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Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

Food Science and Human Wellness 2024年第4期13卷 1886-1905页

作者： Wei Li Haihong Chen Hongliang Chen Ziyin Li Wei Hu Qinxuan Zhou Bing Xu Yi Wang Xinhui Xing Institute of Biopharmaceutical and Health engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and engineering Shenzhen Bay LaboratoryShenzhen 440300China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Affiliated Dongguan Hospital Southern Medical University(Dongguan People’s Hospital)Dongguan 523059China

Hyperuricemia(HUA)is a vital risk factor for chronic kidney diseases(CKD)and development of functional foods capable of protecting CKD is of *** paper aimed to explore the amelioration effects and mechanism of Andrias davidianus bone peptides(ADBP)on HUA-induced kidney *** the present study,we generated the standard ADBP which contained high hydrophobic amino acid and low molecular peptide *** vitro results found that ADBP protected uric acid(UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant *** vivo results indicated that ADBP effectively ameliorated renal injury in HUA-induced CKD mice,evidenced by a remarkable decrease in serum UA,creatinine and blood urea nitrogen,improving kidney UA excretion,antioxidant defense and histological kidney *** analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney ***,ADBP restored the gut microbiome homeostasis in CKD mice,especially with respect to the elevated helpful microbial abundance,and the decreased harmful bacterial *** study demonstrated that ADBP displayed great nephroprotective effects,and has great promise as a food or functional food ingredient for the prevention and treatment of HUA-induced CKD.

关键词： Andrias davidianus bone peptides Hyperuricemia Uric acid Chronic kidney disease Gut microbiota

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Multi-agent mobile networking observation experiment at the air-sea interface of ocean eddy

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Science China Earth Sciences 2024年第10期67卷 3083-3097页

作者： Yi ZHANG Dongxiao WANG Li ZHOU Chunhua QIU Yunfei ZHANG Zhiliang DENG Biao ZHANG Yunping LIU Yeqiang SHU Fenghua ZHOU Danian LIU Zhengqiu ZHANG School of Marine Sciences Sun Yat-Sen University Southern Marine Science and engineering Guangdong Laboratory (Zhuhai) School of Marine Technology and Geomatics Jiangsu Ocean University Zhuhai Yunzhou Intelligent Technology Co. Ltd.Research and Design Center School of Automation Nanjing University of Information Science & Technology School of Marine Sciences Nanjing University of Information Science & Technology State Key Laboratory of Tropical Oceanography South China Sea Institute of Oceanology Chinese Academy of Sciences

Current climate forecasting has advanced to the stage of investigating mesoscale air-sea interactions. Recent studies have identified significant structural differences between the cores and edges of mesoscale eddies; however, the effects of these structural variations on air-sea fluxes and the Marine Atmospheric Boundary Layer(MABL) remain underexplored. Traditional observations often fail to capture the detailed structures of eddies, necessitating enhanced observations at high spatiotemporal resolution for mesoscale eddies. To address this, efforts have been made to develop multi-agent platforms and expendable air-sea interface observation technologies. A task-oriented observation scheme was developed to monitor the spatial characteristics of mesoscale eddies. The South China Sea(SCS) is rich in mesoscale eddies with rapid motion changes, requiring enhanced observations of the air-sea interface using multi-agent mobile networking. An anticyclonic eddy was observed in the eastern region of the Xisha Islands in the SCS, and we examined variations in air-sea fluxes across different regions within the eddy.

关键词： Multi-agent Mobile networking Mesoscale eddy Air-sea interface Collaborative observation

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Simultaneous acceleration of sulfur reduction and oxidation on bifunctional electrocatalytic electrodes for quasi-solid-state Zn–S batteries

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Science China Chemistry 2024年第5期67卷 1531-1538页

作者： Mingli Wang Hong Zhang Tianhang Ding Fangjun Wu Lin Fu Bin Song Pengfei Cao Ke Lu Institutes of Physical Science and information Technology School of Materials Science and EngineeringKey Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationAnhui UniversityHefei 230601China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China School of Chemistry and Chemical engineering Harbin Institute of TechnologyHarbin 150001China School of Chemistry and Chemical engineering Guizhou UniversityGuiyang 550025China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China State Key Lab of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

