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Cellular & Molecular Immunology 2021年第11期18卷 1290-1304页

作者： Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier Aix Marseille University CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance CHU Bordeaux Service d’Hématologie Clinique et de Thérapie CellulaireBordeauxFrance Bordeaux University BordeauxFrance Institut National de la Santéet de la Recherche Médicale U1035BordeauxFrance APHM Hôpital de la TimoneMarseille-ImmunopôleMarseilleFrance Établissement Français du Sang Nouvelle Aquitaine BordeauxFrance Innate Pharma Research laboratories Innate PharmaMarseilleFrance

Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor *** human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and *** the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone *** analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological *** profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell *** marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate.

关键词： NK cells scRNASeq AML

Acute Pancreatitis during SARS CoV 2 Infection

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Open Journal of Gastroenterology 2023年第1期13卷 28-32页

作者： Marie Louise Bassène Marième Poléle Fall Alioune Badara Fall Salamata Diallo Coumba Kouba Cissé Téné Sidibé Aï ssé Thioubou Mamadou Ngoné Gueye Hô pital Aristide Le Dantec Avenue Pasteur Dakar Sénégal Hô pital de la paix Ziguinchor Sénégal Hô pital Général Idrissa Pouye Dakar Sénégal

Introduction: Covid-19 is a systemic disease that can spread to all systems. Among the gastrointestinal manifestations, pancreatic involvement can have a major prognostic impact. We report 3 acute pancreatitis cases occurring during Covid-19, in Dakar. Case 1: 65-year-old woman who presented with intense atypical epigastric pain. Physical examination revealed obesity, high blood pressure and abdominal tenderness. Biological tests found increase CRP (134 mg/l) and lipasemia (312 UI/l). Abdominal CT scan showed findings of Balthazar grade C acute pancreatitis. RT-PCR for SARS CoV 2 RT-PCR was positive. The outcome was favorable. Case 2: 56-year-old woman patient with history of nephroangiosclerosis who presented with dyspnea, cough, fever and moderate epigastric pain. Physical examination revealed epigastric tenderness, high blood pressure, anuria. Biological testing, noted increase CRP (96 mg/l), lipasemia (793 UI/l), creatinine (227 mg/l) and urea (3.84 g/l). Abdominal CT scan showed acute edematous pancreatitis findings. SARS CoV 2 RT PCR was positive. The outcome was favorable. Case 3: 27-year-old man who presented with physical asthenia, headache, and epigastric pain. Physical examination found epigastric tenderness. Elevated CRP level was of 102 mg/l and lipasemia level was of 427 UI/l (7N). Abdominal CT scan showed acute edematous pancreatitis findings. SARS CoV 2 RT PCR was positive. The outcome was favorable. Conclusion: Acute pancreatitis can occur during Covid-19 infection. However, the imputability to the Covid-19 disease necessitates to rule out the most common causes.

关键词： Acute Pancreatitis SARS CoV 2 Covid-19

Differences and similarities between mesenchymal stem cell and endothelial progenitor cell immunoregulatory properties against T cells

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World Journal of Stem Cells 2021年第8期13卷 971-984页

作者： Mehdi Razazian Maryam Khosravi Sheyda Bahiraii Georges Uzan Sara Shamdani Sina Naserian Institut national de la santéet de la recherche médicale(Inserm)UnitéMixte de Recherche-Inserm-Ministère de la Défense 1197 Hôpital Paul BrousseVillejuif 94800France Microenvironment&Immunity Unit Institut PasteurParis 75724France Institut national de la santéet de la recherche médicale(Inserm)Unit 1224 Paris 75724France department of Pharmacognosy University of ViennaVienna 1090Austria Paris-Saclay University Villejuif 94800France CellMedex Saint Maur Des Fossés 94100France

