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Clinical application and management of temporary mechanical circulatory support: A clinical consensus

中华医学杂志(英文版) 2024年第10期137卷 1135-1139页

作者： Dong Nianguo Chen Liangwan Chen Xin Wang Huishan Xiao Yingbin Wang Xianqiang Huang Jinsong Yan Yang Bonde Pramod Sodha Neel Atluri Pavan Maureira Juan Pablo Vincentelli André Yanase Masanobu Wang Yixuan Zhang Haitao Hou Xiaotong Takami Yoshijuki Leprince Pascal Folliguet Thierry Sellke Frank W Chinese Society for Thoracic and Cardiovascular Surgery Chinese Association of Cardiovascular Surgeons Cardiac Critical Care Professional Committee of Chinese Medical Association Chinese Society of Extracorporeal Life Support European Society of Cardiovascular and Endovascular Surgery French Society of Thoracic and Cardiovascular Surgery Japanese Society for Cardiovascular Surgery Japanese Society of Artificial Organs department of Cardiothoracic Surgery Alpert Medical School Brown University Rhode Island Hospital Providence RI USA department of Cardiovascular Surgery Department of Surgery University of Pennsylvania Philadelphia PA USA department of Cardiovascular Surgery and Transplantation University Hospital of Nancy University of Lorraine Vandoeuvre-lès-Nancy France department of Cardiovascular Surgery University Hospital of Lille University of Lille Lille France department of Cardiology Fujita Health University School of Medicine Toyoake Aichi-1192 Japan department of Adult Surgical Intensive Care Unit Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China department of Cardiac Intensive Care Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing Anzhen Hospital Capital Medical University Beijing China department of Cardiovascular Surgery Fujita Health University School of Medicine Toyoake Aichi-1192 Japan department of Cardiovascular Surgery Groupe Hospitalier Pitié-Salpêtrière University Pierre et Marie Curie APHP Paris France department of Cardiac Surgery APHP H?pitaux Universitaires Henri Mondor Créteil F-94010 France department of Cardiovascular Surgery Union Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China department of Cardiovascular Surgery Fujian Medical University Union Hospital Fuzhou Fujian China department of Thoracic and Cardiovascular Surgery Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu China department of Cardiovascular Surgery General Hospital of Northern Theater Command Shenyang Liaoning China department of Cardiovascular Surgery Xinqiao Hospital Third Military Medical University Chongqing China department of Cardiovascular Surgery Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Chi

Temporary mechanical circulatory support (tMCS) plays a pivotal role in managing severe or refractory cardiogenic shock (CS), furnishing essential hemodynamic support, and sustaining organ perfusion from hours to weeks, or to even months. In the past decade, the utilization of tMCS has witnessed a significant increase in American and European countries. Meanwhile in Asia, the newly developed concepts and devices constituting tMCS have also made rapid progress. Nevertheless, the absence of a consensus or standardized guidelines, especially for the Asian population considering inherited polymorphism, is evident. To address this knowledge gap, eight associations/ societies and experts in this field came up with the present consensus after repeated discussions, more specifically for the Asian population. It comprehensively elucidates the commonly employed tMCS devices, criteria for patient selection, indications and contraindications, clinical management, and the optimal timing for implantation and weaning. The goal of this statement is to promote the standardized application of tMCS and make reasonable decisions in clinical practice. Full-length version of the consensus can be seen in Supplementary File, http://links. ***/CM9/B883.

