检索结果-南通市图书馆

Neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-Lagarde Narimène Asbelaoui Abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry Timothy Barrett Sovan Sarkar I-STEM CECSCorbeil-EssonnesFrance universitéparis-saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute of Cancer and Genomic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

Energy based 3D trajectory tracking control of quadrotors with model-free based on-line disturbance compensation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2018年第7期31卷 1568-1578页

作者： Yasser BOUZID Houria SIGUERDIDJANE Yasmina BESTAOUI IBISC Laboratory Université d'Evry Val d'Essonne Université Paris-Saclay L2S CentraleSupélecUniversité Paris-Saclay

In this work, a Revisited form of the so-called Model-Free Control（R-MFC） is ***, the MFC principle is employed to deal with the unknown part of a plant only（i.e., unmodeled dynamics, disturbances, etc.） and occurs beside an Interconnection and Damping AssignmentPassivity Based Control（IDA-PBC） strategy. Using the proposed formulation, it is shown that we can significantly improve the performance of the control through the reshaping properties of the IDA-PBC technique. Moreover, the control robustness level is increased via a compensation of the time-varying disturbances and the unmodeled system dynamics. This on-line compensation capability is provided by the MFC principle. The problem is studied in the case of Multi-Input Multi-Output（MIMO） mechanical systems with an explicit application to a small Vertical Take-Off and Landing（VTOL） Unmanned Aerial Vehicle（UAV） where a stability analysis is also provided. Numerical simulations have shown satisfactory results, in comparison with some other control strategies, where an in-depth discussion with respect to the control performance is highlighted by considering several scenarios and using several metrics.

关键词： IDA-PBC Model-free control Nonlinear flight control Robust control Trajectory tracking

Preface to special topic on information and intelligent metasurfaces

在线全文

学校读者我要写书评

暂无评论

National Science Review 2023年第8期10卷 7-8页

作者： Tie Jun Cui Marco Di Renzo Southeast university université paris-saclay

In the past decades, information science and technology has developed rapidly, but has also encountered some *** further development requires some original driving force of underlying physics(such as quantum mechanics...

关键词：

Raman-Brillouin interplay for inertial confinement fusion relevant laser-plasma interaction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2016年第3期4卷 23-38页

作者： C.Riconda S.Weber LULI-UPMC universitparis 6:Sorbonne universits CNRSEcole PolytechniqueCEA:Universit Paris-Saclay Institute of Physics of the ASCR

The co-existence of the Raman and Brillouin backscattering instability is an important issue for inertial confinement fusion. The present paper presents extensive one-dimensional(1D) particle-in-cell(PIC) simulations for a wide range of parameters extending and complementing previous findings. PIC simulations show that the scenario of reflectivity evolution and saturation is very sensitive to the temperatures, intensities, size of plasma and boundary conditions employed. The Langmuir decay instability is observed for rather small k_(epw)λ_D but has no influence on the saturation of Brillouin backscattering, although there is a clear correlation of Langmuir decay instability modes and ion-fractional decay for certain parameter ranges. Raman backscattering appears at any intensity and temperature but is only a transient phenomenon. In several configurations forward as well as backward Raman scattering is observed. For the intensities considered, I λ_o^2 above 10^(15) W μm^2/cm^2, Raman is always of bursty nature. A particular setup allows the simulation of multi-speckle aspects in which case it is found that Raman is self-limiting due to strong modifications of the distribution function. Kinetic effects are of prime importance for Raman backscattering at high temperatures. No unique scenario for the saturation of Raman scattering or Raman–Brillouin competition does exist. The main effect in the considered parameter range is pump depletion because of large Brillouin backscattering. However, in the low k_(epw)λ_D regime the presence of ion-acoustic waves due to the Langmuir decay instability from the Raman created electron plasma waves can seed the ion-fractional decay and affect the Brillouin saturation.

关键词： Brillouin backscattering inertial confinement fusion kinetic effects laser-plasma interaction parametric instabilities particle-in-cell simulations Raman backscattering

Plasmonics of regular shape particles,a simple group theory approach

在线全文

学校读者我要写书评

暂无评论

Nano Research 2020年第6期13卷 1597-1603页

作者： Sarra Mitiche Sylvie Marguet Fabrice Charra Ludovic Douillard université paris-saclay CEACNRSSPECF-91191Gif sur YvetteFrance université paris-saclay CEACNRSNIMBEF-91191Gif sur YvetteFrance

A simple hand calculation method based on group theory is proposed to predict the near field maps of finite metallic nanoparticles(MNP)of canonical geometries:prism,cube,hexagon,disk,sphere,*** to low order localized surface plasmon resonance *** this article,we report the principles of the group theory approach and demonstrate,through several examples,the general character of the group theory method which can be applied to describe the plasmonic response of particles of finite or infinite symmetry point *** validation is achieved by collection of high-resolution subwavelength near-field maps by photoemission electron microscopy(PEEM)on a representative set of Au colloidal particles exhibiting either finite(hexagon)or infinite(disk,sphere)symmetry point groups.

关键词： surface plasmon resonance group theory hexagon disk sphere photoemission electron microscopy(PEEM)

Numerical Analysis for an Energy-stable Total Discretization of a Poromechanics Model with Inf-sup Stability

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2019年第1期35卷 28-53页

作者： B.BURTSCHELL P.MOIREAU D.CHAPELLE Inria Université Paris-Saclay LMS Ecole PolytechniqueCNRS

We consider a previously proposed general nonlinear poromechanical formulation, and we derive a linearized version of this model. For this linearized model, we obtain an existence result and we propose a complete discretization strategy – in time and space – with a special concern for issues associated with incompressible or nearly-incompressible behavior. We provide a detailed mathematical analysis of this strategy,the main result being an error estimate uniform with respect to the compressibility parameter. We then illustrate our approach with detailed simulation results and we numerically investigate the importance of the assumptions made in the analysis, including the fulfillment of specific inf-sup conditions.

