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Unas olimpiadas de alta tecnología

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今日中国（西文版） 2022年第1期 19-21页

作者： ZHENG JINWU Diario de Ciencia de China

China tiene una visión a largo plazo sobre las innovaciones tecnológicas para Beijing 2022.E L Comité Organizador de Beijing para los Juegos olímpicos y Paialfnipicos de Invienio de 2022 ha declarado que hará que... 详细信息

关键词： alta Beijing port

Complications of transsphenoidal surgery for sellar region： intracranial vessel injury

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Chinese medical Journal 2009年第10期122卷 1154-1156页

作者： ZHOU Wei-guo YANG Zhan-quan department ol Otolaryngology Head and Neck Surgery Beljmg Tongren Hospital Capital Medical University Key Laboratory of Otolaryngology Head and Neck Surgery (Capital medical University) Ministry of Education Beijing 100730 China department of Otolaryngology Head and Neck Surgery China-Japan Union Hospital Jilin University Changchun Jilin 130041 China

Background Intracranial vessel injury is a severe complication of transsphenoidal surgery （TSS） for lesions of sellar region. The purpose of this study was to improve recognition of the complication. methods The clinical data of 400 cases of TSS for sellar region from 1964 to 2004 were reviewed retrospectively. Ten patients with complications of intracranial vessel injury were included in this study, 7 underwent transsphenoidal microsurgery and 3 underwent endoscopic TSS. Subarachnoid hemorrhage （SAH） occurred in 8 cases, hemorrhage of cavernous sinus in one, and post-operative cerebral hemorrhagic infarction caused by thrombosis of injured right internal carotid artery in one. The clinical data of all the patients were analyzed. Results The SAH resulted from hemorrhage of residues of tumor in 2 patients and from damaged sellar and arachnoidea in 6 patients. The cause of hemorrhage of anterior intercavernous sinus was malformation of anterior intercavernous sinus. The reason of thrombus of internal carotid artery was manipulation of operation. Three patients died and six patients were cured. One patient lived with hemiplegia. Conclusions The cause of intracranial vessels injury of TSS is complicated. detailed anatomic knowledge of seller and skilled operation is helpful to reduce the complication.

关键词： transsphenoidal surgery subarachnoid hemorrhage complication pituitary adenoma

El esquíacrobático:la apuesta de China

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今日中国（西文版） 2022年第1期 72-73页

作者： LIAO HAN Facultad de Espanol del Instituto de Lenguas Extranjeras de la Universidad Normal de la Capital

El país pone en esta disciplina sus esperanzas de conseguir algunas medallas de *** que se acercan los Juegos olímpicos de Invierno Beijing 2022,los deportes de hielo y nieve vienen estando más en el foco de atenei... 详细信息

关键词： porte China rob

El gran aporte de los voluntarios

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今日中国（西文版） 2022年第1期 30-31页

作者： LIAO HAN Facultad de Espanol del Instituto de Lenguas Extranjeras de la Universidad Normal de la Capital

Serán la imagen cultural del país durante los Juegos olímpicos de Invierno.mÁS de un millón de personas postularon para ser voluntarias en los Juegos olímpicos de Invierno Beijing 2022,pero al final solo 39.000 ... 详细信息

关键词： convert tar vol

Clinical and Radiological Profile of Acute Fibrinous and Organizing Pneumonia： A Retrospective Study

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Chinese medical Journal 2015年第20期128卷 2701-2706页

作者： Jing-Hong Dai Hui Li Wei Shen Li-Yun miao Yong-Long Xiao mei Huang meng-Shu Cao Yang Wang Bin Zhu Fan-Qing meng Hou-Rong Cai department of Respiratory medicine The Affiliated Drum Tower Hospital ol Nanjing University Medical School Nanjing Jiangsu 210008 China department of Radiology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China department of Pathology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China

Background： Acute fibrinous and organizing pneumonia （AFOP） is a unique pathological entity with intra-alveolar fibrin in the form of ＂fibrin balls＂ and organizing pneumonia. It was divided into rare idiopathic interstitial pneumonia according to the classification notified by American Thoracic Society/European Respiratory Society in 2013. As a rare pathological entity, it is still not well known and recognized by clinicians. We reviewed the clinical features of 20 patients with AFOP diagnosed in a teaching hospital. methods： The medical records of 20 patients with biopsy-proven diagnosis of AFOP were retrospectively reviewed. The patients＇ symptoms, duration of the disease, comorbidities, clinical laboratory data, pulmonary function testing, radiographic studies, and the response to treatment were extracted and analyzed. Results： Fever was the most common symptom and was manifested in 90% of AFOP patients. For clinical laboratory findings, systematic inflammatory indicators, including C-reactive protein and erythrocyte sedimentation rate, were significantly higher than normal ill AFOP patients. In accordance with this increased indicators, injured liver functions were common in AFOP patients. Inversely, AFOP patients had worse clinical conditions including anemia and hypoalbuminemia. For pulmonary function testing, AFOP patients showed the pattern of restrictive mixed with obstructive ventilation dysfunction. For high-resolution computerized tomography （HRCT） findings, the most common pattern for AFOP patients was lobar consolidation which was very similar to pneumonia. However, unlike pneumonia, AFOP patients responded well to glucocorticoids. Conclusion： Patients with AFOP manifest as acute inflammatory-like clinical laboratory parameters and lobar consolidation on HRCT, but respond well to steroid.

