检索结果-南通市图书馆

ELK3-ID4 axis governs the metastatic features of triple negative breast cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第1期32卷 127-138页

作者： JIN-HO CHOI JOO DONG PARK SEUNG HEE CHOI EUN-SU KO HYE JUNG JANG KYUNG-SOON PARK department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that ELK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the ELK3-ID4 axis regulates the metastatic features of ***:We found that ELK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of E-cadherin in TNBC was regulated by the ELK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in ELK3-knockdown MDA-MB-231(ELK3KD)cells restored the ability to extravasate and ***:The results indicate that the ELK3 regulates ID4 promoter activity,and that the ELK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the ELK3-ID4 axis regulates metastasis of TNBCs by modulating expression of E-cadherin.

关键词： E-cadherin Extravasation Colonization

New approach for particle size and shape analysis of iron-based oxygen carriers at multiple oxidation states

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第7期90卷 493-503页

作者： Victor Purnomo Marcelo Dal Belo Takehara Robin Faust Lidiya Abdisa Ejjeta Henrik Leion Division of Energy and Materials Department of Chemistry and Chemical EngineeringChalmers University of TechnologyGöteborg 41258Sweden Division of Energy Science Department of Engineering Sciences and MathematicsLuleåUniversity of TechnologyLuleå97187Sweden

One of the crucial issues in the chemical looping technology lies in its bed material:the oxygen *** size analysis of an oxygen carrier is important since in a fluidized bed the material can only work well within a specific size *** the favorable size ranges for oxygen carrier materials have already been reported,none of the published studies has analyzed the particle size and shape of oxygen carriers in ***,the effect of oxygen carriers'oxidation degree on such properties has not been considered *** study aimed to report the particle size and shape analysis of five iron-based oxygen carriers,one natural ore,one synthetic material,and three residue products,at different oxidation degrees using dynamic image analysis(DIA).The oxygen carriers were prepared at different mass conversion degrees in a fluidized bed batch *** size distribution,sphericity,and aspect ratio of the oxygen carrier particles were examined experimentally using a Camsizer *** results show that the DIA method was successfully able to analyze the particle size and shape of our oxygen carriers with satisfying accuracy for *** oxidation state of the investigated materials seems to only affect the particle size and shape of oxygen carriers to a minor ***,exposures to redox cycles in a fluidized bed reactor may alter the particle size and shape of most oxygen carriers.

关键词： Oxygen carrier Size and shape analysis Dynamic image analysis Oxidation state Fluidized bed Chemical looping

Financial and non-financial determinants of the indebtedness of hospitals:the case of Poland

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Management Analytics 2024年第1期11卷 26-44页

作者： Katarzyna Miszczyńska Elżbieta Antczak department of Banking Faculty of Economics and SociologyUniversity of LodzLodzPoland department of Spatial Econometrics Faculty of Economics and SociologyUniversity of LodzLodzPoland

The performance of Polish healthcare is still far from satisfactory,which is connected with growing indebtedness that adversely affects not only the development of healthcare but also the quality of medical services *** turn,the financial situation of hospitals depends on various indicators and the relationship between *** paper investigates the determinants of healthcare sector functioning in the context of hospitals’financial situation(dependent variable measured by total debt ratio).321 individual public units were examined between years 2007–*** specifically,the fixed effects panel data model in question measures and evaluates the impact of economic,regional,institutional,and social factors in determining the dependent *** study confirmed dependencies between financial and non-financial ratios along with their impact on the financial condition of studied *** management implications of our study lay the groundwork for the improvement of efficient resource management for public hospitals.

关键词： polish healthcare system hospitals’financial situation debt ratio panel data analysis

Managing the surge:A comprehensive review of the entire disposal framework for retired lithium-ion batteries from electric vehicles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第5期92卷 648-680页

作者： Ruohan Guo Feng Wang M.Akbar Rhamdhani Yiming Xu Weixiang Shen department of Engineering Technologies School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia department of Chemistry and Biotechnology School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia department Mechanical and Product Design Engineering School of EngineeringSwinburne University of TechnologyMelbourne VIC 3122Australia

Anticipating the imminent surge of retired lithium-ion batteries(R-LIBs)from electric vehicles,the need for safe,cost-effective and environmentally friendly disposal technologies has *** paper seeks to offer a comprehensive overview of the entire disposal framework for R-LIBs,encompassing a broad spectrum of activities,including screening,repurposing and ***,we delve deeply into a thorough examination of current screening technologies,shifting the focus from a mere enumeration of screening methods to the exploration of the strategies for enhancing screening ***,we outline battery repurposing with associated key factors,summarizing stationary applications and sizing methods for R-LIBs in their second life.A particular light is shed on available reconditioning solutions,demonstrating their great potential in facilitating battery safety and lifetime in repurposing scenarios and identifying their techno-economic *** the realm of battery recycling,we present an extensive survey of pre-treatment options and subsequent material recovery ***,we introduce several global leading recyclers to illustrate their industrial processes and technical ***,relevant challenges and evolving trends are investigated in pursuit of a sustainable end-of-life management and disposal *** hope that this study can serve as a valuable resource for researchers,industry professionals and policymakers in this field,ultimately facilitating the adoption of proper disposal practices.

