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Mucosal Prolapse of the Urethra in Little Girls about 11 Cases at the urology department of the Sino-Guinean Friendship Hospital in Conakry (Guinea)

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Open Journal of urology 2025年第1期15卷 1-6页

作者： Thierno Amadou Oury Sow Mohamed Habiboullah Ova Thierno Mamadou Oury Diallo Ibrahima Bah Abdoulaye Bobo Diallo Oumar Raphiou Bah department of urology Sino-Guinean Friendship Hospital Faculty of Health Sciences and Technology Gamal Abdel Nasser University of Conakry Conakry Guinea department of urology Amiti Hospital in Nouakchott Nouakchott Mauritania department of urology Ignace Deen National Hospital Faculty of Health Sciences and Technology Gamal Abdel Nasser University of Conakry Conakry Guinea

Introduction: Urethral prolapse, a rare benign lesion of the female urethra, is considered unusual in children, but it is far from exceptional in girls aged 18 to 24. African origin. The diagnosis is clinical but can be overlooked or confused with other pathologies. Treatment remains controversial. The aim of this work is to study the epidemiological, clinical and therapeutic data of urethral mucosal prolapse in young girls in our department. Materials and methods: Retrospective and descriptive study on urethral mucosal prolapse in little girls identified from the hospitalization records of the Sino-Guinean Friendship Hospital in Conakry. The study period was 5 years. Patients were selected randomly. Outcome assessment focused on the occurrence of recurrences and urinary incontinence. The mean follow-up duration was 24 months. The parameters studied were: Age, clinical and histological findings, therapeutic data and patient outcomes. Results: The incidence of urethral mucosal prolapse in girls in the urology department was 2.2 cases/year. The mean age of the patients was 6.7 years (with extremes of 5 months and 10 years). The age group of 7 to 10 years was the most represented, observed in 63.63% of patients. The most frequent reason for consultation was vulvar bleeding in 7 patients, or 63.63%. Malpighian hyperplasia with a congested chorion was the most observed histological type, in 4 patients. Surgical treatment consisting of complete excision of the prolapsed part had given excellent results. Conclusion: Urethral prolapse is a rare pathology, observed mainly in young black girls. Its diagnosis is based mainly on clinical examination. Surgical treatment gives satisfactory results, both clinically and aesthetically.

关键词： Urethral Prolapse Little Girl Squamous Hyperplasia Guinea Conakry

De novo patients with high-volume metastatic hormone-sensitive prostate cancer can benefit from the addition of docetaxel to triplet therapy: Network-analysis and systematic review

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中华医学杂志(英文版) 2025年第2期138卷 2024 Sep 27页

作者： Guo Hanxu Jin Chengqi Ding Li Xie Jun Xu Jing Wang Ruiliang Wang Hong Guo Changcheng Zhang Jiansheng Peng Bo Yao Xudong Yuan Jing Yang Bin department of urology Shanghai Tenth People’s Hospital Tongji University School of Medicine Shanghai China department of urology Urologic Cancer Institute Tongji University School of Medicine Shanghai China department of urology School of Medicine Anhui University of Science and Technology Huainan Anhui China department of urology Shanghai Clinical College Anhui Medical University Shanghai China department of urology Shanghai Tenth People’s Hospital Nanjing Medical University Nanjing Jiangsu China

Epidemiological and Clinical Aspects of Bladder Tumours at the Nianankoro Fomba Hospital in Segou in the urology department

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Open Journal of urology 2022年第5期12卷 294-303页

作者： Sory Ibrahim Kone Honoré Jean Gabriel Berthe Aly Douro Tembely Zanafon Ouattara Mamadou Lamine Diakite urology department Nianankoro Fomba Hospital Ségou Mali department of urology CHU Point G Bamako Mali department of urology CHU Gabriel TOURE Bamako Mali department of urology CHU Gabriel TOURE Bamako Mali

