feature engineering

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Journal of Energy Chemistry 2024年第5期92卷 591-604页

作者： Xingjun Li Dan Yu Søren Byg Vilsen Daniel Ioan Stroe Department of Energy Aalborg UniversityAalborg 9220Denmark Department of Mathematical Sciences Aalborg UniversityAalborg 9220Denmark Walker Department of Mechanical Engineering The University of Texas at AustinAustinTX 78712USA

State of health(SOH)estimation of e-mobilities operated in real and dynamic conditions is essential and *** of existing estimations are based on a fixed constant current charging and discharging aging profiles,which overlooked the fact that the charging and discharging profiles are random and not complete in real *** work investigates the influence of feature engineering on the accuracy of different machine learning(ML)-based SOH estimations acting on different recharging sub-profiles where a realistic battery mission profile is *** features were extracted from the battery partial recharging profiles,considering different factors such as starting voltage values,charge amount,and charging sliding ***,features were selected based on a feature selection pipeline consisting of filtering and supervised ML-based subset *** linear regression(MLR),Gaussian process regression(GPR),and support vector regression(SVR)were applied to estimate SOH,and root mean square error(RMSE)was used to evaluate and compare the estimation *** results showed that the feature selection pipeline can improve SOH estimation accuracy by 55.05%,2.57%,and 2.82%for MLR,GPR and SVR *** was demonstrated that the estimation based on partial charging profiles with lower starting voltage,large charge,and large sliding window size is more likely to achieve higher *** work hopes to give some insights into the supervised ML-based feature engineering acting on random partial recharges on SOH estimation performance and tries to fill the gap of effective SOH estimation between theoretical study and real dynamic application.

关键词： Feature engineering Dynamic forklift aging profile State of health comparison Machine learning Lithium-ion batteries

Differences between lower extremity joint running kinetics captured by marker-based and markerless systems were speed dependent

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Journal of Sport and Health Science 2024年第4期13卷 569-578页

作者： Hui Tang Barry Munkasy Li Li Department of Health Sciences and Kinesiology Georgia Southern UniversityStatesboroGA 30458USA Department of Kinesiology and Health Education University of Texas at AustinAustinTX 78712USA

Background:The development of computer vision technology has enabled the use of markerless movement tracking for biomechanical *** research has reported the feasibility of markerless systems in motion analysis but has yet to fully explore their utility for capturing faster movements,such as *** studies using markerless systems in clinical and sports settings are still ***,the present study compared running biomechanics estimated by marker-based and markerless *** running speed not only affects sports performance but is also associated with clinical injury prevention,diagnosis,and rehabilitation,we aimed to investigate the effects of speed on the comparison of estimated lower extremity joint moments and powers between markerless and marker-based technologies during treadmill running as a concurrent validating ***:Kinematic data from marker-based/markerless technologies were collected,along with ground reaction force data,from 16 young adults running on an instrumented treadmill at 3 speeds:2.24 m/s,2.91 m/s,and 3.58 m/s(5.0 miles/h,6.5 miles/h,and 8.0 miles/h).Sagittal plane moments and powers of the hip,knee,and ankle were calculated by inverse dynamic *** series analysis and statistical parametric mapping were used to determine system ***:Compared to the marker-based system,the markerless system estimated increased lower extremity joint kinetics with faster speed during the swing phase in most ***:Despite the promising application of markerless technology in clinical settings,systematic markerless overestimation requires focused *** on segment pose estimations,the centers of mass estimated by markerless technologies were farther away from the relevant distal joint centers,which led to greater joint moments and powers estimates by markerless ***-based *** differences were amplified by running speed.

关键词： Biomechanics Motion capture Gait Statistical parametric mapping

Systematic review of the efficacy of data-driven urban building energy models during extreme heat in cities:Current trends and future outlook

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Building Simulation 2024年第5期17卷 695-722页

作者： Nilabhra Mondal Prashant Anand Ansar Khan Chirag Deb David Cheong Chandra Sekhar Dev Niyogi Mattheos Santamouris Department of Architecture and Regional Planning Indian Institute of Technology KharagpurKharagpurIndia Department of Geography Lalbaba CollegeUniversity of CalcuttaKolkataIndia School of Architecture Design and PlanningThe University of SydneyAustralia Department of the Built Environment National University of SingaporeSingapore Department of Geological Sciences Jackson School of GeosciencesThe University of Texas at AustinAustinUSA DepartmentofCivil Architecturaland Environmental EngineeringThe Universityof Texas at AustinAustinUSA Faculty of Built Environment University of New South WalesAustralia

Energy demand fluctuations due to low probability high impact(LPHI)micro-climatic events such as urban heat island effect(UHI)and heatwaves,pose significant challenges for urban infrastructure,particularly within urban *** short term load forecasting(STLF)of buildings in urban micro-climatic setting(UMS)is obscured by the complex interplay of surrounding morphology,micro-climate and inter-building energy *** urban building energy modelling(UBEM)approaches to provide quantitative insights about building energy consumption often neglect the synergistic impacts of micro-climate and urban morphology in short temporal *** order modelling,unavailability of rich urban datasets such as building key performance indicators for building archetypes-characterization,limit the inter-building energy dynamics consideration into *** addition,mismatch of resolutions of spatio-temporal datasets(meso to micro scale transition),LPHI events extent prediction around UMS as well as its accurate quantitative inclusion in UBEM input organization step pose another degree of *** review aims to direct attention towards an integrated-UBEM(i-UBEM)framework to capture the building load fluctuation over multi-scale spatio–temporal *** highlights usage of emerging data-driven hybrid approaches,after systematically analysing developments and limitations of recent physical,data-driven artificial intelligence and machine learning(AI-ML)based modelling *** also discusses the potential integration of google earth engine(GEE)-cloud computing platform in UBEM input organization step to(i)map the land surface temperature(LST)data(quantitative attribute implying LPHI event occurrence),(ii)manage and pre-process high-resolution spatio-temporal UBEM *** the potential of digital twin,central structed data models to integrate along UBEM workflow to reduce uncertainties related to building archetype characterizat

关键词： urban heat island(UHI) urbanmicro-climate urban morphology urban building energy modelling(UBEM) digitaltwin shorttermload forecasting(STLF) googleearthengine(GEE)

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration