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Promising effects of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome:a double-blinded randomized controlled trial

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Journal of Traditional Chinese medicine 2025年第1期45卷 100-106页

作者： Neda Naimipoor Zahra Bagheri-Hosseinabadi Mohammad Reza Hajizadeh Mitra Abbasifard Mohammad Reza Mirzaei Akram Ghadiri Anari Maryam Mohammad-Sadeghipour Mehdi Mahmoodi Department of Clinical Biochemistry School of MedicineRafsanjan University of Medical Sciences Department of Internal medicine School of MedicineAli-Ibn Abi-Talib HospitalRafsanjan University of Medical Sciences Molecular medicine Research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical Sciences Diabetes Research Center Shahid Sadoughi University of Medical Sciences Department of Clinical Biochemistry Afzalipour School of MedicineKerman University of Medical Sciences Physiology Research Center Institute of NeuropharmacologyKerman University of Medical Sciences

OBJECTIVE: To evaluate the effect of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome(MetS). METHODS: Fifty patients with Met S diagnosis were randomly assigned to the intervention(Persian shallot extract) and the control(placebo) group. Both groups received treatment for three months. Before the study and at the end of the study, 5 mL peripheral blood was taken from each patient. The measured factors included total antioxidant capacity(TAC), superoxide dismutase enzyme(SOD), malondialdehyde, oxidized low-density lipoprotein(Ox-LDL), apolipoprotein H(Apo-H), fasting blood glucose(FBS), total cholesterol, triglycerides, high-density lipoprotein(HDL), LDL, and systolic and diastolic blood pressure. RESULTS: At baseline, the evaluated parameters were not significantly different between the intervention and control groups. At the end of the study, the mean serum levels of malondialdehyde and ox-LDL were significantly lower in the intervention group. The mean FBS, cholesterol, triglycerides, and LDL were significantly lower in the intervention group. The mean TAC and HDL were significantly higher in the intervention group(P < 0.05). Moreover, the intervention group significantly reduced systolic and diastolic blood pressure. No other significant association was observed. CONCLUSION: Persian shallot extract has several beneficial effects in Met S patients, including optimizing oxidative balance, reducing blood pressure, fasting blood sugar, and blood lipid profile.

关键词： antioxidants medicine, Persian metabolic syndrome shallots

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Exploring Mechanism of Electroacupuncture in Modulating Neuroinflammation Based on Intestinal Flora and Its Metabolites

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Chinese Journal of Integrative medicine 2025年第2期31卷 183-192页

作者： YE Hai-min LI Zhuo-yan ZHANG Peng KANG Zhen ZHOU De-sheng school of Integrated Chinese and Western medicine Hunan University of Chinese MedicineChangsha(410208)China Neurology Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Acupuncture and Moxibustion Massage Rehabilitation Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Neurology Department The First Hospital of Hunan University of Chinese MedicineChangsha(410011)China

Neuroinflammatory responses play an important role in the pathogenesis of various diseases,particularly those affecting the central nervous *** of neuroinflammation is a crucial therapeutic strategy for the management of central nervous system *** intestinal microbial-gut-brain axis serves as a key regulatory pathway that modulates neuroinflammatory *** flora metabolites such as short-chain fatty acids,indoles and their derivatives,lipopolysaccharides,trimethylamine oxide,and secondary bile acids exert direct or indirect effects on *** have shown that electroacupuncture(EA)modulates the composition of the intestinal microbiota and its metabolites,while also suppressing neuroinflammation by targeting the TLR4/NF-κB,NLRP3/caspase-1,and microglial cell M2-type transformation *** review discusses the mechanisms by which EA regulates neuroinflammation via intestinal microbiota and its metabolites,providing information and a foundation for further investigation of the precise therapeutic mechanisms of EA in neurological disorders.

关键词： electroacupuncture intestinal flora metabolites of intestinal flora neuroinflammation nervous system disease review

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A novel BaEVRless-LV packaging system for the production of lentiviral vectors for clinical-grade CAR-NK cell manufacturing

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Cancer Biology & medicine 2025年第02期 137-143页

作者： Yinyin Zhang Minghuan Zhang Mengyuan Li Lihong Zong Qian Ye Wen Lei Wenhai Deng Wenbin Qian Department of Hematology the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Rong Gu Biotechnology Limited Company Biotherapy Research Center the Second Affiliated Hospital Zhejiang University School of Medicine Key Laboratory of Laboratory medicine Ministry of Education School of Laboratory Medicine and Life Sciences Wenzhou Medical University

Chimeric antigen receptor natural killer (CAR-NK) cell therapy is an alternative immunotherapy that provides robust tumor-eliminating effects without inducing life-threatening toxicities and graft-versus-host disease. CAR-NK cell therapy has enabled the development of “off-the-shelf” products that bypass the lengthy and expensive cell manufacturing process1.