关键词： poromechanics incompressibility total discretization inf-sup energy estimates

Focus on using nanopore technology for societal health,environmental,and energy challenges

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第11期15卷 9906-9920页

作者： Izadora Mayumi Fujinami Tanimoto Benjamin Cressiot Sandra J.Greive Bruno Le Pioufle Laurent Bacri Juan Pelta LAMBE CNRSUniv EvryUniversitéParis-Saclay91025Evry-CourcouronnesFrance LuMIn CNRSInstitut d'AlembertENS Paris-SaclayUniversitéParis-Saclay91190Gif-sur-YvetteFrance LAMBE CNRSCY Cergy Paris Université95000CergyFrance DreamPore S.A.S. 33 Boulevard du Port 95000CergyFrance

With an increasing global population that is rapidly ageing,our society faces challenges that impact health,environment,and energy *** this ageing comes an accumulation of cellular changes that lead to the development of diseases and susceptibility to *** impacts not only the health system,but also the global *** the population increases,so does the demand for energy and the emission of pollutants,leading to a progressive degradation of our *** in turn impacts health through reduced access to arable land,clean water,and breathable *** monitoring approaches to assist in environmental control and minimize the impact on health are urgently needed,leading to the development of new sensor technologies that are highly sensitive,rapid,and *** sensing is a new technology that helps to meet this purpose,with the potential to provide rapid point-of-care medical diagnosis,real-time on-site pollutant monitoring systems to manage environmental health,as well as integrated sensors to increase the efficiency and storage capacity of renewable energy *** this review we discuss how the powerful approach of nanopore based single-molecule,or particle,electrical promises to overcome existing and emerging societal challenges,providing new opportunities and tools for personalized medicine,localized environmental monitoring,and improved energy production and storage systems.

关键词： electric sensor nanoparticles environment biomarkers energy storage

Electrochemical reactivity of In-Pb solid solution as a negative electrode for rechargeable Mg-ion batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第4期30卷 124-128页

作者： Lucie Blondeau Suzy Surble Eddy Foy Hicham Khodja Magali Gauthier universitéparis-saclay CEACNRSNIMBELEEL91191Gif-sur-YvetteFrance universitéparis-saclay CEACNRSNIMBELAPA-IRAMAT91191Gif-sur-YvetteFrance

A composite In-Pb:carbon was successfully synthetized by a two-step mechanochemical synthesis in order to obtain an adequate particles size and structure to investigate the electrochemical reactivity of the In-Pb solid solution towards Mg.A potential synergetic coupling of electroactive elements In and Pb was examined using electrochemical and ex situ X-ray diffraction *** potential profile of the solid solution indicates the formation of Mg_(2)Pb and Mg ***,the diffraction study suggests a peculiar electrochemically-driven amorphization of Mg In during the magnesiation,in strong contrast to Mg In crystallization in In-based and In Bi-based electrodes reported in the *** In and Pb favors the amorphization of Mg In and a high first magnesiation capacity of about 550 m Ah g^(-1),but is thereafter detrimental to the material’s *** results emphasize the possible influence of electrochemically-driven amorphization and crystallization processes on electrochemical performance of battery materials.

关键词： Magnesium battery Negative electrode Alloy Amorphization

Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2018年第3期8卷 420-431页

作者： Elisabetta Pancani Mario Menendez-Miranda Alexandra Pastor Francois Brisset Marie-Francoise Bernet-Camard Didier Desmaele Ruxandra Gref Institut de Sciences Moléculaires d'Orsay(ISMO) Univ.of Paris-SudUniversitéParis-Saclay Institut Galien UMR8612 Univ.of Paris-SudUniversitéParis-Saclay Institut de Chimie Moléculaire et des Matériaux d'Orsay(ICMMO) Univ.of Paris-SudUniversitéParis-Saclay EA4043" UnitéBactéries Pathogènes et Santé"(UBaPS) Univ.of Paris-SudUniversitéParis-Saclay

Nowadays, biodegradable polymers such as poly(lactic acid)(PLA), poly(D,L-lactic-coglycolic acid)(PLGA) and poly(ε-caprolactone)(PCL) remain the most common biomaterials to produce drug-loaded nanoparticles(NPs). Pipemidic acid(PIP) is a poorly soluble antibiotic with a strong tendency to crystallize. PIP incorporation in PLA/PLGA NPs was challenging because of PIP crystals formation and burst release. As PIP had a poor affinity for the NPs, an alternative approach to encapsulation was used, consisting in coupling PIP to PCL. Thus, a PCL–PIP conjugate was successfully synthesized by an original drug-initiated polymerization in a single step without the need of ***–PIP was characterized by NMR, IR, SEC and mass spectrometry. PCL–PIP was used to prepare selfassembled NPs with PIP contents as high as 27%(w/w). The NPs were characterized by microscopy,DLS, NTA and TRPS. This study paves the way towards the production of NPs with high antibiotic payloads by drug-initiated polymerization. Further studies will deal with the synthesis of novel polymer–PIP conjugates with ester bonds between the drug and PCL. PIP can be considered as a model drug and the strategy developed here could be extended to other challenging antibiotics or anticancer drugs and employed to efficiently incorporate them in NPs.

关键词： Pipemidic acid Nanoparticle Antibiotic Nanoprecipitation Crystalline drug Drug-initiated polymerization