Objectives: To study the epidemiological, diagnostic and prognostic aspects of bladder tumours in Segou Hospital. Patients and Methods: We conducted a descriptive cross-sectional study of bladder tumours over the period from 1 April 2012 to 1 April 2017, in the urology department of the Nianankoro Fomba Hospital in Segou. The first three years were used for patient recruitment, and the last two years for follow-up of the patients in the series. Results: Over a period of three years, we collected 165 cases of bladder tumours hospitalised out of 1308 hospitalisations from 7007 consultations, i.e. 12.6% of hospitalisations and 2.3% of consultations. The sex ratio was 1.2 in favour of men. A history of treated bilharzia was reported in 78.8% of cases and untreated bilharzia in 9.1% of cases. Haematuria was the most common reason for consultation. The majority of our patients were at stage T4 and T3 at the time of diagnosis, i.e. 53.3% and 44.3% respectively. Most patients consulted within 13 to 24 months after the first sign, i.e. 44.8%. Conclusion: The prognosis is still clouded by the delay in management. All the patients diagnosed had a bladder tumour infiltrating the muscle.

关键词： Bladder Tumour Bladder Cancer Epidemiological and Clinical Aspects

Expanding role of antibodies in kidney transplantation

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World Journal of Transplantation 2025年第1期15卷 57-71页

作者： Khawar Abbas Muhammed Mubarak department of Transplant Immunology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan Javed I.Kazi department of Histopathology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan

The role of antibodies in kidney transplant(KT)has evolved significantly over the past few *** role of antibodies in KT is multifaceted,encompassing both the challenges they pose in terms of antibody-mediated rejection(AMR)and the opportunities for improving transplant outcomes through better detection,prevention,and treatment *** our understanding of the immunological mechanisms continues to evolve,so too will the approaches to managing and harnessing the power of antibodies in KT,ultimately leading to improved patient and graft *** narrative review explores the multifaceted roles of antibodies in KT,including their involvement in rejection mechanisms,advancements in desensitization protocols,AMR treatments,and their potential role in monitoring and improving graft survival.

关键词： Antibodies Humoral theory Kidney transplantation Rejection

Effect of kidney transplantation on sexual dysfunction in patients with end stage renal disease:A systematic review

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World Journal of Nephrology 2025年第1期14卷 127-137页

作者： Jaydeep Jain Mahendra Singh Shashank Kumar Om Kumar Yadav Ankit Shettar Shiv Charan Navriya Deepak Prakash Bhirud Gautam Ram Choudhary Arjun Singh Sandhu department of urology All India Institute of Medical SciencesJodhpur 342008RājasthānIndia

BACKGROUND End-stage renal disease(ESRD)is associated with a multitude of physical,psychological,and social health challenges,including a profound impact on sexual and reproductive *** males with ESRD,erectile dysfunction(ED)is highly prevalent due to factors such as underlying comorbidities,including diabetes and hypertension,and the physiological effects of long-term *** transplantation(KTx)has been proposed as a potential intervention to mitigate the effects of ED by restoring renal function and improving hormonal ***,the evidence surrounding the effectiveness of KTx in improving sexual function,specifically erectile function(EF),remains *** systematic review and meta-analysis aim to evaluate the effects of KTx on sexual dysfunction(SexDys),particularly ED,in male ESRD *** To evaluate the benefits and potential harms of KTx compared to other forms of renal replacement therapy in improving EF in adult males with ESRD,assessed using the international index of EF(IIEF),to survey the prevalence of SexDys in this population,and to assess the correlation between various factors and SexDys through regression *** A systematic search of PubMed,EMBASE,Cochrane Library,Scopus,***,and Google Scholar was conducted,following the PRISMA 2020 *** and retrospective cohort studies,as well as cross-sectional studies assessing EF pre-and post-transplantation,were *** studies used validated tools such as the IIEF to measure ***-analyses were performed using a random-effects model to estimate standardized mean differences(SMD)and hazard ratios(HR)with 95%confidence intervals(CI).Heterogeneity was assessed using the I²statistic,and publication bias was evaluated with a funnel plot and the Egger’s *** A total of 2419 studies were identified,with 362 abstracts screened and 193 full-text articles ***,11 studies were included for qualitative analys