Bone-marrow-derived mesenchymal stem cells and endothelial progenitor cells have some interesting biological properties that make them unique for cell therapy of degenerative and cardiovascular *** both cell populations have been already studied and used for their regenerative potentials,recently their special immunoregulatory features have brought much more *** stem cells and endothelial progenitor cells have both proangiogenic functions and have been shown to suppress the immune response,particularly T cell proliferation,activation,and cytokine *** makes them suitable choices for allogeneic stem cell ***,these two cells do not have equal immunoregulatory *** elements including their extraction sources,age/passage,expression of different markers,secretion of bioactive mediators,and some others could change the efficiency of their immunosuppressive ***,to our knowledge,no publication has yet compared mesenchymal stem cells and endothelial progenitor cells for their immunological interaction with T *** review aims to specifically compare the immunoregulatory effect of these two populations including their T cell suppression,deactivation,cytokine production,and regulatory T cells induction ***,it evaluates the implications of the tumor necrosis factor alpha-tumor necrosis factor receptor 2 axis as an emerging immune checkpoint signaling pathway controlling most of their immunological properties.

关键词： Endothelial Progenitor Cells Mesenchymal Stem Cells T cells Immunosuppression Immunoregulation TNFα-TNFR2 signaling pathway

Screening for hypertension-mediated organ damage and aetiology:still of value after 65 years of age?

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Journal of Geriatric Cardiology 2022年第11期19卷 791-801页

作者： delphine Thiolliere Brahim Harbaoui Claire Falandry Marc Bonnefoy Jean-Christophe Lega Pierre lantelme Pierre-Yves Courand Fédération de cardiologie Hôpital de la Croix-Rousse et Hôpital Lyon SudHospices Civils de LyonLyonFrance Universitéde Lyon CREATISCNRS UMR5220INSERM U1044INSA-LyonUniversitéClaude Bernard LyonFrance Service Universitaire de Gériatrie Hôpital Lyon SudHospices Civils de LyonLyonFrance CarMeN UniversitéClaude Bernard Lyon 1OullinsFrance Service de médecine interne et pathologies vasculaires Groupe d’Etude Multidisciplinaires des Maladies Thrombotiques(GEMMAT)Hôpital Lyon SudHospices Civils de LyonLyonFrance Universitéde Lyon Equipe Evaluation et Modélisation des Effets ThérapeutiquesLaboratoire de Biologie et Biométrie EvolutiveCNRS UMR 5558UniversitéClaude BernardLyonFrance

BACKGROUND Secondary forms and hypertension-mediated organ damage(HMOD) may differ between younger and older hypertensive *** aim of the present study was to explore the specificity of HMOD and secondary forms in patients≥ 65 years in comparison to younger ones in a contemporary *** We analysed 938 patients recruited between 2004 and 2014(Cardiology department,Croix-Rousse Hospital,Lyon)who had at baseline HMOD and secondary forms screening among them 190 were≥ 65 *** The mean(2.1±0.8 vs.1.2±0.9,P 10 m/s was the most frequent HMOD in patients≥ 65 years(90.1%),while echocardiographic left ventricular hypertrophy was the most common in the younger patients(45.0%).Among ECG left ventricular indexes,only R wave in aVL lead was significantly more frequently observed in patients≥ 65 years(32.6%) than in younger ones(19.0%,P der patients(respectively;30.5% vs.27.8%,P=0.487).The most frequent aetiology was primary aldosteronism regardless of age,followed by renovascular hypertension(6.3% vs.3.3%,P=0.038).Among older patients,3.2% were treated with adrenalectomy and 6.3% with percutaneous transluminal renal *** Extensive screening of HMOD in older patients may be questionable as nearly all patients had one;aetiology must however be explored as a third of older patients had a secondary form.

