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circPVT1 promotes silica-induced epithelial-mesenchymal transition by modulating the miR-497-5p/TCF3 axis

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Journal of Biomedical Research 2024年第2期38卷 163-174,I0011-I0015页

作者： Siyun Zhou Yan Li Wenqing Sun Dongyu Ma Yi Liu Demin Cheng Guanru Li Chunhui Ni Department of Occupational Medical and Environmental Health Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Biomedical Publications Center Nanjing Medical UniversityNanjingJiangsu 211166China Gusu school Nanjing Medical UniversityNanjingJiangsu 211166China

Epithelial-mesenchymal transition(EMT)is a vital pathological feature of silica-induced pulmonary ***,whether circRNA is involved in the process remains *** present study aimed to investigate the role of circPVT1 in the silica-induced EMT and the underlying *** found that an elevated expression of circPVT1 promoted EMT and enhanced the migratory capacity of silica-treated epithelial *** isolation of cytoplasmic and nuclear separation assay showed that circPVT1 was predominantly expressed in the *** immunoprecipitation assay and RNA pull-down experiment indicated that cytoplasmic-localized circPVT1 was capable of binding to ***,we found that miR-497-5p attenuated the silica-induced EMT process by targeting transcription factor 3(TCF3),an E-cadherin transcriptional repressor,in the silica-treated epithelial ***,these results reveal a novel role of the circPVT1/miR-497-5p/TCF3 axis in the silica-induced EMT process in lung epithelial *** validated,this finding may provide a potential theoretical basis for the development of interventions and treatments for pulmonary fibrosis.

关键词： silicosis epithelial-mesenchymal transition circPVT1 miR-497-5p TCF3

Uncovering the impact of alcohol on internal organs and reproductive health:Exploring TLR4/NF-kB and CYP2E1/ROS/Nrf2 pathways

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Animal Models and Experimental Medicine 2024年第4期7卷 444-459页

作者： Eason Qi Zheng Kong Vetriselvan Subramaniyan Natasha Sura Anak Lubau Pharmacology Unit Jeffrey Cheah School of Medicine and Health SciencesMonash University MalaysiaSubang JayaSelangorMalaysia Center for global Health Research Saveetha Medical CollegeSaveetha Institute of Medical and Technical SciencesChennaiTamil NaduIndia

This review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health,elucidating the underlying mechanisms involving the Toll-like receptor 4(TLR4)/Nuclear factor kappa light chain enhancer of activated B cells(NF-kB)pathway and the Cytochrome P4502E1(CYP2E1)/reactive oxygen spe-cies(ROS)/nuclear factor erythroid 2-related factor 2(Nrf2)*** TLR4/NF-kB pathway,crucial for inflammatory and immune responses,triggers the production of pro-inflammatory agents and type-1 interferon,disrupting the balance between inflammatory and antioxidant responses when tissues are chronically exposed to ***-induced dysbiosis in gut microbes heightens gut wall permeability to pathogen-associated molecular patterns(PAMPs),leading to liver cell infection and subsequent ***,CYP2E1-mediated alcohol metabolism gen-erates ROS,causing oxidative stress and damaging cells,lipids,proteins,and deoxy-ribonucleic acid(DNA).To counteract this inflammatory imbalance,Nrf2 regulates gene expression,inhibiting inflammatory progression and promoting antioxidant *** alcohol intake results in elevated liver enzymes(ADH,CYP2E1,and catalase),ROS,NADH,acetaldehyde,and acetate,leading to damage in vital organs such as the heart,brain,and ***,alcohol negatively affects reproduc-tive health by inhibiting the hypothalamic-pituitary-gonadal axis,causing infertility in both men and *** findings underscore the profound health concerns associated with alcohol-induced damage,emphasizing the need for public awareness regarding the intricate interplay between immune responses and the multi-organ im-pacts of alcohol consumption.

关键词： alcohol health impact inflammation metabolism molecular pathways

Transforming agri-food systems for multiple wins in nutrition,inclusion and environment

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Journal of integrative Agriculture 2024年第2期23卷 355-358页

作者： Shenggen Fan Qiran Zhao Jingjing Wang Academy of global Food Economics and Policy/College of Economics and Management China Agricultural UniversityBeijing 100083China

The call for agri-food system transformation is urgent in many global development agendas(UN 2023).Food systems have contributed to economic prosperity and feeding the world,but they are also associated with numerous challenges,including climate change,continued hunger,poor diets and malnutrition,and increasing disparities(Webb et al.2020;Fanzo et al.2021).

