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Quantitative Biology 2024年第2期12卷 197-204页

作者： Yahan Li Xinrui Cai Junliang Shang Yuanyuan Zhang Jin-Xing Liu school of Computer Science Qufu Normal UniversityRizhaoChina school of Information and Control Engineering Qingdao University of TechnologyQingdaoChina school of health and life sciences University of Health and Rehabilitation SciencesQingdaoChina

Epistasis is a ubiquitous phenomenon in genetics,and is considered to be one of main factors in current efforts to unveil missing heritability of complex *** data is crucial for evaluating epistasis detection tools in genome-wide association studies(GWAS).Existing simulators normally suffer from two limitations:absence of support for high-order epistasis models containing multiple single nucleotide polymorphisms(SNPs),and inability to generate simulation SNP data *** this study,we proposed a simulator SimHOEPI,which is capable of calculating penetrance tables of high-order epistasis models depending on either prevalence or heritability,and uses a resampling strategy to generate simulation data *** of SimHOEPI are the preservation of realistic minor allele frequencies in sampling data,the accurate calculation and embedding of high-order epistasis models,and acceptable simulation time.A series of experiments were carried out to verify these properties from different *** results show that SimHOEPI can generate simulation SNP data independently with high-order epistasis models,implying that it might be an alternative simulator for GWAS.

关键词： high-order epistasis model penetrance table resampling strategy simulation single nucleotide polymorphisms

The IDD Transcription Factors:Their Functions in Plant Development and Environmental Response

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Phyton-International Journal of Experimental Botany 2024年第1期93卷 63-79页

作者： Jing Liu Defeng Shu Zilong Tan Mei Ma Huanhuan Yang Ning Guo Shipeng Li Dayong Cui school of life sciences Qilu Normal UniversityJinan250200China school of life sciences Shandong Normal UniversityJinan250014China

INDETERMINATE-DOMAIN proteins(IDDs)are a plant-specific transcription factor family characterized by a conserved ID domain with four zinc finger *** studies have demonstrated that IDDs coordinate a diversity of physiological processes and functions in plant growth and development,including floral transition,plant architecture,seed and root development,and hormone *** this review,we especially summarized the latest knowledge on the functions and working models of IDD members in Arabidopsis,rice,and maize,particularly focusing on their role in the regulatory network of biotic and abiotic environmental responses,such as gravity,temperature,water,and *** these mechanisms underlying the function of IDD proteins in these processes is important for improving crop yields by manipulating their ***,the review offers valuable insights into the functions and mechanisms of IDD proteins in plants,providing a foundation for further research and potential applications in agriculture.

关键词： INDETERMINATE DOMAIN flowering time root development shoot gravitropism plant immunity hormonal signaling environmental responses

Tributyltin causes generational neurodevelopmental toxicity and the protective effect of folic acid in zebrafish

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Journal of Environmental sciences 2024年第3期137卷 615-625页

作者： Haoxing Cai Naying Zheng Chen Tang Yuxuan Zhang Zhenghong Zuo Chengyong He State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiang’an Hospital of Xiamen UniversityXiamen UniversityXiamen 361005China

Tributyltin(TBT),a common organotin environmental pollutant,may pose a threat to human development during critical early-life *** aimed to assess the neurodevelopmental intergenerational toxicity of early-life exposure to TBT and the protective effect of DNA methyl donor folic acid(FA).Specifically,after early-life exposure(1–21 days postfertilization,dpf)to TBT(0,1,10 and 100 ng/L),zebrafish(Danio rerio)were cultured in clean medium until sexual *** exposed females were mated with unexposed males to produce embryos(F1).The F1 generation were cultured(4–120 hours post-fertilization,hpf)with and without 1 mmol/L *** neurotoxic effects of early-life TBT exposure for zebrafish and their offspring(F1)were significantly enhanced anxiety and reduced aggression,decreased gene expression of DNA methyltransferase in the brain and increased serotonin levels in the ***,the intergenerational neurodevelopmental toxicity,as manifested in the F1 generation,was attenuated by FA *** summary,early-life TBT exposure led to intergenerational neurodevelopmental deficits in zebrafish,and DNA methyl donors had a protective effect on F1 neurodevelopment,which can inform the prevention and treatment of intergenerational neurotoxicity due to organotin pollutants.