关键词： Kidney transplantation Sexual dysfunction Erectile dysfunction International index of erectile function Syste-matic review Meta analyses

Role of variation coefficient of stone density in determining success of shock wave lithotripsy in urinary calculi

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World Journal of Nephrology 2025年第1期14卷 110-118页

作者： Nadeem Iqbal Aisha Hasan Sajid Iqbal Sadaf Noureen Saeed Akhter department of urology and Kidney Transplant Shifa Intl HospitalsIslamabad 44790Pakistan department of urology Pakistan Kidney and Liver InstituteLahore 54000PunjabPakistan department of Biochemistry Riphah International UniversityRawalpindi 44000PunjabPakistan department of Rehabilitation PNS KarachiKarachi 75950SindhPakistan department of Medicine Groves Medical CenterNew MaldenLondon KT33PBUnited Kingdom department urology Shifa International Hospital IslamabadIslamabad 44000Pakistan

BACKGROUND Various stone factors can affect the net results of shock wave lithotripsy(SWL).Recently a new factor called variation coefficient of stone density(VCSD)is being considered to have an impact on stone free *** To assess the role of VCSD in determining success of SWL in urinary *** Charts review was utilized for collection of data *** patients were subjected to SWL,using an electromagnetic *** stone density(MSD),stone heterogeneity index(SHI),and VCSD were calculated by generating regions of interest on computed tomography(CT)*** of these factors were determined by applying the relevant statistical tests for continuous and categorical variables and a P value of<0.05 was gauged to be statistically *** There were a total of 407 patients included in the *** mean age of the subjects in this study was 38.89±14.61 *** total,165 out of the 407 patients could not achieve stone free *** successful group had a significantly lower stone volume as compared to the unsuccessful group(P<0.0001).Skin to stone distance was not dissimilar among the two groups(P=0.47).MSD was significantly lower in the successful group(P<0.0001).SHI and VCSD were both significantly higher in the successful group(P<0.0001).CONCLUSION VCSD,a useful CT based parameter,can be utilized to gauge stone fragility and hence the prediction of SWL outcomes.

关键词： Computed tomography Shock wave lithotripsy Stone heterogeneity Variation coefficient of stone density Kidney stones

TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation

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Oncology Research 2025年第1期33卷 161-169页

作者： XIUWANG WEI JIANBO LIANG HUANWEN HUANG DAMING YANG XINXIN WANG XIUJIA WANG CHANGSHENG CHEN KAIQIANG LI TAISEN PANG BIN HU FENGNING WU department of urology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530000China department of Rehabilitation The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530000China

Background:Transmembrane emp24 trafficking protein 3(TMED3)is associated with the development of several tumors;however,whether TMED3 regulates the progression of prostate cancer remains *** and Methods:Short hairpin RNA was performed to repress TMED3 in prostate cancer cells(DU145 cells)and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in ***:In the present study,we found that TMED3 was highly expressed in prostate cancer *** vitro,shTMED3 treatment suppressed the proliferation,invasion,and migration and promoted the apoptosis of DU145 ***,the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed a strong correlation between TMED3 and forkhead box O transcription factor(FOXO)***,TMED3 inhibition efficiently decreased FOXO1a and FOXO3a *** vivo,TMED3 downregulation suppressed the apoptosis,growth,and metastasis of prostate cancer cells via FOXO1a and ***:The present findings show that TMED3 participates in the regulation of prostate cancer progression via FOXO1a and FOXO3a phosphorylation,thereby revealing a novel mechanism underlying prostate cancer development and suggesting that TMED3 inhibition may serve as a novel strategy for prostate cancer treatment.