关键词： Extensive screening of HMOD in older patients may be questionable as nearly all patients had one aetiology must however be explored as a third of older patients had a secondary form

Effects of extracts from Hibiscus macranthus and Basella alba mixture on testosterone production in vitro in adult rat testes slices

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Asian Journal of Andrology 2006年第1期8卷 111-114页

作者： Paul E Moundipa Silvère Ngouela Pierre Kamtchouing Etienne Tsamo Félicité M.Tchouanguep Serge Carreau laboratory of Nutrition and Biochemical Toxicology laboratory of Organic Chemistry department of Animal Biology and Physiology University of Yaoundé IP.O.Box 812YaoundéCameroon Faculty of Science University of DschangP.O.Box 67DschangCameroon USC INRA-EA 2608.laboratoire de Biochimie Esplanade de la paixUniversité de Caen14032 Caen-cedexFrance

Aim： To find an in vitro system for the measurement of the androgenic effects of different extracts of Hibiscus macranthus （Malvaceae） and Basella alba （Basellaceae）. Methods： The production of testosterone from testes slices incubated in two media, either Krebs-Henseleit buffer containing 0.5% Bovine serum albumin （BSA） or Dubecco＇s Modified Eagle＇s medium-F12 Ham nutrient mixture （DME/Ham F12）, under a mixture of 5% CO2 in 95% air was determined either in the presence or absence of cofactors and Hibiscus macranthus plus Basella alba （HMBA） extracts. Results： The testosterone production was increased in testes slices incubated in DME/Ham F12 medium in response to the cofactors （49%） and aqueous extracts （34%-60% according to dilutions）. Under the same atmospheric conditions, there was no positive response of the testes slices to either cofactor or HMBA extract stimulation in Krebs-Henseleit buffer containing 0.5% BSA, In further investigations related to the effect of HMBA, the DME/ Ham F12 medium was used. The results obtained from the in vitro test showed that the activity was present mainly in methylene chloride and methanol, since these extracts induced an increase in testosterone production by testes slices. Conclusion： The testes slice system is suitable to be used for further in vitro investigations of the isolation of androgenic bioactive components of plants. （Asian J Androl 2006 Jan; 8： 111-114）

关键词： testis testosterone plant extracts Hibiscus macranthus Basella alba

Portal Thrombosis: Clinical, Etiological and Therapeutic Aspects in the Hepato-Gastroenterology department of the Aristide Le Dantec Hospital in Dakar (Senegal)

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Open Journal of Gastroenterology 2021年第11期11卷 220-229页

作者： Salamata Diallo Coumba Ndaw Diagne Marie Louise Bassène Mamadou Ngoné Gueye Mariéme Polele Fall Mame Aissé Thioubou Cheikh Ahmadou Bamba Cissé Daouda Dia Hôpital Aristide Le Dantec Dakar Sénégal Dakar Senegal Hôpital Idrissa Pouye Dakar Sénégal Dakar Senegal Hôpital de la paix Ziguinchor Sénégal Dakar Senegal

Background: Portal thrombosis (PT) is a rare pathology. Its prevalence is estimated at 1%. Its consequences depend on the acute or chronic nature, the extent of the clot and the etiology. In Sub-Saharan Africa, very few studies have been devoted to it. Patients and Method: The objective of our work was to determine the prevalence of PT and to describe its clinical and etiological presentation as well as its therapeutic management in the Hepato-gastroenterology department of the Aristide Le Dantec hospital in Dakar. This was a retrospective, longitudinal and descriptive study during the period from January 1, 2012, to december 31, 2018. It included all patients followed in ambulatory or inpatient, who presented a PT objectively determined by a medical imaging examination (ultrasound and/or CT scan). Age, gender, clinical and radiological aspects, proposed treatments and etiology of PT were collected. Results: We collected 71 observations. The prevalence of PT was 1.9%. The mean age of the patients was 41 years 15 and 75 years. A predominance of men was found with a sex ratio of 2.73. The clinical manifestations were dominated by abdominal pain (74.6%), ascites (35.7%) and gastrointestinal bleeding (25.4%). Imaging allowed the diagnosis to be made in 50 patients on ultrasound and 21 patients on abdominal CT scan. PT was acute in 5 patients and chronic in 66 patients. Thrombosis was complete in 71.4% of cases and extended to the spleno-mesaraic venous trunk and the superior mesenteric vein in 2.8% and 8.4% respectively. Etiological research found cirrhosis complicated by hepatocellular carcinoma in 67.6% of cases, cirrhosis with cruoric thrombosis in 21.1% of cases, a combined protein C and S deficiency in 1.4% of cases. No aetiology was objectified in 9.9% of cases. Treatment with beta-blockers was initiated in 32 patients. Anticoagulant treatment was performed in one patient. Evo