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Patients admitted in the intensive care unit after solid organ or bone marrow transplantation:Retrospective cohort study

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World Journal of Transplantation 2025年第1期15卷 95-104页

作者： Ana Vujaklija Brajkovic Iva Kosuta Lucija Batur Sara Sundalic Marijana Medic Andro Vujevic Luka Bielen Jaksa Babel Department of Internal medicine University Hospital Centre ZagrebZagreb 10000Croatia school of medicine University of ZagrebZagreb 10000Croatia

BACKGROUND Solid organ transplantation(SOT)and hematopoietic stem cell transplantation(HSCT)revolutionized the survival and quality of life of patients with malignant diseases,various immunologic,and metabolic disorders or those associated with a significant impairment in a patient's quality of *** To investigate admission causes and treatment outcomes of patients after SOT or HSCT treated in a medical intensive care unit(ICU).METHODS We conducted a single-center,retrospective epidemiological study in the medical ICU at the University Hospital Centre Zagreb,Croatia covering the period from January 1,2018 to December 31,*** The study included 91 patients with either SOT[28 patients(30.8%)]or HSCT[63 patients(69.2%)].The median age was 56(43.2-64.7)years,and 60.4%of the patients were *** with SOT had more comorbidities than patients after HSCT[χ^(2)(5,n=141)=18.513,P<0.001].Sepsis and septic shock were the most frequent reasons for admission,followed by acute respiratory insufficiency in patients following *** rate significantly differed between SOT and HSCT[χ^(2)(1,n=91)=21.767,P<0.001].ICU survival was 57%in the SOT and 12.7%in the HSCT *** need for mechanical ventilation[χ^(2)(1,n=91)=17.081,P<0.001]and vasopressor therapy[χ^(2)(1,n=91)=36.803,P<0.001]was associated with *** necessity for acute renal replacement therapy did not influence patients'survival[χ^(2)(1,n=91)=0.376,P=0.54].In the subgroup of patients with infection,90%had septic shock,and the majority had positive microbiological samples,mostly Gram-negative *** ICU survival of patients with sepsis/septic shock cumulatively was 15%.The survival of SOT patients with sepsis/shock was 45%.CONCLUSION Patients with SOT or HSCT are frequently admitted to the ICU due to sepsis and septic *** advancements in critical care,the mortality rate of patients with refractory septic shock and multiorgan failure in this patient population is extremely hig

关键词： Liver transplantation Kidney transplantation Hematopoietic stem cell transplantation Critical care Sepsis Septic shock Mortality

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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg school of medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

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Immune cells:potential carriers or agents for drug delivery to the central nervous system

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Military Medical Research 2025年第1期12卷 121-153页

作者： Shan-Shan Zhang Ruo-Qi Li Zhong Chen Xiao-Ying Wang Aaron S.Dumont Xiang Fan school of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational medicine of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhou 310053China Clinical Neuroscience Research Center Department of Neurosurgery and NeurologyTulane University School of MedicineNew OrleansLA 70122USA

Drug delivery systems(DDS)have recently emerged as a promising approach for the unique advantages of drug protection and targeted ***,the access of nanoparticles/drugs to the central nervous system(CNS)remains a challenge mainly due to the obstruction from brain *** cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug ***,we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood–brain *** subsequently review biomimetic strategies utilizing immune cell-based nanoparticles for the delivery of nanoparticles/drugs to the CNS,as well as recent progress in rationally engineering immune cell-based DDS for CNS ***,we discuss the challenges and opportunities of immune cell-based DDS in CNS diseases to promote their clinical development.

关键词： Drug delivery systems Immune cells Blood-brain barrier Central nervous system

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Approved delivery strategies for biopharmaceuticals

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Chinese Chemical Letters 2025年第2期36卷 69-79页

作者： Makhloufi Zoulikha Zhongjian Chen Jun Wu Wei He school of Pharmacy China Pharmaceutical University Shanghai Skin Disease Hospital Tongji University School of Medicine Department of Geriatric Cardiology Jiangsu Provincial Key Laboratory of Geriatrics The First Affiliated Hospital of Nanjing Medical University

In recent years, biopharmaceuticals have witnessed remarkable advancements, transforming the landscape of therapeutic interventions. Biopharmaceuticals encompassing therapeutics generated through cutting-edge biotechnological methods have shown promising therapeutic outcomes. However, their clinical success hinges significantly on overcoming drug delivery challenges related to stability, intracellular delivery, immunogenicity, and pharmacokinetic properties. Herein, we provide an overview of various marketed macromolecules, including nucleic acids, and immunotherapeutic agents such as cytokines and monoclonal antibodies, as well as other therapeutic peptides/proteins like enzymes, hormones, and coagulation factors. Our primary focus is on elucidating the delivery challenges associated with these macromolecules and highlighting the pivotal role played by drug delivery platforms in the development of currently marketed products, offering valuable insights for both scientific research and the pharmaceutical industry.