The incomplete sulfur reduction and high ZnS re-oxidation energy barrier along with severe side reactions during the battery cycling compromise the practical application of Zn–S electrochemistry. Herein, a bifunctional electrocatalytic sulfur matrix that simultaneously accelerates the sulfur reduction and ZnS oxidation is proposed to realize a highly-efficient Zn–S cell. It is revealed that the N-heteroatom hotspots are more favorable for facilitating the conversion of S to ZnS while the CoO nanocrystal substantially lowers the ZnS activation energy barrier thereby suppressing the formation of disproportionation species(e.g.,SO_(4)^(2-)) and accumulation of inactive ZnS. Accordingly, the Co O anchored on the N-doped carbon-supported sulfur cathode delivers a high Zn^(2+)storage capacity of 1,172 m Ahg^(-1)and outstanding cycling stability with a capacity retention of 71.6% after500 cycles with a high average Coulombic efficiency of 97.8%. Simultaneously, the stable cycling of solid-state Zn–S pouch cells with an energy density of 585 Whkg^(-1)sulfuris also demonstrated. Moreover, the postmortem analysis reveals that the degradation of Zn–S cells is mainly attributed to the limited reversibility of Zn anodes rather than the ZnS decomposition and/or accumulation. The approach to the bidirectional catalysis manipulated the sulfur redox provides a new perspective to realize the theoretical potentials of Zn–S cells.

关键词： Zn–S battery bifunctional catalysts solid-state battery sulfur redox degradation mechanism

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Natural Disaster Risk Monitoring for Immovable Cultural Relics Based on Digital Twin

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Journal of Geodesy and Geoinformation Science 2024年第1期7卷 90-104页

作者： LI Bolun DONG Youqiang QIAO Yunfei HOU Miaole WEN Caihuan The International Joint Laboratory of Safety and Energy Conservation for Ancient Buildings Beijing University of Civil Engineering and ArchitectureBeijing 102616China China Cultural Heritage information and Consulting Center Beijing 100029China Hebei Institute of Geological Surveying and Mapping Langfang 065000China

Natural disaster risk monitoring is an important task for disaster prevention and *** the case of immovable cultural relics,however,the feedback mechanism,risk factors,monitoring logic,and monitoring indicators of natural disaster risk monitoring are *** to achieve intelligent perception and monitoring of natural disaster risk for immovable cultural relics has always been a focus and a challenge for *** on the analysis of the concepts and issues related to the natural disaster risk of immovable cultural relics,this paper proposes a framework for natural disaster risk monitoring for immovable cultural relics based on the digital *** framework focuses on risk monitoring,including the physical entities of natural disaster risk for immovable cultural relics,monitoring indicators,and virtual entity construction.A platform for monitoring the natural disaster risk of immovable cultural relics is *** the Puzhou Ancient City Site as a test bed,the proposed concept can be used for monitoring the natural disaster risk of immovable cultural relics at different scales.

关键词： immovable cultural relics natural disaster risk digital twin risk monitoring

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Recent Advances in Catalytic Carbonylation Reactions in Alternative Reaction Media

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Chinese Journal of Chemistry 2024年第4期42卷 406-429页

作者： Csaba Árvai László T.Mika department of Chemical and Environmental Process engineering Faculty of Chemical Technology and BiotechnologyBudapest University of Technology and EconomicsMűegyetem rkp.3H-1111 BudapestHungary