关键词： Lithium-ion battery Battery reproposing and recycling Miaieiials recovery technologies Techno-economic issues End-of-life management Disposal framework

Analysis of Heat Transport in a Powell-Eyring Fluid with Radiation and Joule Heating Effects via a Similarity Transformation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2023年第3期19卷 663-677页

作者： Tahir Naseem Iqra Bibi Azeem Shahzad Mohammad Munir department of Mathematics Government Postgraduate College Haripur22620Pakistan Basic Sciences department University of Engineering and TechnologyTaxila47050Pakistan department of Mathematics Government Postgraduate CollegeAbbottabad22010Pakistan

Heat transfer in an Eyring-Powell fluid that conducts electricity and flows past an exponentially growing sheet is *** the sheet is stretched in the x direction,the flow develops in the region with y>*** problem is tackled through a set of partial differential equations accounting for Magnetohydrodynamics(MHD),radiation and Joule heating effects,which are converted into a set of equivalent ordinary differential equations through a similarity *** converted problem is solved in MATLAB in the framework a fourth order accurate integration *** is found that the thermal relaxation period is inversely proportional to the thickness of the thermal boundary layer,whereas the Eckert-number displays the opposite *** this characteristic number grows,the temperature within the channel increases.

关键词： Stretched flow powell-eyring model heat flux model radiated effect relaxation phenomenon numerical study

The Effect of Core Eccentricity on the Structural Behavior of Concrete Tall Buildings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Civil Engineering and Architecture 2024年第3期18卷 112-117页

作者： Tarek Anwar Taha Awida Civil and Architecture Engineering department College of EngineeringInternational University of Kuwait(IUK)Ardiya Government AreaKuwait

The main purpose of this paper is to investigate the effect of core eccentricity on the structural behavior of concrete tall *** buildings of 55 floors with plan dimensions 48.0×48.0 m2 were *** cases of main core locations are studied:centric(A),eccentric by one sixth(B)and one third(C)of building *** three-dimensional finite element method has been used in conducting structural analysis through ETABS *** and lateral(wind and seismic)loadings are applied to all building *** has been concluded that the core location is the prime parameter governing the structural behavior of tall *** the first two cases(A,B)have acceptable and similar structural behaviors conforming to code limits,in the third case(C),the building behavior came beyond code *** author introduced remedial action by adding two secondary cores in the opposite direction of the main core(C-R)to restore the building behavior to the code *** results of this action were satisfactory.

关键词： Concrete tall buildings core eccentricity structural behavior gravity wind seismic loadings

Prediction of Damping Capacity Demand in Seismic Base Isolators via Machine Learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第3期138卷 2899-2924页

作者： Ayla Ocak Umit Isıkdag Gebrail Bekdas Sinan Melih Nigdeli Sanghun Kim ZongWoo Geem department of Civil Engineering Istanbul University-CerrahpasaIstanbul34320Turkey department of Informatics Mimar Sinan Fine Arts UniversityIstanbul34427Turkey department of Civil and Environmental Engineering Temple UniversityPhiladelphiaPA19122USA department of Smart City Gachon UniversitySeongnam13120Korea

Base isolators used in buildings provide both a good acceleration reduction and structural vibration control *** base isolators may lose their damping capacity over time due to environmental or dynamic *** deterioration of them requires the determination of the maintenance and repair needs and is important for the long-termisolator *** this study,an artificial intelligence prediction model has been developed to determine the damage and maintenance-repair requirements of isolators as a result of environmental effects and dynamic factors over *** the developed model,the required damping capacity of the isolator structure was estimated and compared with the previously placed isolator capacity,and the decrease in the damping property was tried to be *** this purpose,a data set was created by collecting the behavior of structures with single degrees of freedom(SDOF),different stiffness,damping ratio and natural period isolated from the foundation under far fault *** data is divided into 5 different damping classes varying between 10%and 50%.Machine learning model was trained in damping classes with the data on the structure’s response to random seismic *** a result of the isolator behavior under randomly selected earthquakes,the recorded motion and structural acceleration of the structure against any seismic vibration were examined,and the decrease in the damping capacity was estimated on a class *** performance loss of the isolators,which are separated according to their damping properties,has been tried to be determined,and the reductions in the amounts to be taken into account have been determined by *** the developed prediction model,using various supervised machine learning classification algorithms,the classification algorithm providing the highest precision for the model has been *** the results are examined,it has been determined that the damping of the isolator structure with the

