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Upregulation of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis by a combination of Yinyanghuo(Herba Epimedii Brevicornus) and Cheqianzi(Semen Plantaginis) improves erectile function in spontaneously hypertensive rats

引用

Journal of Traditional Chinese Medicine 2020年第5期40卷 836-844页

作者： Zhang Hongguan Liu Yude Rao Lian Cen Yanyou Cheng Kaili Guangzhou University of Chinese Medicine Guangzhou 510405China partment of cardiovascularmedicine the First Affiliated Hospital of Guangzhou Universityof Chinese MedicineGuangzhou 510405China

OBJECTIVE:To evaluate the effects of a combination of Yinyanghuo(Herba Epimedii Brevicornus)(HEB)and Cheqianzi(Semen Plantaginis)(SP)on erectile dysfunction caused by essential hypertension in spontaneously hypertensive rats(SHRs),and to elucidate the role of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor(ACE2/Ang[1-7]/Mas receptor)axis in this ***:A total of 24 SHRs were randomly assigned to three groups:SHR-control,low-dose(12.5 g/kg)and high-dose(25 g/kg)HEB+SP(HEBSP).Eight Wistar-Kyoto rats were used as normal *** was administered by oral gavage for 28 *** function was measured once a week using the Heaton *** 4 weeks of treatment,the corpus cavernosum was harvested from each rat to measure nitric oxide(NO),nitric oxide synthase(e NOS)and Ang(1-7)levels,as well as ACE2,Mas receptor and neuronal nitric oxide synthase(n NOS)protein ***:After 4 weeks of treatment,HEBSP significantly increased erectile function in the treated group compared with SHR-control group(P<0.01).Additionally,HEBSP treatment significantly increased cavernosal levels of Ang(1-7),e NOS and ***,HEBSP significantly elevated the expression levels of ACE2,Mas receptor and n *** beneficial effects were elevated in the high-dose HEBSP ***:HEBSP improved erectile function in SHRs by upregulating the ACE2/Ang(1-7)/Mas receptor axis,e NOS and n NOS pathways.

关键词： Rats,Inbred SHR Peptidyl-Dipeptidase A Angiotensins Nitric oxide synthase Corpus cavernosum Yinyanghuo(Herba Epimedii Brevicornus) Cheqianzi(Semen Plantaginis)

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