检索结果-南通市图书馆

Mitochondrial energy metabolism in diabetic cardiomyopathy:Physiological adaption,pathogenesis,and therapeutic targets

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第8期137卷 936-948页

作者： Wanlin Ye Kun Han Maodi Xie Sheyu Li Guo Chen Yanyan Wang Tao Li Department of Anesthesiology Laboratory of Mitochondria and MetabolismNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Anesthesiology West China Second University HospitalSichuan UniversityChengduSichuan 610041China Key laboratory of Birth Defects and Related Diseases of Women and Children Sichuan UniversityMinistry of EducationChengduSichuan 610041China Department of Endocrinology and Metabolism Division of Guideline and Rapid RecommendationCochrane China CenterMAGIC China CenterChinese Evidence-Based Medicine CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Nursing Key laboratory of Sichuan Province West China HospitalSichuan UniversityChengduSichuan 610041China

Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes,which could eventually develop heart failure and leads to the death of the *** blood glucose control and medications to heart failure show beneficial effects on this disease,there is currently no specific treatment for diabetic *** the past few decades,the pathophysiology of diabetic cardiomyopathy has been extensively studied,and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic *** this review,we summarize the latest research in the field of diabetic cardiomyopathy,focusing on mitochondrial damage and adaptation,altered energy substrates,and potential therapeutic targets.A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.

关键词： Mitochondria Mitochondrial energy metabolism Diabetic cardiomyopathies Physiology Physiological adaption Pathogenesis Therapeutics

Dynamic aggregation of carbon dots self-stabilizes symmetry breaking for exceptional hydrogen production with near-infrared light

在线全文

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2024年第1期5卷 385-397页

作者： Qi Zhang Ya Zhang Hu Shi Hongxia Zhang Jianghong Zhao Zhanfeng Zheng Hengquan Yang Pengju Yang School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuanChina Engineering Research center of Ministry of Education for Fine Chemicals Shanxi UniversityTaiyuanChina Institute of Molecular Science Shanxi UniversityTaiyuanChina State Key laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuanChina

Developing new photosystems that integrate broad-band near-infrared(NIR)light harvesting and efficient charge separation is a long-sought goal in the photocatalytic *** this work,we develop a novel photochemical strategy to prepare light-active carbon dots(CDs)under room temperature and discover that the aggregation of CDs can broaden the light absorption to the NIR region due to the electronic couplings between neighboring ***,the dynamic noncovalent interactions within CD aggregates can stabilize symmetry breaking and thus induce large dipole moments for charge separation and ***,the weak non-covalent interactions allow for flexible design of the aggregated degrees and the local electronic structures of CD aggregates,further strengthening NIR-light harvesting and charge separation *** a result,the CD aggregates achieve a record apparent quantum yield of 13.5%at 800 nm,which is one of the best-reported values for NIR-light-driven hydrogen photosynthesis to ***,we have prepared a series of different CDs and also observed that these CDs after aggregation all exhibit outstanding NIR-responsive photocatalytic hydrogen production activity,suggesting the universality of aggregation-enhanced *** discovery opens a new promising platform for using CD aggregates as efficient light absorbers for solar conversion.

关键词： aggregation charge separation hydrogen production near-infrared light photocatalysis

Improved hydrogen storage kinetics of MgH_(2) using TiFe_(0.92)Mn_(0.04)Co_(0.04) with in-situ generated α-Fe as catalyst

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Materials Reports(Energy) 2024年第1期4卷 95-103页

作者： Zefeng Li Yangfan Lu Jingfeng Wang Yu'an Chen Qian Li Fushen Pan College of Materials Science and Engineering National Engineering Research Center for Magnesium AlloysChongqing UniversityChongqing400044PR China National Key laboratory of Advanced Casting Technologies Chongqing UniversityChongqing400044PR China Chongqing Institute of New Energy Storage Materials and Equipment Chongqing401135PR China

While TiFe alloy has recently attracted attention as the efficient catalyst to enhance de/hydrogenation rates of Mg/MgH_(2),the difficulty of its activation characteristics has hindered further improvement of reaction ***,we report that the TiFe_(0.92)Mn_(0.04)Co_(0.04) catalyst can overcome the abovementioned *** synthesized MgH_(2)-30 wt% TiFe_(0.92)Mn_(0.04)Co_(0.04) can release 4.5 wt%of hydrogen in 16 min at 250℃,three times as fast as MgH_(2).The activation energy of dehydrogenation was as low as 84.6 kJ mol^(-1),which is 46.8%reduced from pure MgH_(2).No clear degradation of reaction rates and hydrogen storage capacity was observed for at least 30 *** studies reveal that TiFe_(0.92)Mn_(0.04)Co_(0.04) partially decomposes to in-situ generatedα-Fe particles dispersed on TiFe_(0.92)Mn_(0.04)Co_(0.04).The presence ofα-Fe reduces the formation of an oxide layer on TiFe_(0.92)Mn_(0.04)Co_(0.04),enabling the activation *** the same time,the hydrogen incorporation capabilities of TiFe_(0.92)Mn_(0.04)Co_(0.04) can provide more hydrogen diffusion paths,which promote hydrogen dissociation and *** discoveries demonstrate the advanced nature and importance of combining the in-situ generatedα-Fe with TiFe_(0.92)Mn_(0.04)Co_(0.04).It provides a new strategy for designing highly efficient and stable catalysts for Mg-based hydrogen storage materials.