关键词： Prostate cancer Transmembrane emp24 trafficking protein 3(TMED3) forkhead box O transcription factor(FOXO) Proliferation Apoptosis

Endoscopic Internal Urethrotomy in the Treatment of Male Urethral Stenosis in the urology-Andrology department of KARA Teaching Hospital (Togo)

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Open Journal of urology 2024年第1期14卷 20-26页

作者： Musapudi Éric Mbuya Komi Hola Sikpa Edoe Viyome Sewa Messan Semefa Agbedey Gnimdou Botcho Kodjo Tengue Tchilabalo Matchonna Kpatcha urology and Andrology department Kara Teaching Hospital Kara Togo urology and Andrology department Hubert Koutoukou Maga National Teaching Hospital Cotonou Benin Surgery department University Clinics of Lubumbashi Lubumbashi DRC Aneho Prefectural Hospital Center Aneho Togo urology and Andrology department Kpalime Prefectural Hospital Center Kpalime Togo urology and Andrology department Sokodé Regional Hospital Center Sokodé Togo urology and Andrology department Sylvanus Olympio Teaching Hospital Lomé Togo

Introduction: Endoscopic internal urethrotomy (EIU) is a method for stricture opening using transurethral incision by direct visualisation of the urethral channel, resulting in a widening of the urinary canal with the aim of improving the quality of bladder emptying. The aim of the study was to evaluate the indication and results of EIU in the treatment of stenosis of the male urethra in the urology-Andrology department of Kara Teaching Hospital. Methodology: This was a cross-sectional descriptive study with retrospective data collection in the urology-Andrology department of Kara Teaching Hospital. It involved 21 records of patients with urethral stenosis treated by endoscopic internal urethrotomy (EIU) in the said department during the period from January 2021 to September 2023. The following variables were evaluated: age, circumstance of discovery, site, length, number, etiology of the urethral stenosis and evolution of the patients. Results: The mean age of the patients was 59.2 ± 11.7 years. Infectious etiology of stenosis was predominant with 10 patients (47.6%) followed by trauma with 5 cases (23.8%). The bulbar urethra was the most frequently observed site, with 11 cases (52.4%). The length was mostly less than 2 cm in 12 patients (57.1%). Stenosis was unique in 14 patients (66.7%). The mean postoperative follow-up time was 3.2 months. The result was immediately better in 11 patients (52.4%) and it was poor in 8 patients (38.1%) who required maintenance dilation sessions.

关键词： Internal Urethrotomy Urethral Stenosis Kara Togo

Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer

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Chinese Chemical Letters 2025年第2期36卷 289-296页

作者： Ze Wang Hao Liang Annan Liu Xingchen Li Lin Guan Lei Li Liang He Andrew K.Whittaker Bai Yang Quan Lin State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University department of Endocrinology Lequn Branch the First Hospital of Jilin University department of urology the First Hospital of Jilin University Australian Institute for Bioengineering and Nanotechnology the University of Queensland

Prostate cancer(PCa) is characterized by high incidence and propensity for easy metastasis, presenting significant challenges in clinical diagnosis and treatment. Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy. Considering that tumor-derived alkaline phosphatase(ALP) is over-expressed in metastatic PCa, it makes a great chance to develop a theranostics system with ALP responsive in the TME. Herein, an ALP-responsive aggregationinduced emission luminogens(AIEgens) nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa. The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence, and enhanced accumulation and prolonged retention period at the tumor site. In terms of detection, the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR) multi-mode imaging effect of nanoprobe was significantly improved post-aggregation, enabling precise diagnosis through the amalgamation of multiple imaging modes. Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis, and enhanced FL imaging technology can achieve “intraoperative visual navigation”, showing its potential application value in clinical tumor detection and surgical guidance. In terms of treatment, AMNF showed strong absorption in the near infrared region after aggregation, which improved the photothermal treatment effect. Overall, our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.

关键词： AIE ALP responsive Enhanced multi-mode imaging Enhanced photothermal therapy Prostate cancer