关键词： Tributyltin Neurodevelopment Intergeneration DNA methylation Folic acid Zebrafish

Construction and characterization of a humanized SLCO1B1 rat model with its application in evaluating the uptake of different statins

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1592-1604页

作者： Yuanjin Zhang Junze Huang Shengbo Huang Jie Liu Luyao Deng Chenmeizi Liang Yuanqing Guo Bingyi Yao Xin Wang Changning Maternity and Infant health Hospital and school of life sciences Shanghai Key Laboratory of Regulatory BiologyEast China Normal UniversityShanghai 200241China

Organic anion-transporting polypeptides IB1(OATPIB1)plays a crucial role in the transport of ***,there are too few animal models related to OATPIB1,especially humanized animal *** this study,the human SLCOIB1 cDNA was inserted into the second exon of the rat Slcolb2 gene using CRISPR/Cas9 *** characteristics of statins were conducted in wild-type(WT),humanized OATPIB1(hOATPIB1),and OATPIB2 knockout(OATPIB2 KO)rats,*** results showed that human OATPIB1 was successfully expressed in rat liver and exhibited transport ***,the pharmacokinetic results revealed that OATPIB1 exhibited varying uptake levels of pivastatin,rosuvastatin,and fluvastatin,leading to different levels of exposure within the *** results were consistent with those obtained from in vitro experiments using overexpressed cell *** conclusion,we established a novel humanized SLCOIBI transgenic rat model to assess the role of human OATPIB1 in the uptake of different *** different uptake mediated by OATPIB1 may be an important reason for the different efficacy of *** hOATPIB1 rat is a promising model for improving the prediction of human drug transport.

关键词： CRISPR/Cas9 Drug transport Drug disposition Geneediting Humanized rat model OATP1B1 SLCO1B1 Statins

Immune states:integrated views of immunity by combining traditional Chinese medicine and modern medicine

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Science China(life sciences) 2024年第10期67卷 2271-2273页

作者： Anlong Xu Yuxing Zhi school of life sciences and Qi-Huang school of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China school of life sciences Sun Yat-sen UniversityGuangzhou 510275China

Human immune system is an extraordinarily complex physiological system composed of multiple anatomical systems,diverse tissues and molecules from macroscopic to microscopic *** cells and molecules collectively partici... 详细信息

关键词： immunity homeostasis Immune

Shallow sub-lakes are essential for sustaining the successful wintering of waterbirds in Poyang Lake,China

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Avian Research 2024年第2期15卷 219-228页

作者： Mengjie Lu Zhen Zhang Peng Chen Changxin Xu Bin Gao Luzhang Ruan school of life sciences Nanchang UniversityNanchang330031China Jiangxi Province Key Laboratory of Watershed Ecosystem Change and Biodiversity Center for Watershed EcologyInstitute of Life Science and School of Life SciencesNanchang UniversityNanchang330031China

For migratory waterbirds,the quality of wintering habitat is related to spring migration and successful breeding in the next *** availability of food resources in the habitat is critical and varies within water *** the water-level fluctuations in Poyang Lake have been extremely variable interannually in recent years,the wintering waterbird populations have remained relatively ***,the mechanism of maintaining the stability is worth *** study aimed to compare the distribution of vegetation and herbivorous wa-terbirds in 2015-2016 and 2016-2017,focusing on three shallow sub-lakes and one main lake *** results showed that the emergence of tubers and the growth of Carex *** a continuous food supply and habitat for wintering waterbirds with a gradual decline in the water *** sub-lakes supported almost all of the tuber-eating waterbirds(1.42-1.62×10^(5))and most geese(1.34-1.53×10^(6)).However,the main lake area,covered with Persicaria hydropiper,did not provide adequate and accessible *** resulted in almost no distribution of tuber-eating waterbirds,with only a few geese congregating in early *** results demonstrated that the shallow sub-lakes under human control provided a different environment from the main lake and are key to sustaining the successful wintering of hundreds of thousands of migratory waterbirds in Poyang ***,we recommend refining the anthropogenic management of the shallow sub-lakes to regulate the water level to ensure the carrying capacity of Poyang Lake.

关键词： Anthropogenic management Carrying capacity Seasonal lake Water level Wintering habitat

Sleep-based neuronal oscillations as a physiological biomarker for Alzheimer's disease:is night time the right time?

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Neural Regeneration Research 2024年第7期19卷 1417-1418页

作者： Jonathan Witton Erica S.Brady Michael T.Craig Department of Clinical and Biomedical sciences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Gladstone Institute for Neurological Disease San FranciscoCAUSA school of Psychology and Neuroscience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dementia is a devastating syndrome characterized by memory problems,confusion,and behavior changes that prevent people from performing everyday *** is the leading cause of dependency and disability amongst older people,resulting in a global economic cost of ~$1.3 *** 58 million people are currently afflicted by dementia worldwide,with Alzheimer s disease(AD) causing most(60-70%) of these cases.