关键词： Hydrogen storage materials Magnesium De/hydrogenation kinetics Catalyst

协同光热效应及纳米酶的高效抗菌活性（英文）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Materials 2024年

作者：李蓉陈莎莎张新刚曾帆宋先印尹佳蒋昌忠 Key laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan Province Department of Physics and Synergetic Innovation Center for Quantum Effects and Applications Hunan Normal University Hunan Provincial Key laboratory of Animal Intestinal Function and Regulation College of Life Sciences Hunan Normal University College of Materials Science and Engineering Hunan University

耐药菌的不断出现已成为人类和动物健康的严重威胁.开发高效、低耐药的新型非抗生素治疗药物是对抗耐药菌的有效策略.在这里,我们设计了一种新型的复合结构,即中空金属有机框架(MOF)包裹金纳米棒并负载铂纳米颗粒(Au NR@H-ZIF-8@Pt)用...

耐药菌的不断出现已成为人类和动物健康的严重威胁.开发高效、低耐药的新型非抗生素治疗药物是对抗耐药菌的有效策略.在这里,我们设计了一种新型的复合结构,即中空金属有机框架(MOF)包裹金纳米棒并负载铂纳米颗粒(Au NR@H-ZIF-8@Pt)用以对抗耐药细菌.Au NR@H-ZIF-8@Pt复合结构具有双重作用:(1)在近红外光照射下表现出优异的光热转换效率,从而实现基于光热效应的抗菌作用;(2)表现出高效的过氧化物酶样活性,通过原位产生的活性氧(ROS)有效杀灭细菌.结合光热和催化作用进行体外抗菌实验, Au NR@H-ZIF-8@Pt表现出高效、快速、广谱的抗菌活性(对铜绿假单胞菌和金黄色葡萄球菌的灭菌效果分别高达99.7%和98.3%).此外,体内实验进一步证明了该材料在促进细菌感染创面愈合方面的优势.本研究不仅有利于新型生物纳米材料的设计,也为对抗耐药菌提供了新思路.

关键词：

Tuning the surface electronic structure of noble metal aerogels to promote the electrocatalytic oxygen reduction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第2期89卷 557-564,I0013页

作者： Hongxing Yuan Wei Gao Xinhao Wan Jianqi Ye Dan Wen State Key laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072ShaanxiChina

The sluggish kinetics of the oxygen reduction reaction(ORR)is the bottleneck for various electrochemical energy conversion *** the electronic structure of electrocatalysts by ligands has received particular attention in deriving valid ORR ***,the surface electronic structure of Ptbased noble metal aerogels(NMAs)was modulated by various organic ligands,among which the electron-withdrawing ligand of 4-methylphenylene effectively boosted the ORR *** calculations suggested the smaller energy barrier for the transformation of O^(*) to OH^(*) and downshift the d-band center of Pt due to the interaction between 4-methylphenylene and the surface metals,thus enhancing the ORR intrinsic *** Pt3Ni and Pt Pd aerogels with 4-methylphenylene decoration performed significant enhancement in ORR activity and durability in different ***,the 4-methylphenylene modified Pt Pd aerogel exhibited the higher halfwave potential of 0.952 V and the mass activity of 10.2 times of commercial Pt/*** work explained the effect of electronic structure on ORR electrocatalytic properties and would promote functionalized NMAs as efficient ORR electrocatalysts.

关键词： Noble metal aerogels Surface electronic structure ORR Electrocatalyst Organic ligands

A state of art review on time series forecasting with machine learning for environmental parameters in agricultural greenhouses

在线全文

学校读者我要写书评

暂无评论

Information Processing in Agriculture 2024年第2期11卷 143-162页

作者： Gedi Liu Keyang Zhong Huilin Li Tao Chen Yang Wang National Innovation center for Digital Fishery China Agricultural University100083 BeijingChina Key laboratory of Smart Farming Technologies for Aquatic Animal and Livestock Ministry of Agriculture and Rural AffairsChina Agricultural University100083 BeijingChina Beijing Engineering and Technology Research center for Internet of Things in Agriculture China Agricultural University100083 BeijingChina College of Information and Electrical Engineering China Agricultural University100083 BeijingChina Department of Chemical and Process Engineering University of SurreyGU27XH GuildfordUnited Kingdom

Agricultural greenhouse production has to require a stable and acceptable environment,it is therefore essential for future greenhouse production to obtain full and precisely internal dynamic environment *** modeling based on machine learning methods,e.g.,intelligent time series prediction modeling,is a popular and suitable way to solve the above *** this article,a systematic literature review on applying advanced time series models has been systematically conducted via a detailed analysis and evaluation of 61 pieces selected from 221 *** historical process of time series model application from the use of data and information strategies was first ***,the accuracy and generalization of the model from the selection of model parameters and time steps,providing a new perspective for model development in this field,were compared and ***,the systematic review results demonstrate that,compared with traditional models,deep neural networks could increase data structure mining capabilities and overall information simulation capabilities through innovative and effective structures,thereby it could also broaden the selection range of environmental parameters for agricultural facilities and achieve environmental prediction end-to-end optimization via intelligent time series model based on deep neural networks.