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Decomposition of biomass gasification tar model compounds over waste tire pyrolysis char

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Waste Disposal and Sustainable Energy 2022年第2期4卷 75-89页

作者： Amal S.Al-Rahbi Paul T.Williams present address:Applied Sciences department Higher College of TechnologyUniversity of Technology and Applied SciencesMuscatSultanate of Oman School of Chemical and Process Engineering University of LeedsLeedsLS29JTUK

Gasification of biomass produces a syngas containing trace amounts of viscous hydrocarbon tar,which causes serious problems in downstream pipelines,valves and processing equipment.This study focuses on the use of tire-derived pyrolysis char for tar conversion using biomass tar model compounds representative of tar.The catalytic decomposition of tar model compounds,including methylnaphthalene,furfural,phenol,and toluene,over tire char was investigated using a fixed bed reactor at a bed temperature of 700℃and 60 min time on stream.The influence of temperature,reaction time,porous texture,and acidity of the tire char was investigated with the use of methylnaphthalene as the tar model compound.Oxygenated tar model compounds were found to have higher conversion than those containing a single or multi-aromatic ring.The reactivity of tar compounds followed the order of furfural>phenol>toluene>methylnaphthalene.The conversion of the model compounds in the presence of the tire char was much higher than tar thermal cracking.Gas production increased dramatically with the introduction of tire char.The H_(2)potential for the studied tar model compounds was found to be in the range of 40%–50%.The activity of tire char for naphthalene removal was compared with two commercial activated carbons possessing a very well-developed porous texture.The results suggest that the influence of Brunauer-Emmett-Teller surface area of the carbon on tar cracking is negligible compared with the mineral content in the carbon samples.

关键词： Biomass Gasification Syngas Tar Tire Char

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A Novel RGL2-DOF6 Complex Contributes to Primary Seed Dormancy in Arabidopsis thaliana by Regulating a GATA Transcription Factor

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Molecular Plant 2017年第10期10卷 1307-1320页

作者： Pratibha Ravindran Vivek Verma Petra Stamm Prakash P. Kumar department of Biological Sciences Faculty of Science National University of Singapore Singapore 117543 Singapore present address: department of biosciences Durham University South Road Durham DH1 3LE UK

The DELLA protein RGA-LIKE2 （RGL2） is a key transcriptional repressor of gibberellic acid （GA） signaling that regulates seed germination. We identified GATA12, a gene encoding a GATA-type zinc finger transcription factor, as one of the downstream targets of RGL2 in Arabidopsis thaliana. Our data show that freshly harvested （unstratified） seeds of GATA 12 antisense suppression lines have reduced dormancy compared with the wild-type, while ectopic expression lines show enhanced seed dormancy. We show that GATA12 expression is negatively regulated by GA, and its transcript levels decline dramatically under dormancy- breaking conditions such as dry storage and cold stratification of seeds. GATA12 promoter has several GAMYB- and DOF-associated motifs that are known to be GA- and RGL2-responsive, respectively. Chromatin immunoprecipitation assay showed that a protein complex containing RGL2 can bind to GATA12 promoter and thereby regulate its expression. RGL2 lacks a DNA binding domain and requires a transcription factor to induce GATA12 expression. Our data show that this RGL2-containing protein complex includes DNA BINDING1 ZINC FINGER6 （DOF6）, which is a known negative regulator of germination in freshly harvested seeds. We further show that this novel RGL2-DOF6 complex is required for activating GATA12 expression, thus revealing a molecular mechanism to enforce primary seed dormancy.

关键词： seed germination primary dormancy DELLA RGL2 DOF6 gibberellin

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Water Responsive Fabrics with Artificial Leaf Stomata

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Advanced Fiber Materials 2023年第3期5卷 1076-1087页

作者： Lihong Lao Hedan Bai Jintu Fan department of Fiber Science&Apparel Design Cornell UniversityIthacaNY 14853USA present address:department of Materials Science and Engineering University of Illinois Urbana-ChampaignUrbanaIL 61801USA Sibley School of Mechanical and Aerospace Engineering Cornell UniversityIthacaNY 14853USA present address:Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA School of Fashion and Textiles Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Due to fiber swelling,textile fabrics containing hygroscopic fibers tend to decrease pore size under wet or increasing humid-ity and moisture conditions,the reverse being true.Nevertheless,for personal thermal regulation and comfort,the opposite is desirable,namely,increasing the fabric pore size under increasing humid and sweating conditions for enhanced ventila-tion and cooling,and a decreased pore size under cold and dry conditions for heat retention.This paper describes a novel approach to create such an unconventional fabric by emulating the structure of the plant leaf stomata by designing a water responsive polymer system in which the fabric pores increase in size when wet and decrease in size when dry.The new fabric increases its moisture permeability over 50%under wet conditions.Such a water responsive fabric can find various applications including smart functional clothing and sportswear.