关键词： Vibration control base isolation machine learning damping capacity

Dual-logic-in-memory implementation with orthogonal polarization of van der Waals ferroelectric heterostructure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

InfoMat 2024年第2期6卷 107-117页

作者： Jingjie Niu Sumin Jeon Donggyu Kim Sungpyo Baek Hyun Ho Yoo Jie Li Ji-Sang Park Yoonmyung Lee Sungjoo Lee SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea department of Nano Science and Technology Sungkyunkwan UniversitySuwonRepublic of Korea department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea IMEC HeverleeBelgium department of Nano Engineering Sungkyunkwan UniversitySuwonRepublic of Korea

The rapid advancement of AI-enabled applications has resulted in an increasing need for energy-efficient computing ***-in-memory is a promising approach for processing the data stored in memory,wherein fast and efficient computations are possible owing to the parallel execution of reconfigurable logic *** this study,a dual-logic-in-memory device,which can simultaneously perform two logic operations in four states,is demonstrated using van der Waals ferroelectric field-effect transistors(vdW FeFETs).The proposed dual-logic-in-memory device,which also acts as a twobit storage device,is a single bidirectional polarization-integrated ferroelectric field-effect transistor(BPI-FeFET).It is fabricated by integrating an in-plane vdW ferroelectric semiconductor SnS and an out-of-plane vdW ferroelectric gate dielectric material—CuInP_(2)S_(6).Four reliable resistance states with excellent endurance and retention characteristics were *** two-bit storage mechanism in a BPI-FeFET was analyzed from two perspectives:carrier density and carrier injection controls,which originated from the out-of-plane polarization of the gate dielectric and in-plane polarization of the semiconductor,*** conventional multilevel FeFETs,the proposed BPIFeFET does not require additional pre-examination or erasing steps to switch from/to an intermediate polarization,enabling direct switching between the four memory *** utilize the fabricated BPI-FeFET as a dual-logic-inmemory device,two logical operations were selected(XOR and AND),and their parallel execution was *** types of logic operations could be implemented by selecting different initial states,demonstrating various types of functions required for numerous neural network *** flexibility and efficiency of the proposed dual-logic-in-memory device appear promising in the realization of next-generation low-power computing systems.

关键词： ferroelectric field-effect transistor in-plane ferroelectricity logic-in-memory out-of-plane ferroelectricity

Flow and Melting Thermal Transfer Enhancement Analysis of Alumina,Titanium Oxide-Based Maxwell Nanofluid Flow Inside Double Rotating Disks with Finite-Element Simulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2022年第3期130卷 1771-1788页

作者： Liangliang Chen Madeeha Tahir Sumeira Yasmin Taseer Muhammad Muhammad Imran Fenghua Liu ChongqingWater Resources and Electric Engineering Collage Chongqing402160China department of Mathematics Government College Women UniversityFaisalabad38000Pakistan department of Mathematics Government College University FaisalabadLayyah CampusLayyah31200Pakistan department of Mathematics College of SciencesKing Khalid UniversityAbha61413Saudi Arabia department of Mathematics Government College UniversityFaisalabad38000Pakistan

The energy produced by the melting stretching disks surface has a wide range of commercial applications,including semi-conductor material preparation,magma solidification,permafrost melting,and frozen land refreezing,among *** view of this,in the current communication we analyzed magnetohydrodynamic flow ofMaxwell nanofluid between two parallel rotating *** are important due to their astonishing properties in heat conduction flows and in the enhancement of electronic and manufacturing ***,the distinct tinysized particles Al_(2)O_(3)and TiO_(2)in theMaxwell water-based fluid for enhancing the heat transfer rate are *** heat equation is developed in the occurrence of thermal *** influences of melting impacts are *** mathematical model is developed in the form of partial differential expressions then converted to ordinary differential equations by employing tool of similarity *** element method(FEM)is chosen for solving the nonlinear governing ordinary differential equations(ODEs)with necessary *** consequence of flow parameters against the velocity profiles and heat transport field is *** noted novelty of this communication is to discuss the thermal transfer of Maxwell nanofluid model through double stretching disks with thermal radiation and melting ***,Al_(2)O_(3)/water and TiO_(2)/water are considered in the modeling.

关键词： Maxwell nanofluid melting phenomenon thermal radiation revolving stretching disks finite element method(FEM)