关键词： Portal Thrombosis Cirrhosis Portal Hypertension

Refractory intraocular hypertension after dexamethasone-implant intravitreal injection treated with Preserflo MicroShunt implantation

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 656-658页

作者： Lucas Sejournet Amina Rezkallah Olivier Loria laurent Kodjikian Thibaud Mathis Philippe denis department of Ophthalmology Hôpital de la Croix-RousseHospices Civils de LyonLyon 69361France laboratoire UMR-CNR 5510 Matéis UniversitéLyon 1Villeurbane 69100France

dear Editor,Herein,we report a case of a patient who presented with refractory ocular hypertension(OHT)after a dexamethasone implant(deX-I)*** pressure(IOP)was finally managed after Preserflo Micro Shunt implantation,... 详细信息

关键词： injection hypertension after

Reply to ‘Comment to: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia’

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Cellular & Molecular Immunology 2021年第5期18卷 1350-1352页

作者： Adeline Crinier Bertrand Escalière Emilie Narni-Mancinelli Eric Vivier Aix Marseille University CNRSINSERMCentre d’Immunologie de Marseille-LuminyMarseilleFrance APHM Hôpital de la TimoneMarseille-ImmunopôleMarseilleFrance Innate Pharma Research laboratories Innate PharmaMarseilleFrance

We thank Melsen et *** their interest in our *** remarks allow us to clarify key aspects of our work on human bone marrow NK cell biology.1 Our study reports the unsupervised single-cell analysis of NK cells from eight healthy donors and eight acute myeloid leukemia(AML)patients.1 First,we detected an adaptive NK cell subset that correlated with the cytomegalovirus(CMV)positivity status of the donors.

关键词： myeloid acute

New perspectives for investigating respiratory failure induced by cervical spinal cord injury

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Neural Regeneration Research 2014年第22期9卷 1949-1951页

作者： Marcel Bonay Stéphane Vinit Université de Versailles Saint-Quentin-en-Yvelines Unité End:icapUFR des Sciences de la Santé–Simone Veil78180 Montigny-le-BretonneuxFrance Service de Physiologie-Explorations Fonctionnelles H?pital Ambroise Paré Assistance Publique-H?pitaux de Paris(AP-HP)Groupe Hospitalier Paris Ile-de-France Ouest92104 BoulogneBillancourtFrance

Traumatic cervical spinal cord injury （SCI）, with an annual incidence of 12,000 new cases in USA （NSCISC 2013）, causes devastating locomotor and respiratory paralysis and unfortunately compromises the human patient＇s lifespan. The severity of the injury depends on the degree and the extent of the initial trauma. In fact, respiratory failure is the leading cause of mortality following upper cervical SCI. However, 80% of the injuries are incomplete, allowing some modest spontaneous recovery. To date, no effective treatment is available in order to restore the loss of function.

关键词： SCI New perspectives for investigating respiratory failure induced by cervical spinal cord injury CPP

Multiple evanescent white dot syndrome relapse following BNT162b2 mRNA COVID-19 vaccination

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国际眼科杂志:英文版 2023年第10期16卷 1724-1726页

作者： Lucas Sejournet laurent Kodjikian Amina Rezkallah Philippe denis Thibaud Mathis Olivier Loria department of Ophthalmology Hôpital de la Croix-RousseHospices Civils de LyonLyon F-69004France 2Laboratoire UMR-CNR 5510 MatéisUniversitéLyon 1Villeurbane 69100France

dear Editor,We report a case of multiple evanescent white dot syndrome(MEWDS)relapse following mRNA corona virus disease 2019(COVID-19)*** is a choroidal inflammatory disease belonging to the group of“white dot syndromes”group,with an excellent prognosis[1].MEWDS is usually idiopathic,but there have been reports of MEWDS following viral infection or vaccination[1-2].

关键词： vaccination relapse white