Since the discovery of the hydroformylation(oxo-synthesis or Roelen reaction)and the Reppe-reaction,the transition metal-catalyzed carbonylation reactions,providing versatile,facile,and even atom-economic methods for the selective incorporation of C=O functionality to various skeletons,have gained tremendous importance in synthetic organic chemistry from laboratories to industrial *** carbonylation of carbon-carbon multiple bonds,aromatic halides,triflates,etc.,in the presence of various nucleophiles has led the way to produce aldehydes,carboxylic acids,esters,amides,etc.,in the fine chemical ***,these protocols usually proceed in conventional,fossil-based,and usually toxic reaction ***,several attempts have been directed to developing efficient carbonylation methods in alternative,less harmful,non-fossil-based and even in renewable reaction *** this review,we overview the recent applications of alternative solvents such as water,biomass-based alcohols,γ-valerolactone(GVL),2-methyltetrahydrofuran(2-MeTHF),ionic liquids(ILs),deep eutectic solvents(DES),alkyl levulinates,limonene,α-pinene,and dimethyl carbonate as well as fluorous media to improve efficiency,safety and environmentally benign nature of carbonylation protocols.

关键词： Carbonylation Catalysis Solvents Green chemistry Carbon monoxide Transition metals Homogeneous catalysis Palladium

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Shock effects on the upper limit of the collision weld process window

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Advances in Manufacturing 2024年第2期12卷 365-378页

作者： Blake Barnett Anupam Vivek Glenn Daehn department of Materials Science and engineering The Ohio State UniversityColumbusOH43210USA Army Research Directorate Army Research LaboratoryDEVCOMAberdeen Proving GroundHarfordMD21005USA

The maximum flyer impact velocity based on a dynamic solidification cracking mechanism is proposed to describe the upper limit of collision welding process ***,the upper limit of the weld window is governed by the evolution of dynamic stresses and temperatures at the weld *** formulations for the upper limit of the collision weld window assume that both the flyer and target are made of the same material and approximate stress propagation velocities using the acoustic velocity or the shear wave velocity of the weld ***,collision welding fundamentally depends on the impacts that generate shockwaves in weld members,which can dominate the stress propagation velocities in thin weld ***,this study proposes an alternative weld window upper limit that approximates stress propagation using shock velocities calculated from modified 1-D Rankine-Hugoniot *** shock upper limit is validated against the experimental and simulation data in the collision welding literature,and offers a design tool to rapidly predict more accurate optimal collision weld process limits for similar and dissimilar weld couples compared to existing models without the cost or complexity of high-fidelity simulations.

关键词： Collision welding Solid-state welding Shock impact Weld process modelling Explosive bonding Laser impulse welding(LIW)

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Modeling Long- and Short-Term Service Recommendations with a Deep Multi-Interest Network for Edge Computing

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Tsinghua Science and Technology 2024年第1期29卷 86-98页

作者： Rui Yuan Shunmei Meng Ruihan Dou Xinna Wang department of Computer Science and engineering Nanjing University of Science and TechnologyNanjing 210056China Faculty of Mathematics University of WaterlooWaterloo N2L 3G1Canada

Edge computing platforms enable application developers and content providers to provide context-aware services(such as service recommendations)using real-time wireless access network *** to recommend the most suitable candidate from these numerous available services is an urgent ***-through rate(CTR)prediction is a core task of traditional service ***,many existing service recommender systems do not exploit user mobility for prediction,particularly in an edge computing *** this paper,we propose a model named long and short-term user preferences modeling with a multi-interest network based on user *** uses a logarithmic network to capture multiple interests in different fields,enriching the representations of user short-term *** terms of long-term preferences,users'comprehensive preferences are extracted in different periods and are fused using a nonlocal *** experiments on three datasets demonstrate that our model relying on user mobility can substantially improve the accuracy of service recommendation in edge computing compared with the state-of-the-art models.

关键词： recommender system logarithmic network nonlocal network

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Evaluating and Addressing Interoperability Constraints in Health information Systems for Enhanced Healthcare Delivery in Zimbabwe

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Journal of Computer and Communications 2024年第7期12卷 133-154页

作者： Prosper Tafadzwa Denhere Nelson Matanana Munyaradzi Zhou Caleb Manjeese Talent Mawere department of Marketing and information Sciences Midlands State University Gweru Zimbabwe department of Computer Science and information Systems Manicaland State University of Applied Sciences Mutare Zimbabwe department of Mathematics and Computer Science Great Zimbabwe University Masvingo Zimbabwe