关键词： Acute Fibrinous and Organizing Pneumonia Clinical Features High-resolution Computerized Tomography InflammatoryIndicators

SNCG shRNA suppressed breast cancer cell xenograft formation and growth in nude mice

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Chinese medical Journal 2011年第10期124卷 1524-1528页

作者： SHEN Pei-hong FAN Qing-xia LI Yan-wei ZHANG Wei HE Xiao-kai WANG Zhen ZHANG Yun-han department of Oncology the First Affiliated Hospital Zhengzhou University Zhengzhou Henan 450051 China department ol Pathology the First Affiliated Hospital Zhengzhou University Zhengzhou Henan 450051 China department of Pathology the Fifth Affiliated Hospital Zhengzhou University Zhengzhou Henan 450052 China Graduate School Zhengzhou University Zhengzhou Henan 450001 China

Background Overexpression of breast cancer-specific gene 1 （SNCG） is associated with poor prognosis in advanced breast cancer patients. This study aimed to determine the effects of SNCG knockdown in breast cancer cells by using small hairpin RNA （shRNA）.methods Four different SNCG shRNA oligonucleotides were designed and chemically synthesized to construct mammalian expression vectors. These vectors were then stably transfected into a breast cancer mCF-7 cell line to knockdown SNCG expression. After SNCG knockdown was confirmed, the stable cell lines were inoculated into nude mice. SNCG mRNA and protein expressions were analyzed by semi-quantitative reverse transcription-polymerase chain reaction （RT-PCR） and immunohistochemistry, respectively in both the stable cell lines and *** All four SNCG shRNA constructs significantly reduced SNCG mRNA and protein levels in mCF-7 cells, as compared to the unrelated sequence control shRNA and the liposome control mice （P〈0.05）. SNCG-knockdown mCF-7cells formed significantly smaller tumor masses than cells expressing the unrelated sequence control or the liposome control mice （P〈0.05）.Conclusion SNCG shRNA effectively suppressed breast cancer cell formation in vivo and may be a useful clinical strategy to control breast cancer

关键词： breast cancer SNCG small hairpin RNA mCF-7 cells xenografi

Brain metastases Treated with Radio surgery Alone:An Alternative to Whole Brain Radiotherapy?

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癌症 2003年第7期22卷 784-784页

作者： Toshinori Hasegawa Douglas Kondziolka John C.Flickinger Anand Germanwala L.Dade Lunsford m.D. M.D.M.Sc.F.R.C.S.(C)M.D.M.D.M.D.

OBJECTIVE:Whole brain radiotherapy(WBRT)provides benefit for patients with b rain metastases but may result in neurological toxicity for patien ts with extended survival *** reotactic radiosurgery in combination with WBRT has become an important approach,but the value of WBRT has been *** an alternative to WBRT,we managed patients with stereotactic radiosurgery alone,evaluated pati ents’outcomes,and assessed prognostic factors for survival and tumor c ***:One hundred seventy-two patients with b rain metastases were managed with ra diosurgery *** hundred twent y-one patients were evaluable with follow-up imaging after *** median patien t age was 60.5years(age range,16-86yr).The mean marginal tumor dose and volume were 18.5Gy (range,11-22Gy )and 4.4ml (range,0.1-24.9ml ).Eighty percent of patients had soli tary ***:The overall median survival time *** median survival time in patients with no evidence of primary tumor disease or stable disease was 13and *** local tumor contr ol rate was 87%.At 2years,the rate of local control,remote brain control,and total intr acranial control were 75%,41%,and 27%,*** multivariate a nalysis,advanced primary tumor status(P=0.0003),older age(P=0.008),lower Karnofsky Performance Scale score(P=0.01),and malignant melanoma (P=0.005)were significant for poorer surviva *** median survival time was 28mon ths for patients younger than 60years of age,with Karnofsky Performance Scale score o f at least 90,and whose primary tumor status showed either no evidence of disease or stable *** volume (P=0.02)alone was significant for local tumo r control,whereas no factor affecte d remote or intracranial tumor contr *** patients developed complica tions,six of which were ***(16.5%)of 116patients in whom the cause of death was obtained died as a result of cause s related to brain ***:Brain metastases were controlled

关键词：脑转移瘤局部放射外科治疗全脑放射疗法比较

Anticancer activity of diterpenes and steroids from Eunicella singularis against two- and three-dimensional breast cancer cell models