关键词： Horticultural greenhouse environment Time series algorithms Prediction Deep neural networks

Graph neural network based method for robot path planning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomimetic Intelligence & Robotics 2024年第1期4卷 80-87页

作者： Xingrong Diao Wenzheng Chi Jiankun Wang Shenzhen Key laboratory of Robotics Perception and Intelligence Department of Electronic and Electrical EngineeringSouthern University of Science and TechnologyShenzhen 518055China Robotics and Microsystems center School of Mechanical and Electric EngineeringSoochow UniversitySuzhou 215021China Jiaxing Research Institute Southern University of Science and TechnologyJiaxing 314000China

Sampling-based path planning is widely used in robotics,particularly in high-dimensional state *** the path planning process,collision detection is the most time-consuming ***,we propose a learning-based path planning method that reduces the number of collision *** develop an efficient neural network model based on graph neural *** model outputs weights for each neighbor based on the obstacle,searched path,and random geometric graph,which are used to guide the planner in avoiding *** evaluate the efficiency of the proposed path planning method through simulated random worlds and real-world *** results demonstrate that the proposed method significantly reduces the number of collision checks and improves the path planning speed in high-dimensional environments.

关键词： Graph Neural Network(GNN) Collision detection Sampling-based path planning

Advancing CRISPR base editing technology through innovative strategies and ideas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2024年

作者： Xiongwei Fan Yang Lei Liren Wang Xiushan Wu Dali Li The center for Heart Development College of Life Science Hunan Normal University Shanghai Frontiers Science Research Base of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Guangdong Provincial Key laboratory of Pathogenesis Targeted Prevention and Treatment of Heart Disease

The innovation of CRISPR/Cas gene editing technology has developed rapidly in recent years. It is widely used in the fields of disease animal model construction, biological breeding, disease diagnosis and screening, gene therapy, cell localization, cell lineage tracking, synthetic biology, information storage, etc. However, developing idealized editors in various fields is still a goal for future development. This article focuses on the development and innovation of non-DSB editors BE and PE in the platform-based CRISPR system. It first explains the application of ideas for improvement such as “substitution”, “combination”, “adaptation”, and “adjustment” in BE and PE development and then catalogues the ingenious inversions and leaps of thought reflected in the innovations made to CRISPR technology. It will then elaborate on the efforts currently being made to develop small editors to solve the problem of AAV overload and summarize the current application status of editors for in vivo gene modification using AAV as a delivery system. Finally, it summarizes the inspiration brought by CRISPR/Cas innovation and assesses future prospects for development of an idealized editor.

关键词：

The Magnaporthe oryzae effector Avr-PikD suppresses rice immunity by inhibiting an LSD1-like transcriptional activator

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The Crop Journal 2024年第2期12卷 482-492页

作者： Jiayuan Guo Yiling Wu Jianqiang Huang Kaihui Yu Meilian Chen Yijuan Han Zhenhui Zhong Guodong Lu Yonghe Hong Zonghua Wang Xiaofeng Chen Fujian Universities Engineering Research center of Marine Biology and Drugs Fuzhou Institute of OceanographyCollege of Geography and OceanographyMinjiang UniversityFuzhou 350108FujianChina Rice Research Institute Fujian Academy of Agricultural SciencesFuzhou 350018FujianChina Ministerial and Provincial Joint Innovation center for Safety Production of Cross-Strait Crops Minjiang UniversityFuzhou 350108FujianChina State Key laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Avirulence effectors(Avrs),encoded by plant pathogens,can be recognized by plants harboring the corresponding resistance proteins,thereby initiating effector-triggered immunity(ETI).In susceptible plants,however,Avrs can function as effectors,facilitating infection via effector-triggered susceptibility(ETS).Mechanisms of Avr-mediated ETS remain largely *** we report that the Magnaporthe oryzae effector Avr-PikD enters rice cells via the canonical cytoplasmic secretion pathway and suppresses rice basal ***-PikD interacts with an LSD1-like transcriptional activator AKIP30 of rice,and AKIP30 is also a positive regulator of rice immunity,whereas Avr-PikD impedes its nuclear localization and suppresses its transcriptional *** summary,*** delivers Avr-PikD into rice cells to facilitate ETS by inhibiting AKIP30-mediated transcriptional regulation of immune response against ***.

关键词： Magnaporthe oryzae Avirulence effector Avr-PikD Effector-triggered susceptibility Rice immunity Transcriptional activator