Interoperability constraints in health information systems pose significant challenges to the seamless exchange and utilization of health data, hindering effective healthcare delivery. This paper aims to evaluate and address these constraints to enhance healthcare delivery. The study examines the current state of interoperability in health information systems, identifies the key constraints, and explores their impact on healthcare outcomes. Various approaches and strategies for addressing interoperability constraints are discussed, including the adoption of standardized data formats, implementation of interoperability frameworks, and establishment of robust data governance mechanisms. Furthermore, the study highlights the importance of stakeholder collaboration, policy development, and technical advancements in achieving enhanced interoperability. The findings emphasize the need for a comprehensive evaluation of interoperability constraints and the implementation of targeted interventions to promote seamless data exchange, improve care coordination, and enhance patient outcomes in healthcare settings.

关键词： Health information System Interoperability Interoperability Constraints

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Bubble dynamics properties of B-particles in a quasi-2D gas-solid fluidized bed:Computational particle fluid dynamics numerical simulation and post-processed by digital image analysis technique

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Particuology 2024年第3期86卷 223-238页

作者： Zemin Yuan Zhong Huang Guotao Qin Guanjia Zhao Suxia Ma Hairui Yang Guangxi Yue Key Laboratory of Clean and Efficient Combustion and Utilization in the Circulating Fluidized Bed Taiyuan University ofTechnologyTaiyuan030024China department of Energy and Power engineering Tsinghua UniversityBeijing100084.China

Bubble dynamics properties play a crucial and significant role in the design and optimization of gas-solid fluidized *** this study,the bubble dynamics properties of four B-particles were investigated in a quasi-two-dimensional(quasi-2D)fluidized bed,including bubble equivalent diameter,bubble size distribution,average bubble density,bubble aspect ratio,bubble hold-up,bed expansion ratio,bubble radial position,and bubble *** studies were performed by computational particle fluid dynamics(CPFD)numerical simulation and post-processed with digital image analysis(DIA)technique,at superficial gas velocities ranging from 2u_(mf) to 7u_(mf).The simulated results shown that the CPFD simulation combining with DIA technique post-processing could be used as a reliable method for simulating bubble dynamics properties in quasi-2D gas-solid fluidized ***,it seemed not desirable for the simulation of bubble motion near the air distributor at higher superficial gas velocity from the simulated average bubble density *** superficial gas velocity significantly affected the bubble equivalent diameter and evolution,while it had little influence on bubble size distribution and bubble aspect ratio distribution for the same *** time-averaged bubble hold-up and bed expansion ratio increased with the increase of superficial gas *** core-annular flow structures could be found in the fluidized bed for all *** average bubble rising velocity increased with the increasing bubble equivalent *** bubble lateral movement,the smaller bubbles might be more susceptible,and superficial gas velocity had a little influence on the absolute lateral velocity of *** simulated results presented a valuable and novel approach for studying bubble dynamics *** comprehensive understanding of bubble dynamics behaviors in quasi-2D gas-solid fluidized beds would provide support in the design,operation,and optimization of gas-solid

关键词： Bubble dynamics properties CPFD simulation Quasi-2D gas-solid fluidized bed Digital image analysis

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Bipartite consensus problems of Lurie multi-agent systems over signed graphs: A contraction approach

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Chinese Physics B 2024年第7期33卷 137-145页

作者：张晓娇吴祥 School of Mathematics and information Science Nanchang Normal UniversityNanchang 330032China School of Mathematical Sciences Guizhou Normal UniversityGuiyang 550001China

This paper examines the bipartite consensus problems for the nonlinear multi-agent systems in Lurie dynamics form with cooperative and competitive communication between different agents. Based on the contraction theory, some new conditions for the nonlinear Lurie multi-agent systems reaching bipartite leaderless consensus and bipartite tracking consensus are presented. Compared with the traditional methods, this approach degrades the dimensions of the conditions, eliminates some restrictions of the system matrix, and extends the range of the nonlinear function. Finally, two numerical examples are provided to illustrate the efficiency of our results.

关键词： contraction theory virtual system bipartite consensus Lurie multi-agent systems

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