关键词： Biopharmaceuticals Drug delivery Monoclonal antibodies Nucleic acids Proteins

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Chinese medicine for Treatment of COVID-19:A Review of Potential Pharmacological Components and Mechanisms

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Chinese Journal of Integrative medicine 2025年第1期31卷 83-95页

作者： XU Qian-qian YU Dong-dong FAN Xiao-dan CUI He-rong DAI Qian-qian ZHONG Xiao-ying ZHANG Xin-yi ZHAO Chen YOU Liang-zhen SHANG Hong-cai Key Laboratory of Chinese Internal medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China The Geriatrics Center First Affiliated HospitalAnhui University of Chinese MedicineHefei230031China school of Medical Information Engineering Guangzhou University of Chinese MedicineGuangzhou51006China Institute of Basic Research in Clinical medicine China Academy of Chinese Medical SciencesBeijing100700China

Coronavirus disease 2019(COVID-19)is an acute infectious respiratory disease that has been prevalent since December *** medicine(CM)has demonstrated its unique advantages in the fight against COVID-19 in the areas of disease prevention,improvement of clinical symptoms,and control of disease *** review summarized the relevant material components of CM in the treatment of COVID-19 by searching the relevant literature and reports on CM in the treatment of COVID-19 and combining with the physiological and pathological characteristics of the novel *** the basis of sorting out experimental methods in vivo and in vitro,the mechanism of herb action was further clarified in terms of inhibiting virus invasion and replication and improving related *** aim of the article is to explore the strengths and characteristics of CM in the treatment of COVID-19,and to provide a basis for the research and scientific,standardized treatment of COVID-19 with CM.

关键词： Chinese medicine COVID-19 SARS-CoV-2 substance component mechanism experimental method

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SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease

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Science China Life Sciences 2025年

作者： Yichang Shao Qingdian Mu Rong Wang Hongbin Luo Zijun Song Pengfei Wang Jingshu Song Chaodong Ge Jiyan Zhang Junxia Min Fudi Wang The Second Affiliated Hospital The First Affiliated Hospital School of Public Health Institute of Translational Medicine Zhejiang University School of Medicine Institute of Immunology and Department of Rheumatology at Sir Run Run Shaw Hospital Zhejiang University School of Medicine Beijing Institute of Basic Medical Sciences University of South China Hengyang Medical School

Zinc homeostasis plays an essential role in maintaining immune function and is tightly regulated by zinc transporters. We previously reported that the zinc transporter SLC39A10, located in the cell membrane, critically regulates the susceptibility of macrophages to inflammatory stimuli; however, the functional role of SLC39A10 in T cells is currently unknown. Here, we identified two SNPs in SLC39A10that are associated with inflammatory bowel disease(IBD). We then generated transgenic mice with T cell-specific deletion of Slc39a10(cKO) and found that its loss not only protects against disease progression in IBD and experimental autoimmune encephalomyelitis(EAE),but also induces massive apoptosis via a p53/p21-and Bcl2-independent process. Mechanistically, we show that Slc39a10 serves as a key zinc importer upon activation of T cell receptor to safeguard DNA replication. Together, these findings provide new mechanistic insights and potential targets for the development of new therapeutic strategies for the treatment and/or prevention of T cell-mediated autoimmune diseases.

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Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期68卷 35-45页

作者： Xinyu Peng Qian Ma Da Han school of Life Science Shanghai UniversityShanghai 200444China Institute of Molecular medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineState Key Laboratory of Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Research and Development Intellinosis Biotechnologies Co.Ltd.Shanghai 201112China

Gastric cancer(GC)is a prevalent and lethal malignancy worldwide,and the 5-year survival rate is less than 30%.The absence of distinctive symptoms often leads to late-stage diagnosis,contributing to a grim *** detection is pivotal for improving the survival rates and outcomes of GC *** diagnostic methods,including gastroscopy and histopathological examination,are restricted in the early diagnosis of *** protein biomarkers,such as carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9),and carbohydrate antigen 72-4(CA72-4),exhibit insufficient sensitivity and specificity for GC screening,which diminishes their clinical ***,novel circulating biomarkers,such as circulating tumor cells(CTCs),circulating tumor cell DNA(ct DNA),and circulating free RNA(cf RNA),have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and *** review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

关键词： gastric cancer early diagnosis blood

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