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Note on the Lax Pair of a Coupled Hybrid System

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Chinese Physics Letters 2012年第1期29卷 5-7页

作者：刘萍付培凯 Department of Electronic Engineering University of Electronic Science and Technology of China Zhongshan InstituteZhongshan 528402 academic Affairs division Zhongshan PolytechnicZhongshan 528404

The hybrid lattice,known as a discrete Korteweg-de Vries(KdV)equation,is found to be a discrete modified Korteweg-de Vries(mKdV)*** coupled hybrid lattice,which is pointed out to be a discrete coupled KdV system,is also found to be a discrete form of a coupled mKdV *** lax pairs for the single and coupled discrete hybrid systems are proposed as a different study from previous ones.

关键词： equation. lattice coupled

Knowledge, attitudes, and practices regarding Covid-19 and their relationship with Covid-19 booster vaccination status among women with infertility

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Asian pacific Journal of Reproduction 2024年第2期13卷 68-75页

作者： Gita Pratama Mila Maidarti Kanadi Sumapradja Achmad Kemal Harzif Natasha Talya Kevin Ezekia Irfan Arieqal Hatta Ampri Reproductive Immunoendocrinology division Department of Obstetrics and GynecologyFaculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia Yasmin IVF Clinic dr.Cipto Mangunkusumo General Hospital JakartaIndonesia Human Reproduction Infertilityand Family Planning ClusterIndonesia Reproductive Medicine Research and Training CenterFaculty of MedicineUniversitas IndonesiaJakarta 10430Indonesia Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia-dr.Cipto Mangunkusumo General HospitalJakartaIndonesia

Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with ***:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,*** assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic ***:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 *** the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination *** significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding *** participants had poor knowledge about the relationship between infertility and the Covid-19 *** general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.

关键词： Covid-19 Booster vaccine Infertility Knowledge Attitude Practice Human reproduction Pandemic

Functional micro/nanobubbles for ultrasound medicine and visualizable guidance

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Science China Chemistry 2021年第6期64卷 899-914页

作者： Chen Zhang Yihong Li Xinyong Ma Wenxin He Chenxi Liu Zhe Liu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjin 300072China division of academic&Cultural Activities Academic Divisions of the Chinese Academy of SciencesBeijing 100190China

Chemically functionalized gas-filled bubbles with a versatile micro/nano-sized scale have witnessed a long history of developments and emerging applications in disease diagnosis and *** combination with ultrasound and image-guidance,micro/nanobubbles have been endowed with the capabilities of biomedical imaging,drug delivery,gene transfection and diseaseoriented *** an external stimulus,ultrasound(US)-mediated targeting treatments have been achieving unprecedented ***,US is playing a crucial role in visualizing biological/pathological changes in lives as a reliable imaging technique and a powerful therapeutic *** review retrospects the history of ultrasound,the chemistry of functionalized agents and summarizes recent advancements of functional micro/nanobubbles as US contrast agents in preclinical and transclinical *** ultrasound-based treatment modalities in association with functional micro/nanobubbles have been highlighted as their great potentials for disease precision *** is believed that these state-of-the-art micro/nanobubbles will become a booster for ultrasound medicine and visualizable guidance to serve future human healthcare in a more comprehensive and practical manner.

关键词： ultrasound functional biomaterials image guidance visualizable medicine drug delivery

A snapshot into the future of image-guided surgery for renal cancer

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Asian Journal of Urology 2022年第3期9卷 201-203页

作者： Enrico Checcucci Gabriele Volpi Department of Surgery Candiolo Cancer InstituteFPOIRCCSCandioloTurinItaly Department of OncologyDivision of UrologyUniversity of TurinTurinItaly Uro-technology and SoMe Working Group of the Young academic Urologists(YAU)Working Party of the European Association of Urology(EAU) Arnhemthe Netherlands Daniele Amparore Department of Oncology Division of UrologyUniversity of TurinTurinItaly Renal Cancer Working Group of the Young academic Urologists(YAU)Working Party of the European Association of Urology(EAU) Arnhemthe Netherlands Francesco Porpiglia Department of Oncology Division of UrologyUniversity of TurinTurinItaly

Robot-assisted partial nephrectomy(RAPN)is certainly one of the most fascinating and complex urological *** is ascribable to its vast heterogeneity from one case to another,related to patient’s anatomical variability and tumour’s *** the last years,with the aim to assist the surgeons in handling ever more difficult lesions(totally endophytic or large volume[1,2])suitable for RAPN,several technologies were proposed and tested,from preoperative planning to intraoperative assistance or navigation[3].