关键词： Breathable fabric Fabric pores Hydrogel Leaf stomata Water responsive

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A Framework for Enhancing Privacy and Anonymity in Blockchain-Enabled IoT Devices

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Computers, Materials & Continua 2024年第3期78卷 4263-4282页

作者： Muhammad Saad Muhammad Raheel Bhutta Jongik Kim Tae-Sun Chung department of Artificial Intelligence Ajou UniversitySuwon443-749Korea department of Electrical and Computer Engineering University of Utah Asia CampusIncheon21985Korea department of Artificial Intelligence Chungnam National UniversityDaejeon34134Korea

With the increase in IoT(Internet of Things)devices comes an inherent challenge of security.In the world today,privacy is the prime concern of every individual.Preserving one’s privacy and keeping anonymity throughout the system is a desired functionality that does not come without inevitable trade-offs like scalability and increased complexity and is always exceedingly difficult to manage.The challenge is keeping confidentiality and continuing to make the person innominate throughout the system.To address this,we present our proposed architecture where we manage IoT devices using blockchain technology.Our proposed architecture works on and off blockchain integrated with the closed-circuit television(CCTV)security camera fixed at the rental property.In this framework,the CCTV security camera feed is redirected towards the owner and renter based on the smart contract conditions.One entity(owner or renter)can see the CCTV security camera feed at one time.There is no third-party dependence except for the CCTV security camera deployment phase.Our contributions include the proposition of framework architecture,a novel smart contract algorithm,and the modification to the ring signatures leveraging an existing cryptographic technique.Analyses are made based on different systems’security and key management areas.In an empirical study,our proposed algorithm performed better in key generation,proof generation,and verification times.By comparing similar existing schemes,we have shown the proposed architectures’advantages.Until now,we have developed this system for a specific area in the real world.However,this system is scalable and applicable to other areas like healthcare monitoring systems,which is part of our future work.

关键词： Privacy anonymity blockchain IoT smart contracts

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ASLP-DL—A Novel Approach Employing Lightweight Deep Learning Framework for Optimizing Accident Severity Level Prediction

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Computers, Materials & Continua 2024年第2期78卷 2535-2555页

作者： Saba Awan Zahid Mehmood department of Software Engineering University of Engineering and TechnologyTaxila47050Pakistan department of Computer Engineering University of Engineering and TechnologyTaxila47050Pakistan

Highway safety researchers focus on crash injury severity,utilizing deep learning—specifically,deep neural networks(DNN),deep convolutional neural networks(D-CNN),and deep recurrent neural networks(D-RNN)—as the preferred method for modeling accident severity.Deep learning’s strength lies in handling intricate relation-ships within extensive datasets,making it popular for accident severity level(ASL)prediction and classification.Despite prior success,there is a need for an efficient system recognizing ASL in diverse road conditions.To address this,we present an innovative Accident Severity Level Prediction Deep Learning(ASLP-DL)framework,incorporating DNN,D-CNN,and D-RNN models fine-tuned through iterative hyperparameter selection with Stochastic Gradient Descent.The framework optimizes hidden layers and integrates data augmentation,Gaussian noise,and dropout regularization for improved generalization.Sensitivity and factor contribution analyses identify influential predictors.Evaluated on three diverse crash record databases—NCDB 2018–2019,UK 2015–2020,and US 2016–2021—the D-RNN model excels with an ACC score of 89.0281%,a Roc Area of 0.751,an F-estimate of 0.941,and a Kappa score of 0.0629 over the NCDB dataset.The proposed framework consistently outperforms traditional methods,existing machine learning,and deep learning techniques.