关键词： continued nutrition urgent

Promoting higher-valent pediatric combination vaccines in China: challenges and recommendations for action

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Infectious Diseases of Poverty 2024年第1期13卷 74-84页

作者： Jiuling Li Shu Chen dwin Asturias Shenglan Tang Fuqiang Cui global Health Research Center Duke Kunshan UniversityKunshanJiangsuChina ARC Centre of Excellence in Population Ageing Research(CEPAR) Universityof New SouthWalesSydneyAustralia school of Risk and Actuarial Studies University of New South WalesSydneyAustralia Department of Pediatrics University of Colorado School of MedicineAuroraCOUSA Center for global Health Colorado School of Public HealthAuroraCOUSA Department of Epidemiology Colorado School of Public HealthAuroraCOUSA Duke global Health Institute Duke UniversityDurhamNCUSA SingHealth Duke-NUS global Health Institute Duke-NUSSingaporeSingapore Department of Laboratorial Science and Technology School of Public HealthPeking UniversityBeijingChina Vaccine Research Center School of Public HealthPeking UniversityBeijingChina

Many countries have adopted higher-valent pediatric combination vaccines to simplify vaccination schedules and minimize health expenditures and social ***,China is conservative in the use of pediatric combina-tion *** reviewing and synthesizing quantitative and qualitative data,in this commentary we identify gaps and challenges to combination vaccine use and make recommendations for promoting use of higher-valent pediatric combination vaccines in *** are in four dimensions:(1)legislation and regulation,(2)immunization schedule design,(3)vaccine awareness and price,and(4)research and development *** optimize the use of combination vaccines to reduce vaccine-preventable disease burden,we make recommendations that address key challenges:(1)develop policies and regulations to strengthen enforcement of the Vaccine Administration Law and remove regulatory hurdles that hinder combination vaccine research and development,(2)establish an evi-dence-informed policy-making mechanism for combination vaccines,(3)resolve immunization schedule conflicts between monovalent and combination vaccines,and(4)implement effective interventions to increase vaccine awareness and reduce price.

关键词： Combination vaccine National immunization program Childhood immunization Vaccine-preventable disease

The Transformation of Economic globalization and China’s Role in It Under Profound Changes Unseen in a Century

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Contemporary World 2024年第3期 8-13页

作者： Chen Jianqi global Governance and International Organization Department Institute of International Strategic StudiesParty School of the Central Committee of the CPC

The world economy prospers when it is open,but declines when it is *** the end of the cold war,economic globalization has developed rapidly,forming a new global development pattern that features intertwined interests of countries all over the *** report to the 20th National Congress of CPC pointed out that at present,changes in the world,times and history are unfolding in a way unseen in the past.

关键词： Transformation globalization pattern

Promoted surface charge density from interlayer Zn–N_(4) configuration in carbon nitride for enhanced CO_(2) photoreduction

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Nano Research 2024年第4期17卷 2400-2409页

作者： Xianjin Shi Yu Huang Gangqiang Zhu Wei Peng Meijuan Chen State Key Laboratory of Loess and Quaternary Geology(SKLLQG) Key Laboratory of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Center of Excellence in Quaternary Science and global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China school of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China school of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049China

The solar-driven reduction of CO_(2) into valuable products is a promising method to alleviate global environmental problems and energy ***,the low surface charge density limits the photocatalytic conversion performance of CO_(2).Herein,a polymeric carbon nitride(PCN)photocatalyst with Zn single atoms(Zn1/CN)was designed and synthesized for CO_(2) *** results of the CO_(2) photoreduction studies show that the CO and CH_(4) yields of Zn1/CN increased fivefold,reaching 76.9 and 22.9μmol/(g·h),respectively,in contrast to the unmodified ***+plasma-etched X-ray photoelectron spectroscopy and synchrotron radiation-based X-ray absorption fine structure results reveal that Zn single atom is mainly present in the interlayer space of PCN in the Zn–N_(4) *** characterizations indicate that the interlayer Zn–N_(4) configuration can amplify light absorption and establish an interlayer charge transfer ***-assisted Kelvin probe force microscopy confirms that more photogenerated electrons are delivered to the catalyst surface through interlayer Zn–N_(4) configuration,which increases its surface charge ***,in-situ infrared spectroscopy combined with density functional theory calculation reveals that promoted surface charge density accelerates key intermediates(*COOH)conversion,thus achieving efficient CO_(2) *** work elucidates the role of internal single atoms in catalytic surface reactions,which provides important implications for the design of single-atom catalysts.

关键词： single-atom catalysts photocatalytic CO_(2)reduction interlayer modification charge transfer dynamics surface charge density

Sustainable all-weather CO2 utilization by mimicking natural photosynthesis in a single material

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National Science Review 2024年第2期11卷 177-187页

作者： Xianjin Shi Yu Huang Ran Long Zhenyu Wang Liqin Wang Junji Cao Gangqiang Zhu Yujie Xiong State Key Laboratory of Loess and Quaternary Geology(SKLLQG) Key Laboratory of Aerosol Chemistry and Physics Institute of Earth EnvironmentChinese Academy of Sciences Center of Excellence in Quaternary Science and global Change Chinese Academy of Sciences University of Chinese Academy of Sciences Hefei National Research Center for Physical Sciences at the Microscale School of Chemistry and Materials Science and National Synchrotron Radiation Laboratory University of Science and Technology of China Institute of Atmospheric Physics Chinese Academy of Sciences school of Physics and Information Technology Shaanxi Normal University