关键词： Alzheimer everyday performing

The influence of wing morphology upon intraspecific divergence in birds: A global study of subspecies richness

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Avian Research 2024年第2期15卷 196-201页

作者： Haiying Fan Weibin Guo Buge Lin Zhiqing Hu Changcao Wang Shaobin Li school of life sciences Jinggangshan UniversityJi’An343009China State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhan430062China College of life Science Yangtze UniversityJingzhou434023China

Since the time of Darwin,subspecies have been recognized as an initial stage in the evolution of ***,the impact of dispersal on subspecies richness in birds globally has received little attention,despite dispersal being a key factor in determining the rate of evolution and playing a significant role in evolutionary ***,it is important to conduct a comprehensive study to address this *** this study,we aimed to assess the association between subspecies richness(measured by the number of subspecies)and dispersal ability(measured by the hand-wing index)on a global scale,using a dataset of over 7000 bird *** results revealed a negative correlation between dispersal ability and the number of subspecies,without any quadratic *** wing is a crucial phenotypic trait for birds,and the concept of subspecies is important in speciation theory and conservation ***,our findings not only enhance our understanding of the association between avian morphological traits and evolutionary divergence but also have implications for the conservation of avian species diversity.

关键词： Dispersal Gene flow Hand-wing index Subspecies richness

Implications of mosquito metabolism on vector competence

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Insect Science 2024年第3期31卷 674-682页

作者： Li Gao Wenxu Yang Jingwen Wang State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghaiChina Ministry of Education Key Laboratory of Contemporary Anthropology School of Life SciencesFudan UniversityShanghaiChina

Mosquito-borne diseases(MBDs)annually kill nearly half a million *** to the lack of effective vaccines and drugs on most MBDs,disease prevention relies primarily on controlling *** huge efforts having been put into mosquito control,eco-friendly and sustainable mosquito-control strategies are still lacking and urgently *** mosquito-transmitted pathogens have lost the capacity of de novo nutrition biosynthesis,and rely on their vertebrate and invertebrate hosts for sustenance during the long-term obligate parasitism ***,a better understanding of the metabolic interactions between mosquitoes and pathogens will contribute to the discovery of novel metabolic targets or regulators that lead to reduced mosquito populations or vector *** review summarizes the current knowledge about the effects of mosquito metabolism on the transmission of multiple *** also discuss that research in this area remains to be explored to develop multiple biological prevention and control strategies for MBDs.

关键词： flaviviruses mosquito metabolism Plasmodium vector competence

Immune checkpoint inhibitors:breakthroughs in cancer treatment

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Cancer Biology & Medicine 2024年第6期21卷 451-472页

作者： Xueqing Kong Jinyi Zhang Shuwei Chen Xianyang Wang Qing Xi Han Shen Rongxin Zhang Laboratory of Immunology and Inflammation School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China Department of Biology School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China

Over the past two decades,immunotherapies have increasingly been considered as first-line treatments for most *** such treatment is immune checkpoint blockade(ICB),which has demonstrated promising results against various solid tumors in clinical *** antibodies(mAbs)are currently available as immune checkpoint inhibitors(ICIs).These ICIs target specific immune checkpoints,including cytotoxic T-lymphocyte-associated antigen-4(CTLA-4)and programmed cell death protein 1(PD-1).Clinical trial results strongly support the feasibility of this immunotherapeutic ***,a substantial proportion of patients with cancer develop resistance or tolerance to treatment,owing to tumor immune evasion mechanisms that counteract the host immune ***,substantial research focus has been aimed at identifying additional ICIs or synergistic inhibitory receptors to enhance the effectiveness of anti-PD-1,anti-programmed cell death ligand 1(anti-PD-L1),and anti-CTLA-4 ***,several immune checkpoint molecular targets have been identified,such as T cell immunoreceptor with Ig and ITIM domains(TIGIT),mucin domain containing-3(TIM-3),lymphocyte activation gene-3(LAG-3),V-domain immunoglobulin suppressor of T cell activation(VISTA),B and T lymphocyte attenuator(BTLA),and signal-regulatory proteinα(SIRPα).Functional m Abs targeting these molecules are under ***-4,PD-1/PD-L1,and other recently discovered immune checkpoint proteins with distinct structures are at the forefront of *** review discusses these structures,as well as clinical progress in m Abs targeting these immune checkpoint molecules and their potential applications.

关键词： Immunotherapy cancer ICIs PD-1 CTLA-4