关键词： Injury severity prediction deep learning feature

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A high aspect ratio surface micromachined accelerometer based on a SiC-CNT composite material

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Microsystems & Nanoengineering 2024年第2期10卷 219-230页

作者： Jiarui Mo Shreyas Shankar Roberto Pezone Guoqi Zhang Sten Vollebregt Laboratory of Electronic Components Technology and Materials(ECTM)Department of MicroelectronicsDelft University of TechnologyDelftThe Netherlands

Silicon carbide(SiC)is recognized as an excellent material for microelectromechanical systems(MEMS),especially those operating in challenging environments,such as high temperature,high radiation,and corrosive environments.However,SiC bulk micromachining is still a challenge,which hinders the development of complex SiC MEMS.To address this problem,we present the use of a carbon nanotube(CNT)array coated with amorphous SiC(a-SiC)as an alternative composite material to enable high aspect ratio(HAR)surface micromachining.By using a prepatterned catalyst layer,a HAR CNT array can be grown as a structural template and then densified by uniformly filling the CNT bundle with LPCVD a-SiC.The electrical properties of the resulting SiC-CNT composite were characterized,and the results indicated that the electrical resistivity was dominated by the CNTs.To demonstrate the use of this composite in MEMS applications,a capacitive accelerometer was designed,fabricated,and measured.The fabrication results showed that the composite is fully compatible with the manufacturing of surface micromachining devices.The Young’s modulus of the composite was extracted from the measured spring constant,and the results show a great improvement in the mechanical properties of the CNTs after coating with a-SiC.The accelerometer was electrically characterized,and its functionality was confirmed using a mechanical shaker.

关键词： composite surface electrical

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Gradient inflammation in the pancreatic stump after pancreaticoduodenectomy:Two case reports and review of literature

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World Journal of Clinical Cases 2024年第9期12卷 1649-1659页

作者： Tie-Gong Wang Liang Tian Xiao-Ling Zhang Lei Zhang Xiu-Lei Zhao De-Shuai Kong department of Surgery Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina department of Pathology Cangzhou Central HospitalCangzhou 061000Hebei ProvinceChina

BACKGROUND Postoperative pancreatic fistula(POPF)contributes significantly to morbidity and mortality after pancreaticoduodenectomy(PD).However,the underlying mechanisms remain unclear.This study explored this pathology in the pancreatic stumps and elucidated the mechanisms of POPF following PD.CASE SUMMARY Pathological analysis and 16S rRNA gene sequencing were performed on specimens obtained from two patients who underwent complete pancreatectomy for grade C POPF after PD.Gradient inflammation is present in the pancreatic stump.The apoptosis was lower than that in the normal pancreas.Moreover,neu-trophildominated inflammatory cells are concentrated in the ductal system.No-tably,neutrophils migrated through the ductal wall in acinar duct metaplasia-formed ducts.Additionally,evidence indicates that gut microbes migrate from the digestive tract.Gradient inflammation occurs in pancreatic stumps after PD.CONCLUSION The mechanisms underlying POPF include high biochemical activity in the pancreas,mechanical injury,and digestive reflux.To prevent POPF and address pancreatic inflammation and reflux,breaking the link with anastomotic dehi-scence is practical.