Solar-driven CO2conversion into hydrocarbon fuels is a sustainable approach to synchronously alleviating the energy crisis and achieving net ***,the dependence of the conversion process on solar illumination hinders its practical application due to the intermittent availability of sunlight at night and on cloudy or rainy ***,we report a model material of Pt-loaded hexagonal tungsten trioxide（Pt/h-WO3） for decoupling light and dark reaction processes,demonstrating the sustainable CO2conversion under dark conditions for the first *** such a material system,hydrogen atoms can be produced by photocatalytic water splitting under solar illumination,stored together with electrons in the h-WO3through the transition of W6+to W5+and spontaneously released to trigger catalytic CO2reduction under dark ***,we demonstrate using natural light that CH4production can persist at night and on rainy days,proving the accomplishment of all-weather CO2conversion via a sustainable way.

关键词： sustainable CO2 utilization artificial photosynthesis all-weather application charge storage

Defects evolution in n-type 4H-SiC induced by electron irradiation and annealing

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Journal of Semiconductors 2024年第7期45卷 77-83页

作者： Huifan Xiong Xuesong Lu Xu Gao Yuchao Yan Shuai Liu Lihui Song Deren Yang Xiaodong Pi State Key Laboratory of Silicon and Advanced Semiconductor Materials&school of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Key Laboratory of Power Semiconductor Materials and Devices of Zhejiang Province&Institute of Advanced Semiconductors ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311200China

Radiation damage produced in 4H-SiC by electrons of different doses is presented by using multiple characterization techniques. Raman spectra results indicate that SiC crystal structures are essentially impervious to 10 Me V electron irradiation with doses up to 3000 kGy. However, irradiation indeed leads to the generation of various defects, which are evaluated through photoluminescence(PL) and deep level transient spectroscopy(DLTS). The PL spectra feature a prominent broad band centered at 500 nm, accompanied by several smaller peaks ranging from 660 to 808 nm. The intensity of each PL peak demonstrates a linear correlation with the irradiation dose, indicating a proportional increase in defect concentration during irradiation. The DLTS spectra reveal several thermally unstable and stable defects that exhibit similarities at low irradiation ***, after irradiating at the higher dose of 1000 kGy, a new stable defect labeled as R_(2)(Ec-0.51 eV) appeared after annealing at 800 K. Furthermore, the impact of irradiation-induced defects on SiC junction barrier Schottky diodes is discussed. It is observed that high-dose electron irradiation converts SiC n-epilayers to semi-insulating layers. However, subjecting the samples to a temperature of only 800 K results in a significant reduction in resistance due to the annealing out of unstable defects.

关键词： 4H-SiC deep level transient spectroscopy(DLTS) photoluminescence(PL) defects

Fine classification of rice paddy using multitemporal compact polarimetric SAR C band data based on machine learning methods

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Frontiers of Earth Science 2024年第1期18卷 30-43页

作者： Xianyu GUO Junjun YIN Kun LI Jian YANG Huimin ZOU Fukun YANG school of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China College of global Change and Earth System Science Beijing Normal UniversityBeijing 100875China

Rice is an important food crop for human *** distinguishing different varieties and sowing methods of rice on a large scale can provide more accurate information for rice growth monitoring,yield estimation,and phenological monitoring,which has significance for the development of modern *** polarimetric(CP)synthetic aperture radar(SAR)provides multichannel information and shows great potential for rice monitoring and ***,the use of machine learning methods to build classification models is a controversial *** this paper,the advantages of CP SAR data,the powerful learning ability of machine learning,and the important factors of the rice growth cycle were taken into account to achieve high-precision and fine classification of rice ***,CP SAR data were simulated by using the seven temporal RADARSAT-2 C-band data ***,20-two CP SAR parameters were extracted from each of the seven temporal CP SAR data *** addition,we fully considered the change degree of CP SAR parameters on a time scale(ΔCP_(DoY)).Six machine learning methods were employed to carry out the fine classification of rice *** results show that the classification methods of machine learning based on multitemporal CP SAR data can obtain better results in the fine classification of rice paddies by considering the parameters ofΔCP_(DoY).The overall accuracy is greater than 95.05%,and the Kappa coefficient is greater than *** them,the random forest(RF)and support vector machine(SVM)achieve the best results,with an overall accuracy reaching 97.32%and 97.37%,respectively,and Kappa coefficient values reaching 0.965 and 0.966,*** the two types of rice paddies,the average accuracy of the transplant hybrid(T-H)rice paddy is greater than 90.64%,and the highest accuracy is 95.95%.The average accuracy of direct-sown japonica(D-J)rice paddy is greater than 92.57%,and the highest accuracy is 96.13%.

关键词： compact polarimetric(CP)SAR rice paddy machine learning fine classification multitemporal