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Journal of Coastal Life medicine 2017年第12期5卷 531-539页

作者： Sirine Lajili monia deghrigue Amal Abdelhamid Snezana Bjelogrlic Christian D.muller maria Valeria D’auria Abderrahman Bouraoui Laboratoire de Développement Chimique Galénique et Pharmacologique des Médicaments(LR12ES09).Unitéde Pharmacologie MarineFacultéde PharmacieUniversitéde Monastir5000 MonastirTunisia Institut Pluridisciplinaire Hubert Curien UMR 7178 CNRSFacultéde PharmacieUniversitéde Strasbourg74 Route du Rhin67401 IllkirchFrance National Cancer Research Center of Serbia Pasterova 1411000 BelgradeSerbia department of Pharmacy University of Naples“Federico II”via D.Montesano 49I-80131 NapoliItaly.

Objective: To investigate the anticancer activity of two diterpenes [palmonine F (C1) and palmonine D (C2)] and three steroids [cholesta-5,22-dien-3β-ol (C3), stigmasterol (C4) and 5α-cholest-5-en-3β-ol (C5)], isolated from the mediterranean gorgonian Eunicella singularis, against mCF-7 breast cancer cell line. methods: This study was performed on standard monolayer two-dimensional (2D) model to evaluate apoptosis by means of AnnexinV-FITC/PI flow cytometry and on three-dimensional (3D) spheroid model using Celigo imaging cytometer for spheroids size analysis. Results: Results indicated that both diterpenes and steroids exhibited an important apoptotic activity in a concentration-dependent manner with EC50 values of 13, 49, 30, 66 and 65 μg/mL for C1, C2, C3, C4 and C5, respectively. Treatment of mCF-73D cell model with C1–C5 induced growth regression of spheroids in a concentration-dependent manner similar to the clinical anti-breast cancer drug Taxol;over ten days of incubation, growth rates were mpounds at 200 μg/mL. Conclusions: The present study indicates that the two diterpenes C1 and C2 and the three steroids C3, C4 and C5, isolated from Eunicella singularis, might be used as anti-breast cancer candidate drugs for further development.

关键词： Eunicella singularis Diterpenes Steroids Apoptosis 3D tumor spheroid Flow cytometry

Leaf Essential Oil from Three Exotic mytaceae Species Growing in the Botanical Garden of Rio de Janeiro, Brazil

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American Journal of Plant Sciences 2016年第6期7卷 834-840页

作者： Antonio C. Siani marcos J. Nakamura Gabrielle P. das Neves Sérgio da S. monteiro mônica Freiman S. Ramos departamento de Química de Produtos Naturais Instituto de Tecnologia em Fármacos Fundacao Oswaldo Cruz Rio de Janeiro Brazil Fórum Itaboraí de Política Ciência e Cultura na Saúde Fundacao Oswaldo Cruz Palácio Itaboraí Petrópolis Brazil departamento de medicamentos Faculdade de Farmácia Faculdade de Farmácia Universidade Federal do Rio de Janeiro CCS Bloco K Cidade Universitária Rio de Janeiro Brazil

The leaf essential oils of three myrtaceae species: melaleuca leucadendra, Lophostemon confertus and Ugni molinae, non-native to Brazil and growing in the Rio de Janeiro Botanical Garden, were obtained by hydrodistillation and analyzed by GC and GC-mS. Oil yields from fresh leaves were 0.76%, 0.08%, and 0.04%, respectively. Sixty-seven percent of m. leucadendra oil was made up of monoterpenes, wherein 1,8-cineole was largely predominant (49%), followed by α-terpineol (7.6%) and terpinen-4-ol (4.3%). The sesquiterpene profile was characterized by a significant amount of viridiflorol (29%). Oil from L. confertus was 42% monoterpenes;the most predominant constituents being α-pinene (20.8%) and α-thujene (7.1%). Total sesquiterpenes (55.4%) comprised spathulenol (28%), globulol (14%), and aromadendrene derivatives (8.5%) as the main species. U. molinae oil was exclusively composed of sesquiterpenes, with a predominance of β-elemene (44%) followed by β-caryophyllene (7.1%), and bicyclogermacrene (6.7%);guaiol-type alcohols made up 30% of its profile. To the best of our knowledge, this is the first time U. molinae leaf oil composition has been described. The composition of m. leucadendra oil corresponded to a chemotype described for a species growing in Cuba, but was different from that produced by m. leucadendra growing in Egypt, Tunisia, and elsewhere in Brazil. The profile of the L. confertus leaf oil showed high similarity with those described for Australian native specimens, in particular in relation to the relevant presence of α-pinene, aromadendrenes, and the guaiol-type alcohols.

关键词： melaleuca leucadendra Lophostemon confertus Ugni molinae myrtaceae Essential oil