关键词： image surgery totally

San Antonio witnesses Chinese urological achievements:The World Chinese Urological Society achievement and Rising Star Awards at the 16th annual meeting

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UroPrecision 2024年第2期2卷 65-72页

作者： Guiting Lin Run Wang Tom F.Lue Knuppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCaliforniaUSA Department of Urology Uniersity of Texas MD Anderson Cancer CenterHoustonTexasUSA division of Urology Department of SurgeryUniversity of Texas McGovern Medical SchoolHoustonTexasUSA

San Antonio,May 3,2024—The 16th Annual meeting of the World Chinese Urological Society(WCUS)was successfully held in San Antonio,drawing together experts and scholars from around the globe in the field of Chinese *** conference served as a platform for academic exchange,as well as an occasion for medical professionals of Chinese descent to learn from,inspire,and motivate one *** events are crucial for advancing research and clinical practice in Chinese urology worldwide,and the success of this conference signals a bright and progressive future for the field.

关键词： World exchange witness

JUPITER-02 trial: advancing survival for recurrent metastatic nasopharyngeal carcinoma and next steps

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Cancer Communications 2022年第1期42卷 56-59页

作者： Laura Ling Ying Tan Quynh-Thu Le Nancy Ying Ying Lee Melvin Lee Kiang Chua Ministry of Health Holdings Singapore 099253Singapore Department of Radiation Oncology Stanford UniversityCalifornia 94305USA Department of Radiation Oncology Memorial Sloan Kettering Cancer CenterNew York 10065USA Department of Head and Neck and Thoracic Cancers Division of Radiation Oncology and Division of Medical SciencesNational Cancer Centre SingaporeSingapore 169610Singapore Oncology academic Clinical Programme Duke-NUS Medical SchoolSingapore 169857Singapore

Nasopharyngeal carcinoma(NPC)is a disease with unique *** is endemic in Southern China,Southeast Asia,and North Africa,and typically affects males more than females in the 30-60 years age group[1].Globally,133,354 NPC cases were diagnosed in 2020 with 80,008;deaths in the same year[2].While the survival rates of early-stage NPC after radiotherapy(RT)are high,dis-ease recurrences are common in locoregionally-advanced NPC,with the predominant pattern of failure being dis-tant metastasis[3].In this clinical scenario,palliative chemotherapy is the primary treatment modality。

关键词： epidemiology chemotherapy nasopharyngeal

16th Annual Meeting of the World Chinese Urological Society:Reunion and sharing of global Chinese urological advances

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UroPrecision 2024年第2期2卷 62-64页

作者： Guiting Lin Run Wang Tom F.Lue Knuppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCaliforniaUSA Department of Urology MD Anderson Cancer CenterHoustonTexasUSA Department of Surgery Division of UrologyUniversity of Texas McGovern Medical SchoolHoustonTexasUSA

1|*** few years without in-person meeting during the American Urological Association(AUA)due to COVID-19 pandemic,the world's brightest Chinese urologists and urological researchers gathered *** May 3,2024,the 16th Annual Meeting of the World Chinese Urological Society(WCUS)was successfully held in San Antonio,*** conference attracted Chinese experts and scholars from the field of urology around the world to discuss and share the latest academic achievements and research *** significant event provided an important academic exchange platform for Chinese urology experts globally.

关键词： union globally World

Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago Alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University division of Biosciences Faculty of Life Sciences division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： NADH oxidase H2O2 production oxidative phosphorylation

Hypothesis testing and statistical analysis of microbiome

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Genes & Diseases 2017年第3期4卷 138-148页

作者： Yinglin Xia Jun Sun division of academic Internal Medicine and Geriatrics Department of MedicineUniversity of Illinois at ChicagoChicagoILUSA division of Gastroenterology and Hepatology Department of MedicineUniversity of Illinois at ChicagoChicagoILUSA

After the initiation of Human Microbiome Project in 2008,various biostatistic and bioinformatic tools for data analysis and computational methods have been developed and applied to microbiome *** this review and perspective,we discuss the research and statistical hypotheses in gut microbiome studies,focusing on mechanistic concepts that underlie the complex relationships among host,microbiome,and *** review the current available statistic tools and highlight recent progress of newly developed statistical methods and *** the current challenges and limitations in biostatistic approaches and tools,we discuss the future direction in developing statistical methods and models for the microbiome studies.

关键词： Bioinformatics Biostatistics Cancer Hypothesis testing IBD Microbiome Statistical methods and models Vitamin D receptor