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Altered asymmetries of resting-state MRI in the left thalamus of first-episode schizophrenia

Chronic Diseases and Translational Medicine 2022年第3期8卷 207-217页

作者： Sha Liu Zhenglong Guo Hongbao Cao Hong Li Xiaodong Hu Long Cheng Jianying Li Ruize Liu Yong Xu Deparment of Psychiatry First Hospital/Fist Clinical Medical College of Shanxi Medical UniversityTaiyuanShanxiChina shanxi Key Laboratoryof Arificial Intlligence Disorder First Hospital of Shanxi Medical Assisted Diagnosis and Treatment for Mental UniversityTaiyuanShanxiChina School of Systems Biology .George Mason UniversityManassasVirginiaUSA Stanley Center for Psychiatric Research Broad Institute of MIT and HarvardCambridgeMassachusettsUSA Department of Mental Health Shanxi Medical UniversityTaiyuanShanxiChina

Background:Schizophrenia(SCZ)is a complex psychiatric disorder associated with widespread alterations in the subcortical brain structure.Hemispheric asymmetries are a fundamental organizational principle of the human brain and relate to human psychological and behavioral characteristics.We aimed to explore the state of thalamic lateralization of SCZ.Methods:We used voxel-based morphometry(VBM)analysis,whole-brain analysis of low-frequency fluctuations(ALFF),fractional amplitude of low-frequency fluctuations(fALFF),and resting-state seed-based functional connectivity(FC)analysis to investigate brain structural and functional deficits in SCZ.Also,we applied Pearson’’s correlation analysis to validate the correlation between Positive and Negative Symptom Scale(PANSS)scores and them.Results:Compared with healthy controls,SCZ showed increased gray matter volume(GMV)of the left thalamus(t=2.214,p=0.029),which positively correlated with general psychosis(r=0.423,p=0.010).SCZ also showed increased ALFF in the putamen,the caudate nucleus,the thalamus,fALFF in the nucleus accumbens(NAc),and the caudate nucleus,and decreased fALFF in the precuneus.The left thalamus showed significantly weaker resting-state FC with the amygdala and insula in SCZ.PANSS negative symptom scores were negatively correlated with the resting-state FC between the thalamus and the insula(r=-0.414,p=0.025).Conclusions:Collectively,these results suggest the possibility of aberrant laterality in the left thalamus and its FC with other related brain regions involved in the limbic system.

关键词： asymmetry gray matter volume resting-state fMRI schizophrenia thalamus

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