关键词： Pancreaticoduodenectomy Postoperative pancreatic fistula Inflammation Digestive reflux Case report

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OsWRKY62 is a Negative Regulator of Basal and Xa21-Mediated Defense against Xanthomonas orvzae pv. orvzae in Rice

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Molecular Plant 2008年第3期1卷 446-458页

作者： Ying Peng Laura E. Bartley Xuewei Chen Christopher Dardick Mawsheng Chern Randy Ruan Patrick E. Canlas Pamela C. Ronald department of Plant Pathology University of California Davis CA 95616 USA present address: Monsanto Corporation Davis CA 95616 USA present address: USDA-ARS Appalachian Fruit Research Station Kearneysville WV 25430 USA

The rice Xa21 gene, which confers resistance to the bacterial pathogen Xanthomonas oryzae pv. oryzae （Xoo）, encodes a receptor-like kinase, Few components involved in transducing the Xa21-mediated defense response have yet been identified. Here, we report that XA21 binds to a WRKY transcription factor, called OsWRKY62. The OsWRKY62 gene encodes two splice variants （OsWRKY62.1 and OsWRKY62.2）. OsWRKY62.1：smGFP2 and OsWRKY62.2：smGFP2 fusion pro- teins partially localize to the nucleus. Transgenic plants overexpressing OsWRKY62.1 are compromised in basal defense and Xa21-mediated resistance to Xoo. Furthermore, overexpression of OsWRKY62.1 suppresses the activation of defenserelated genes. These results imply that OsWRKY62 functions as a negative regulator of innate immunity in rice, and serves as a critical mediator of both basal and race-specific defense responses.

关键词： rice OsWRKY62 Xa21 defense response.

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Assembly of JAZ–JAZ and JAZ–NINJA complexes in jasmonate signaling

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Plant Communications 2023年第6期4卷 296-312页

作者： X.Edward Zhou Yaguang Zhang Jian Yao Jie Zheng Yuxin Zhou Qing He Javier Moreno Vinh QLam Xiaoman Cao Koichi Sugimoto Leidy Vanegas-Cano Leena Kariapper Kelly Suino-Powell Yuanye Zhu Scott Novick Patrick R.Griffin Feng Zhang Gregg A.Howe Karsten Melcher department of Structural Biology Van Andel InstituteGrand RapidsMI 49503USA Key Laboratory of Pesticide College of Plant ProtectionNanjing Agricultural UniversityNanjingChina MSU-DOE Plant Research Laboratory Michigan State UniversityEast LansingMI 48824USA department of Molecular Medicine UF Scripps Biomedical ResearchJupiterFL 33458USA Plant Resilience Institute Michigan State UniversityEast LansingMI 48824USA department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI 48824USA present address:Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing 210014China present address:Tsukuba-Plant Innovation Research Center University of TsukubaTsukubaIbaraki 305-8572Japan

Jasmonates(JAs)are plant hormones with crucial roles in development and stress resilience.They activate MYC transcription factors by mediating the proteolysis of MYC inhibitors called JAZ proteins.In the absence of JA,JAZ proteins bind and inhibit MYC through the assembly of MYC–JAZ–Novel Interactor of JAZ(NINJA)–TPL repressor complexes.However,JAZ and NINJA are predicted to be largely intrinsically unstructured,which has precluded their experimental structure determination.Through a combination of biochemical,mutational,and biophysical analyses and AlphaFold-derived ColabFold modeling,we characterized JAZ–JAZ and JAZ–NINJA interactions and generated models with detailed,high-confidence domain interfaces.We demonstrate that JAZ,NINJA,and MYC interface domains are dynamic in isolation and become stabilized in a stepwise order upon complex assembly.By contrast,most JAZ and NINJA regions outside of the interfaces remain highly dynamic and cannot be modeled in a single conformation.Our data indicate that the small JAZ Zinc finger expressed in Inflorescence Meristem(ZIM)motif mediates JAZ–JAZ and JAZ–NINJA interactions through separate surfaces,and our data further suggest that NINJA modulates JAZ dimerization.This study advances our understanding of JA signaling by providing insights into the dynamics,interactions,and structure of the JAZ–NINJA core of the JA repressor complex.

关键词： JAZ protein NINJA AlphaFold ColabFold MYC hydrogen-deuterium exchange

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