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Vitamin D<sub>3</sub>Receptor Activation Rescued Corticostriatal Neural Activity and Improved motor Function in –D<sub>2</sub>R Tardive Dyskinesia mice model

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Journal of Biomedical Science and Engineering 2015年第8期8卷 520-530页

作者： oluwamolakun O. Bankole Babafemi J. Laoye mujittapha U. Sirjao Azeez O. Ishola Damilola E. Oyeleke Wasiu G. Balogun Amin Abdulbasit Ansa E. Cobham Ibukun D. Akinrinade olalekan m. Ogundele department of Biological Sciences College of Sciences Afe Babalola University Ado-Ekiti Nigeria department of Anatomy College of Medicine and Health Sciences Afe Babalola University Ado-Ekiti Nigeria department of Anatomy College of Health Sciences University of Ilorin Ilorin Nigeria department of Physiology College of Health Sciences University of Ilorin Ilorin Nigeria department of Anatomy College of Medicine University of Calabar Calabar Nigeria Instituto Gulbenkian de Ciencia Oerias Portugal department of Anatomy Bingham University College of Medicine Karu Nigeria

Haloperidol-induced dyskinesia has been linked to a reduction in dopamine activity characterized by the inhibition of dopamine receptive sites on D2-receptor (D2R). As a result of D2R inhibition, calcium-linked neural activity is affected and seen as a decline in mo-tor-cognitive function after prolonged haloperidol use in the treatment of psychotic disorders. In this study, we have elucidated the relationship between haloperidol-induced tardive dyskinesia and the neural activity in motor cortex (m1), basal nucleus (CPu), prefrontal cortex (PFC) and hippocampus (CA1). Also, we explored the role of Vitamin D3 receptor (VD3R) activation as a therapeutic target in improving motor-cognitive functions in dyskinetic mice. Dyskinesia was induced in adult BALB/c mice after 28 days of haloperidol treatment (10 mg/Kg;intraperitoneal). We established the presence of abnormal involuntary movements (AIms) in the haloperidol treated mice (-D2) through assessment of the threshold and amplitude of abnormal involuntary movements (AIms) for the Limbs (Li) and Orolingual (ol) area (Li and ol AIms). As a confirmatory test, the dyskinetic mice (-D2) showed high global AIms score when compared with the VD3RA intervention group (-D2/+VDR) for Li and ol AIms. Furthermore, in the behavioral tests, the dyskinetic mice exhibited a decrease in latency of fall (LOF;Rotarod-P 2/+VDR), 100 mg/Kg for 7 days, CPu-CA1 burst activity was restored leading to a decrease in abnormal movement, and an increase in motor function. Ultimately, we deduced that VD3RA activation reduced the threshold of abnormal movement in haloperidol induced dyskinesia.

关键词： Haloperidol VD3R Dyskinesia D2R Neural Activity Corticostriatal

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获得性局限性面部皮肤松弛症:病例报道和文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 41-41页

作者： Perafán m.F. Franca L.F.S. an Riveros C.J. Bejarano Gavilét al. 张宪旗 Hosp.das Clin. da Faculdade de med. Universidade de S.ao Paulo Ave. Dr E neas de Carvalho Aguiar 255 05403-900 S.ao Paulo SP Brazil

Background. Cutis laxa is an uncommon entity characterized by laxity of the sk in, which hangs in loose folds, producing the appearance of premature aging. It can be subdivided into congenital and acquired. This latter variant is rare and the skin involvement varies from generalized to localized. We report a case of a localized acquired cutis laxa confined to the face, without preceding inflammat ory lesions or systemic compromise. Four similar cases have been reported to dat e. The etiology remains unknown and there is no definitive treatment. methods. A 27-year-old White woman came to our hospital with a wrinkled face, pendulous earlobes and drop eyelids. Changes began 5 years prior, and she appeared much ol der than her age. Results. Histological analysis and ultrastructural examination of skin biopsy revealed reduction and fragmentation of elastic fibers, confirmi ng the diagnosis of cutis laxa. No systemic involvement was diagnosed. The patie nt was submitted to plastic surgery for repair, with satisfactory results to dat e. Conclusions. Acquired localized cutis laxa confined to the face without prece ding inflammatory lesions is extremely rare. The etiology remains unknown. Clini cal features and histopathologic findings confirm the diagnosis. Surgical repair seems to be the only therapeutic choice, but the results are variable and tempo rary.

关键词：面部皮肤松弛症文献回顾面部皱纹弹力纤维眼睑松垂整形外科活检组织学早老症炎症变化特效治疗

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